Patents Assigned to The University of Vermont College of Medicine
  • Methods for predicting psychotropic drugs which elicit weight gain
    Patent number: 8148095
    Abstract: The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine H1 receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: April 3, 2012
    Assignees: The Johns Hopkins University, The University of Vermont College of Medicine
    Inventors: Solomon H. Snyder, Alex Huang, Cory Teuscher, Sangwon Kim