Patents Assigned to The University of Virginia Patent Foundation
  • Publication number: 20120053460
    Abstract: In some illustrative embodiments, an incoming signal from a transducer in an ultrasound imaging beam-former apparatus is applied to an in-phase sample-and-hold and a quadrature sample-and-hold. The quadrature sample-and-hold may be clocked a quarter period behind the in-phase sample-and-hold. The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters. A magnitude calculator receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator receives the in-phase and quadrature digital values, and outputs a phase. An apodizer applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination to a image point in substantial proportion to the difference, and a phase rotator applies a second illumination to the image point in substantial proportion to the phase.
    Type: Application
    Filed: August 16, 2011
    Publication date: March 1, 2012
    Applicant: The University of Virginia Patent Foundation
    Inventors: Travis N. Blalock, William F. Walker, John A. Hossack
  • Patent number: 7442687
    Abstract: The invention provides compounds having the following general formula (I): wherein X, R1, R2, R7 and Z are as described herein.
    Type: Grant
    Filed: August 2, 2005
    Date of Patent: October 28, 2008
    Assignee: The University of Virginia Patent Foundation
    Inventors: Jayson M. Rieger, Joel M. Linden, Timothy L. Macdonald, Gail W. Sullivan, Lauren J. Murphree, Robert Alan Figler, Robert Douglas Thompson
  • Publication number: 20060100516
    Abstract: An improved device and method for collecting data used for ultrasonic imaging. The data is gathered over numerous transmit and echo receive cycles, or iterations and combined into a synthetic acquisition representing a complete echo characteristic acquisition. At each iteration, only a portion, or subset, of the echo characteristic is sampled and stored. During the iterations, the portion of the echo characteristic that is measured and sampled is varied by changing the relative sampling instants. That is, the time offset from the transmission to the respective sampling instant is varied. The sample sets representative of the entire echo characteristic are then compiled from the multiple subsets of the ultrasonic transmissions.
    Type: Application
    Filed: October 5, 2005
    Publication date: May 11, 2006
    Applicant: The University of Virginia Patent Foundation
    Inventors: John Hossack, Travis Blalock, William Walker
  • Publication number: 20040228860
    Abstract: The present invention relates to the treatment, inhibition and prevention of cancer by the administration of anti-C3b(i) antibodies. The invention also relates to the treatment, inhibition and prevention of cancer by the administration of IgM antibodies and/or complement components prior to the administration of anti-C3b(i) antibodies. The present invention further relates to the detection, imaging, diagnosis and monitoring of cancer utilizing C3b(i) specific antibodies.
    Type: Application
    Filed: November 21, 2003
    Publication date: November 18, 2004
    Applicant: The University of Virginia Patent Foundation
    Inventors: Ronald Taylor, Alessandra Nardin, William M. Sutherland, Mitchell H. Sokoloff, Leland Chung
  • Patent number: 6660276
    Abstract: The instant disclosure identifies and synthesizes peptide residues initially isolated from a melanoma cell line. The peptides are capable of reconstituting an epitope recognized by tumor specific CTL. Some of the sequences are homologous with proteins identified as pMEL17, tyrosinase and cofilin. The present invention provides for the treatment of melanoma patients using synthetic peptides that reconstitute epitopes for melanoma specific CTL. In another embodiment the peptides are used as vaccines for imparting immunity. Alternatively, in one embodiment the peptides may be used to bind to antigen presenting cells in a method for providing specific antigenic stimulation of CTL. The instant invention provides CTL cell lines capable of recognizing reconstituted HLA-A2.1 epitopes and their use in methods of adoptive immunotherapy.
    Type: Grant
    Filed: April 29, 1994
    Date of Patent: December 9, 2003
    Assignee: The University of Virginia Patent Foundation
    Inventors: Craig L. Slingluff, Victor M. Engelhard, Donald F. Hunt, Jeffrey Shabanowitz, Andrea L. Cox
  • Patent number: 6617355
    Abstract: Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: September 9, 2003
    Assignees: The University of Virginia Patent Foundation, Duke University, The Medical College of Wisconsin Research Foundation, Inc.
    Inventors: Benjamin Gaston, Jonathan S. Stamler, Owen W. Griffith
  • Patent number: 6596534
    Abstract: A therapeutic agent based on a recombinant adenovirus which employs an osteocalcin promoter for the expression of thymidine kinase can be administered intravascularly to treat metastatic cancer, including osteosarcoma, breast cancer, prostate cancer, ocular melanoma or brain cancer. Systemic administration of this agent provides a preferred route over previous disclosure of local direct administration. The same therapeutic agent can be effectively employed in the treatment of benign conditions, including benign prostatic hypertrophy and arteriosclerosis.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: July 22, 2003
    Assignee: The University of Virginia Patent Foundation
    Inventors: Leland W. K. Chung, Chinghai Kao, Robert A. Sikes, Song-Chu Ko, Jun Cheon
  • Patent number: 6572856
    Abstract: The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also relates to methods of treating and preventing cancer, viral infection, or microbial infection in an animal comprising administering to said animal IgG antibodies, IgM antibodies and/or complement components in combination with antibodies specific for C3b(i). The present invention also relates methods of treating and preventing cancer, viral infection or microbial infection in an animal comprising administrating said animal antibodies that immunospecifically bind to one or more cancer cell antigens, viral antigens or microbial antigens, respectively, in combination with antibodies immunospecific for C3b(i). The present invention further relates to the detection, imaging, diagnosis and monitoring of cancer utilizing C3b(i) specific antibodies.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: June 3, 2003
    Assignee: The University of Virginia Patent Foundation
    Inventors: Ronald Taylor, Alessandra Nardin, William M. Sutherland, Mitchell H. Sokoloff, Leland Chung
  • Patent number: 6558671
    Abstract: Cysteine-depleted CTL epitopes can elicit a stronger or more specific CTL response than the native, cysteine-containing CTL epitope of a disease associated antigen.
    Type: Grant
    Filed: September 20, 1999
    Date of Patent: May 6, 2003
    Assignee: The University of Virginia Patent Foundation
    Inventors: Craig L. Slingluff, Donald F. Hunt, Victor H. Engelhard, David Kittlesen
  • Patent number: 6413967
    Abstract: The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-selective inhibitors, methods for preventing proliferation of electrically non-excitable cells with said VG-selective inhibitors as well as methods of treating autoimmune diseases, preventing graft rejections, preventing apoptosis and treating cancer with the same.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: July 2, 2002
    Assignee: The University of Virginia Patents Foundation
    Inventors: Lloyd S. Gray, Doris M. Haverstick, John J. Densmore, Gabor Szabo
  • Patent number: 6330469
    Abstract: In one aspect of the invention, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: December 11, 2001
    Assignee: The University of Virginia Patent Foundation
    Inventors: M. Pamela Griffin, J. Randall Moorman
  • Patent number: 6216032
    Abstract: In one aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a premature newborn infant. The method comprises: (a) continuously monitoring heart rate variability in the premature newborn infant; and (b) identifying at least one characteristic abnormality in the heart rate variability that is associated with the illness. This method can be use to diagnose illnesses such as, but not limited to, sepsis, necrotizing enterocolitis, pneumonia and meningitis. In another aspect, there is provided a method and apparatus for early detection of subacute, potentially catastrophic infectious illness in a patient.
    Type: Grant
    Filed: March 17, 1999
    Date of Patent: April 10, 2001
    Assignee: The University of Virginia Patent Foundation
    Inventors: M. Pamela Griffin, J. Randall Moorman
  • Patent number: 6192320
    Abstract: An interactive multi-station medical specimen analysis system for simultaneously analyzing a medical specimen at remote locations and accessing, for evaluation, the results of each of the analyses at a central laboratory is disclosed. A central laboratory, interacts with remote computers, through a server to review, evaluate and accept or reject specimen analyses. The server communicates with the plurality of remote computers, laboratory computer and a centralized computer via a network. Analytical instruments which are not equipped to communicate with a computer are connected through computer interface software which interprets the instrument language into the computer program language and the computer program language into the instrument language. The interactive system requests analytical tests, transmits the test results to the server databases and receives and displays data from the server databases.
    Type: Grant
    Filed: March 23, 2000
    Date of Patent: February 20, 2001
    Assignee: The University of Virginia Patent Foundation
    Inventors: Keith S. Margrey, Robin A. Felder, James C. Boyd, J. William Holman, John Savory
  • Patent number: 6180612
    Abstract: Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
    Type: Grant
    Filed: October 27, 1998
    Date of Patent: January 30, 2001
    Assignee: The University of Virginia Patent Foundation
    Inventors: Joel W. Hockensmith, Rohini Muthuswami
  • Patent number: 6159467
    Abstract: A therapeutic agent based on a recombinant adenovirus which employs an osteocalcin promoter for the expression of thymidine kinase can be administered intravascularly to treat metastatic cancer, including osteosarcoma, breast cancer, prostate cancer, ocular melanoma or brain cancer. Systemic administration of this agent provides a preferred route over previous disclosure of local direct administration. The same therapeutic agent can be effectively employed in the treatment of benign conditions, including benign prostatic hypertrophy and arteriosclerosis.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: December 12, 2000
    Assignee: The University of Virginia Patent Foundation
    Inventors: Leland W. K. Chung, Chinghai Kao, Robert A. Sikes, Song-Chu Ko, Jun Cheon
  • Patent number: 6096021
    Abstract: A method for occluding aneurysms or peripheral blood vessels is provided which allows for isovolumetric, isobaric delivery of occluding agents to aneurysms or peripheral blood vessels, wherein the aneurysms or peripheral blood vessels are isolated from the general circulation until the occluding agent has stabilized or until occlusion is effected. In particular, a double balloon method for occluding aneurysms or peripheral blood vessels is disclosed wherein a first balloon is inserted into the aneurysm or peripheral blood vessel to deliver an occluding agent, and a second balloon is placed such that it substantially covers the neck of the aneurysm or peripheral blood vessel to substantially seal the aneurysm or peripheral blood vessel from the general circulation. Additionally, an aneurysm or peripheral blood vessel comprising a double balloon configuration useful for occluding aneurysms or peripheral blood vessels is disclosed.
    Type: Grant
    Filed: March 30, 1999
    Date of Patent: August 1, 2000
    Assignee: The University of Virginia Patent Foundation
    Inventors: Gregory Anthony Helm, David Forest Kallmes, Gerald Robert Hankins
  • Patent number: 6093697
    Abstract: Compounds are disclosed which have the formula (I) ##STR1## wherein R.sub.1 -R.sub.2 are each independently selected from the group consisting of: (a) a hydrogen atom; and (b) a lower alkyl group, straight or branched chain, having 1 to 8 carbon atoms; or R.sub.1 -R.sub.2 and the nitrogen atom to which they are bonded may together form a heterocyclic group; R.sub.3 -R.sub.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: July 25, 2000
    Assignee: The University of Virginia Patent Foundation
    Inventors: Joseph Larner, John Price, Thomas Piccariello, Laura Huang
  • Patent number: 6075057
    Abstract: Optically pure enantiomers of avarol are obtained. The enantiomers of avarol are demonstrated to be highly effective inhibitors of .alpha.-glucosidase and .alpha.-mannosidase. Other enzymes assayed were not inhibited by these optically pure compounds. Inhibition of these two enzymes is useful for a variety of assays and probes, and offers particular utility in the treatment of retroviral infection-associated syndromes, such as AIDS.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: June 13, 2000
    Assignee: The University of Virginia Patent Foundation
    Inventors: Sidney M. Hecht, Edward Locke
  • Patent number: 6034133
    Abstract: Frequent application of a virucidal hand lotion containing malic acid, citric acid, and a C.sub.1-6 alcohol will prevent the hand-to-hand transmission of rhinoviruses and reduce the incidence of the "common cold" caused by rhinoviruses.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: March 7, 2000
    Assignee: The University of Virginia Patents Foundation
    Inventors: J. Owen Hendley, Jack M. Gwaltney, Jr., Deborah F. Thacker
  • Patent number: 6004986
    Abstract: The invention relates to methods for treating cerebral vasospasm induced by hemorrhage or cerebral ischemia, by treating patients with a therapeutically effective amount of a lipophilic iron chelator.
    Type: Grant
    Filed: May 8, 1998
    Date of Patent: December 21, 1999
    Assignee: The University of Virginia Patent Foundation
    Inventors: Adam S. Arthur, Giuseppe Lanzino