Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Type:
Application
Filed:
March 23, 2023
Publication date:
August 24, 2023
Applicant:
University of Washington
Inventors:
Georg Seelig, Richard Muscat, Alexander B. Rosenberg
Abstract: The current disclosure provides use of high dose nicotinamide adenine dinucleotide (NAD) precursor regimens for reduction of inflammation in human patients with preexisting inflammation. The NAD precursor can be nicotinamide riboside (NR) and the high dose regimen can include at least 1000 or 2000 mg/day for at least 9 days.
Type:
Application
Filed:
August 27, 2021
Publication date:
August 24, 2023
Applicant:
University of Washington
Inventors:
Rong Tian, Dennis Ding-Hwa Wang, Bo Zhou, Kevin Douglas O'Brien
Abstract: Devices and methods configured to determine characteristics of tissue specimens are provided. Representative tissue analysis devices include a sensing module and a reference module. The sensing module includes a first post and a second post configured to have the tissue specimen affixed thereto, and a displacement sensor configured to output a displacement signal corresponding to a displacement of the first post. The reference module includes a reference sensor configured to output a reference signal corresponding to a reference input such as an ambient magnetic field. The devices further include instructions that determine: a displacement value based upon the displacement signal; a reference value based upon the reference signal; a reference-canceled displacement value based upon the displacement value and the reference value; and a characteristic of the tissue specimen based upon the reference-canceled displacement value.
Type:
Application
Filed:
October 7, 2020
Publication date:
August 24, 2023
Applicant:
University of Washington
Inventors:
Nathan J. Sniadecki, Ty Higashi, Daniel Moskowitz, Jevne Micheau-Cunningham, Robert Bruce Darling
Abstract: Catheter systems configured for emergency blood-vessel occlusion and associated devices, systems, and methods are disclosed herein. A catheter system configured in accordance with a particular embodiment includes a catheter, a sheath, and an extracorporeal proximity sensor. The catheter includes an elongated body having a tip, a sealing portion, and a main shaft proximal to the sealing portion. The tip is configured to dilate a blood vessel ahead of the distal end portion of the sheath as the catheter and the sheath are advanced together through the blood vessel. The distal end portion of the sheath is configured to fit snugly around the sealing portion. The catheter further includes a balloon and a proximity-sensor target less than about 10 centimeters from the balloon. The proximity sensor is configured to receive a signal from the proximity-sensor target to aid in positioning the balloon without fluoroscopic guidance.
Abstract: Disclosed herein are nanostructures and their use, where the nanostructures include (a) a plurality of first assemblies, each first assembly comprising a plurality of identical first polypeptides; (b) a plurality of second assemblies, each second assembly comprising a plurality of identical second polypeptides, wherein the second polypeptide differs from the first polypeptide; wherein the plurality of first assemblies non-covalently interact with the plurality of second assemblies to form a nanostructures; and wherein the nanostructure displays multiple copies of one or more paramyxovirus and/or pneumovirus F proteins or antigenic fragments thereof, on an exterior of the nanostructure.
Type:
Grant
Filed:
November 10, 2021
Date of Patent:
August 22, 2023
Assignees:
University of Washington, Institute for Research in Biomedicine
Inventors:
Neil P. King, David Baker, Brooke Fiala, Lance Joseph Stewart, Laurent Perez, Antonio Lanzavecchia, Jessica Marcandalli
Abstract: Examples of systems and methods described herein may provide saliency-based video compression. A saliency map associated with a video may be generated and/or provided. A tile configuration may be selected for the video and quality settings assigned to each tile in accordance with the saliency map. The video may then be compressed (e.g., encoded) in tiles in accordance with the quality settings. Compressed videos may be stored together with saliency metadata, facilitating storage management and/or re-compression.
Type:
Grant
Filed:
August 6, 2019
Date of Patent:
August 15, 2023
Assignee:
University of Washington
Inventors:
Amrita Mazumdar, Luis Ceze, Mark H. Oskin
Abstract: Described herein are methods and compositions for reducing or preventing arrhythmias associated with or caused by transplantation of cardiomyocytes to cardiac tissue. In particular embodiments, the pre-treatment of in vitro-differentiated cardiomyocytes with amiodarone before administration to cardiac tissue for engraftment reduces or prevents engraftment arrhythmias, and/or reduces the need for adjunctive anti-arrhythmia drugs after cell administration.
Type:
Application
Filed:
January 20, 2023
Publication date:
August 10, 2023
Applicant:
University of Washington
Inventors:
Charles E. MURRY, William Robb MACLELLAN, Robert Scott THIES, Kenta NAKAMURA
Abstract: A thermally representative phantom mammalian manikin assembly is provided. The assembly can include a cover portion representative of mammalian tissue partially enclosing a thermal cavity having a thermally representative material therein. The cover portion can have an opening with a cap extending across the opening and configured to further enclose the thermal cavity. The cap can have an aperture extending therethrough to receive a device extending through the aperture and into the thermally representative material within the thermal cavity. The device can be a thermocouple configured to measure a temperature of the thermally representative material. In assemblies representing mammalian limbs, the assembly can further include a second thermal cavity representing an additional portion of the limb, e.g., thermally representative upper and lower leg cavities.
Type:
Application
Filed:
February 10, 2023
Publication date:
August 10, 2023
Applicant:
University of Washington
Inventors:
Shahram Aarabi, Jason Germany, Abhijith Shasheendra, Ketan Sunil Mhetre
Abstract: Methods and systems for improved labeling and/or de-labeling a molecule or cell in the context of scientific experimentation, industrial applications, and clinical investigation, including the means to repeat the process of labeling and de-labeling in an efficient manner.
Abstract: The presently disclosed subject matter provides for expression cassettes that allow for expression of a globin gene or a functional portion thereof, vectors comprising thereof, and cells transduced with such expression cassettes and vectors. The presently disclosed subject matter further provides methods for treating a hemoglobinopathy in a subject comprising administering an effective amount of such transduced cells to the subject.
Type:
Grant
Filed:
March 3, 2017
Date of Patent:
August 8, 2023
Assignees:
MEMORIAL SLOAN-KETTERING CANCER CENTER, UNIVERSITY OF WASHINGTON
Inventors:
Michel Sadelain, Isabelle Riviere, Jorge Mansilla-Soto, Xiuyan Wang, George Stamatoyannopoulos, John Stamatoyannopoulos, Mingdong Liu
Abstract: Fracture-induced composite sensors and methods of their fabrication are disclosed. The sensors can be used as strain sensors, piezo-resistive sensors, piezo-capacitive sensors, and non-contact displacement wearable sensors.
Type:
Grant
Filed:
December 3, 2018
Date of Patent:
August 8, 2023
Assignee:
University of Washington
Inventors:
Jae-Hyun Chung, Jinyuan Zhang, Dayong Gao, Jinkyu Yang
Abstract: An adaptive system for efficient and long-range wireless power delivery using magnetically coupled resonators responds to changes in a dynamic environment, and maintains high efficiency over a narrow or fixed frequency range. The system uses adaptive impedance matching to maintain high efficiency. The wireless power transfer system includes a drive inductor coupled to a high-Q transmitter coil, and a load inductor coupled to a high-Q receiver coil. The transmitter coil and receiver coil for a magnetically coupled resonator. A first matching network is (i) operably coupled to the drive inductor and configured to selectively adjust the impedance between the drive inductor and the transmitter coil, or (ii) is operably coupled to the load inductor and configured to selectively adjust the impedance between the load inductor and the receiver coil.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
August 8, 2023
Assignee:
University of Washington through its Center for Commercialization
Inventors:
Joshua R. Smith, Benjamin H. Waters, Scott Wisdom, Alanson P. Sample
Abstract: Examples of digital architectures for OFDM backscatter communication are described herein that use RF switches and discrete loads to implement digitally controlled single-sideband OFDM backscatter devices. One or more transforms may be implemented, including one or more IFFTs, LUTs, and/or numerically-controlled oscillators using one or more sine LUTs.
Type:
Grant
Filed:
January 14, 2022
Date of Patent:
August 8, 2023
Assignee:
University of Washington
Inventors:
James D. Rosenthal, Matthew S. Reynolds
Abstract: Examples of systems and methods described herein may be used to track a tagged object through a scene. Techniques are described herein to calculate a position of the tag using wireless communication with multiple anchor devices. In some examples, the anchor devices may be self-localizing, e.g., they may dynamically determine their position and relationship to one another. In some examples, position of a tag may be calculated by calculating multiple candidate positions using different localization techniques—such as geometric localization techniques and/or optimization-based techniques. An error may also be identified associated with each candidate position. A final position may be determined for the tag based on the errors associated with the candidate positions (e.g., the candidate position with the smallest error may be utilized as the position, e.g., the determined position, of the tag).
Abstract: In some embodiments, a battery management system is provided. The battery management system comprises a connector for electrically coupling a battery to the battery management system, at least one sensor configured to detect a battery state, a programmable chip configured to control at least one of charging and discharging of the battery, and a controller device. The controller device is configured to receive at least one battery state from the at least one sensor; provide the at least one battery state as input to a tanks-in-series model that represents the battery; and provide at least one output of the tanks-in-series model to the programmable chip for controlling at least one of charging and discharging of the battery.
Type:
Grant
Filed:
September 23, 2020
Date of Patent:
July 25, 2023
Assignees:
University of Washington, BattGenie Inc.
Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
Type:
Grant
Filed:
September 23, 2019
Date of Patent:
July 25, 2023
Assignees:
UNIVERSITY OF WASHINGTON, GENEVANT SCIENCES GMBH
Inventors:
Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
Abstract: Methods of uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are provided. Kits for uniquely labeling or barcoding molecules within a cell, a plurality of cells, and/or a tissue are also provided. The molecules to be labeled may include, but are not limited to, RNAs, cDNAs, DNAs, proteins, peptides, and/or antigens.
Type:
Application
Filed:
January 24, 2023
Publication date:
July 20, 2023
Applicant:
University of Washington
Inventors:
Georg Seelig, Richard Muscat, Alexander B. Rosenberg
Abstract: Apparatus and methods for determining a concentration of one or more halogen-containing ions in a sample, including but not limited to: soils, aquifers, groundwater, drinking water, soil, tissue, blood, sewage sludge, compost, and landfill leachate, Particularly, the apparatus and processes are used for the destruction of per- and polyfluoroalkyl substances (PFAS), per- and polyfluorocarbons (PFCs), pesticides, munitions, 1,4-dioxane, pharmaceuticals, microplastics, and others. High destruction efficiencies of these substances is desirable for determination of compliance with government regulations. Apparatus include batch- and continuous-type reactor systems. Processes include supercritical water oxidation (SCWO) and hydrothermal alkaline treatments (HALT).
Abstract: In some embodiments, techniques for using machine learning to enable visible light pupilometry are provided. In some embodiments, a smartphone may be used to create a visible light video recording of a pupillary light reflex (PLR). A machine learning model may be used to detect a size of a pupil in the video recording over time, and the size over time may be presented to a clinician. In some embodiments, a system that includes a smartphone and a box that holds the smartphone in a predetermined relationship to a subject's face is provided. In some embodiments, a sequential convolutional neural network architecture is used. In some embodiments, a fully convolutional neural network architecture is used.
Type:
Application
Filed:
March 20, 2023
Publication date:
July 20, 2023
Applicant:
University of Washington
Inventors:
Lynn B. McGrath, Anthony Law, Randall Bly, Shwetak N. Patel, Alex T. Mariakakis, Jacob Baudin