Patents Assigned to The University of Western Ontario
  • Publication number: 20220195018
    Abstract: A pharmaceutical composition comprising an agent that increases the expression of a purR gene in a bacterium and a method of attenuating, preventing or treating a bacterial infection in a subject comprising administering to the subject an agent that increases the expression of a purR gene.
    Type: Application
    Filed: February 5, 2020
    Publication date: June 23, 2022
    Applicant: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: David E. HEINRICHS, Ronald S. FLANNAGAN
  • Patent number: 11365330
    Abstract: The present disclosure provides a process for the synthesis of bio-based formaldehyde-free wood adhesive with lignin and cellulose derived bio-oil which can be generated from the fractionation/liquefaction of lignocellulose biomass such as agricultural and forestry wastes. Curable groups are introduced onto the bio oil through functionalization reaction with cyclic anhydrides such as maleic anhydride, citric anhydride, phthalic anhydride, succinic anhydride, methyl succinic anhydride. Wood adhesives are formulated with the functionalized bio oil by addition of water and curing agents. Two-ply plywood samples were prepared following the ASTM International Standard 2017, D2339-98 and cured on a hot press between 190-200° C. for 3-4 min under 3 MPa pressure. The plywood samples have dry and wet strengths in the range of up to 3.5 MPa with over 80% wood failure.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: June 21, 2022
    Assignee: The University of Western Ontario
    Inventors: Zhongshun Yuan, Chunbao Xu, Dennise Johanna Sosa Carrero, Hongwei Li
  • Patent number: 11352336
    Abstract: Disclosed is a cost-effective process for catalytic conversion of simple C6-based sugars (such as glucose and fructose) and industrial-grade sugar syrups derived from starch (such as different grades of High Fructose Corn Syrup) and cellulosic biomass to 5-HydroxyMethylFurfural (5-HMF) in a continuous-flow tubular reactor in bi-phasic media using inexpensive heterogeneous solid catalysts. Commercial and synthesized heterogeneous solid catalysts were used and their activities in terms of sugar conversion and HMF selectivity and yield were compared. Continuous dehydration of fructose, glucose and industrial-grade sugar syrups derived from corn and wood to HMF was achieved and the stability of selected catalysts and feasibility of catalyst recycling and regeneration were demonstrated.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: June 7, 2022
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Chunbao Xu, Sadra Souzanchi, Tirumala Venkateswara Rao Kasanneni, Zhongshun Yuan
  • Publication number: 20220056457
    Abstract: A method for modulating a target organism in a microbiome, comprising contacting the microbiome with a cis-conjugative plasmid that can replicate and conjugate with organisms in the microbiome including the target organism, the conjugative plasmid comprising conjugation genes and a gene or a combination of genes capable of being expressed in the target organism and that only modulates the target organism in the microbiome. Also the isolated cis-conjugative plasmid comprising conjugation genes and a gene or a combination of genes capable of being expressed in a target bacteria within a microbiome or biofilm and that modulates the target bacteria in the microbiome or biofilm.
    Type: Application
    Filed: December 11, 2019
    Publication date: February 24, 2022
    Applicant: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: David R. EDGELL, Gregory B. GLOOR, Bogumil J. KARAS
  • Patent number: 11060041
    Abstract: The disclosed invention is a process for liquefaction of hydrolysis residue of lignocellulosic biomass, original lignocellulosic biomass or municipal solid waste in alcohol-water media at alkaline conditions, for the production of low-Mw bio-oils. The disclosed process is characterized in that it works for the direct liquefaction of the biomass, and operates under mild conditions (<300° C. and <10 MPa) employing alkali compounds as catalysts (NaOH, KOH, CaO, Na2CO3, K2CO3, Ca(OH)2 or Ba(OH)2). The process is further characterized in that it employs mixed solvents (glycerol-water, ethylene-glycol, water, glycerol-alcohol-water or ethylene-glycol-alcohol water), where all solvents are recyclable and reusable. The low-Mw bio-oils from hydrolysis residue of lignocellulosic biomass, original lignocellulosic biomass or municipal solid waste can be utilized as a liquid bio-fuel or bio-based chemicals for the production of various bio-based materials.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: July 13, 2021
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Chunbao Xu, Zhongshun Yuan, Shanghuan Feng
  • Patent number: 11047941
    Abstract: A magnetic resonance imaging method comprises performing imaging where more than one polarizing magnetic field strength is used during scanning and processing at least one image resulting from the scanning to yield an enhanced contrast image.
    Type: Grant
    Filed: July 18, 2018
    Date of Patent: June 29, 2021
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Jamu Alford, Blaine Chronik, Brian Rutt
  • Patent number: 10906010
    Abstract: The present disclosure provides a method for producing a water permeable molecular sieve in which a porous substrate having micron-size pores has deposited on a surface thereof non-porous 2D platelets to seal, at the substrate surface, pores in the porous substrate to form a layer of 2D platelets. A curable sealing material is deposited onto the layer of 2D platelets and any remaining exposed areas of the surface of the porous substrate and curing the curable sealing material in order to form a sealed layer on the surface of the porous substrate to prevent water by-passing the non-porous 2D platelets and passing through the porous substrate. An array of sub-nanopores are then produced through the sealed layer with the array of sub-nanopores having a size to allow water to pass therethrough but not metal ions to give a water permeable molecular sieve characterized by water permeability at low di?erential pressures.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: February 2, 2021
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Giovanni Fanchini, Jaewoo Park
  • Patent number: 10806832
    Abstract: Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing the copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettability of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: October 20, 2020
    Assignees: ARLANXEO SWITZERLAND S.A., UNIVERSITY OF WESTERN ONTARIO
    Inventors: Goran Stojcevic, Gilles Arsenault, Elizabeth R. Gillies, Colin V. Bonduelle, Matthew J. McEachran
  • Patent number: 10772218
    Abstract: A one-step react-on-demand (RoD) method for fabricating flexible circuits with ultra-low sheet resistance, enhanced safety and durability. With the special functionalized substrate, a real-time three-dimensional synthesize of silver plates in micro scale was triggered on-demand right beneath the tip in the water-swelled PVA coating, forming a three-dimensional metal-polymer (3DMP) hybrid structure of ˜7 ?m with one single stroke. The as-fabricated silver traces show an enhanced durability and ultralow sheet resistance down to 4 m?/sq which is by far the lowest sheet resistance reported in literatures achieved by direct writing. Meanwhile, PVA seal small particles inside the film, adding additional safety to this technology. Since neither nanomaterials nor a harsh fabrication environment are required, the proposed method remains low-cost, user friendly and accessible to end-users.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: September 8, 2020
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventor: Tengyuan Zhang
  • Patent number: 10689282
    Abstract: This disclosure provides a process based on hydrothermal liquefaction (HTL) treatment for co-processing of high-water-content wastewater sludge and other lignocellulosic biomass for co-production of biogas and bio-crude oil. The mixture of waste activated sludge and lignocellulosic biomass such as birchwood sawdust/cornstalk/MSW was converted under HTL conditions in presence of KOH as the homogeneous catalyst. The operating conditions including reaction temperature, reaction time and solids concentration were optimized based on the response surface methodology for the maximum bio-crude oil production. The highest bio-crude oil yield of around 34 wt % was obtained by co-feeding waste activated sludge with lignocellulosic biomass at an optimum temperature of 310° C., reaction time of 10 min, and solids concentration of 10 wt %. The two by-products from this process (bio-char and water-soluble products) can be used to produce energy as well.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: June 23, 2020
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Chunbao Xu, Laleh Nazari, Madhumita B. Ray
  • Patent number: 10667752
    Abstract: A hand-held catheter force control device includes an elongate base sized to be hand-held. The base defines a longitudinal axis between first and second opposing longitudinal ends. A linear actuator is mounted to the base to provide linear motion substantially parallel to the longitudinal axis of the base. A sheath clamp is coupled to the base. The sheath clamp is sized to fixedly capture a sheath handle. A catheter clamp is coupled to the linear actuator. The catheter clamp is sized to fixedly capture a catheter, and is aligned to be substantially co-axial with the sheath clamp. Systems and methods can incorporate the catheter force control device.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: June 2, 2020
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Daniel Gelman, Allan Skanes, Maria Drangova
  • Patent number: 10663548
    Abstract: A method for contrast agent enhanced magnetic resonance imaging (MRI) of a target sample, comprising generating a magnetic field shift in a polarizing magnetic field during a relaxation portion of an MRI pulse sequence and thereafter acquiring an MR image.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: May 26, 2020
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Jamu Alford, Blaine Chronik, Timothy Scholl
  • Patent number: 10538618
    Abstract: Disclosed herein are redox-active 6-oxoverdazyl polymers having structures (S1) and (S2) synthesized via ring-opening metathesis polymerization (ROMP) and their solution, bulk, and thin-film properties investigated. Detailed studies of the ROMP method employed confirmed that stable radical polymers with controlled molecular weights and narrow molecular weight distributions (Ð<1.2) were produced. Thermal gravimetric analysis of a representative example of the title polymers demonstrated stability up to 190° C., while differential scanning calorimetry studies revealed a glass transition temperature of 152° C. An ultrathin memristor device was produced using these polymers, namely a 10 nm homogeneous thin film of poly-[1,5-diisopropyl-3-(cis-5-norbornene-exo-2,3-dicarboxiimide)-6-oxoverdazyl] (P6OV), a poly-radical with three tunable charge states per each radical monomer: positive, neutral and negative.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: January 21, 2020
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Joe B. Gilroy, Giovanni Fanchini, Joseph A. Paquette, Sabastine C. Ezugwu
  • Patent number: 10472448
    Abstract: Three dimensional printed objects having surface coatings, such as a hydrophobic coating or metalized surface, 3D printed substrates having an outer surface that can be tuned by application of such a coating, and methods for the fabrication of such objects and substrates are described. A surface initiator is incorporated into the 3D substrate during layer-by-layer printing, and the surface coated by surface-initiated atom transfer radical polymerization (SI-ATRP).
    Type: Grant
    Filed: August 8, 2014
    Date of Patent: November 12, 2019
    Assignee: The University of Western Ontario
    Inventors: Jun Yang, Xiaolong Wang, Xiaobing Cai, Qiuquan Guo
  • Publication number: 20190307638
    Abstract: An oral device includes an intraoral bolus simulator comprising an exterior surface and having an interior volume Tillable with a fluid. An extraoral user interface extends from the bolus simulator, and can be used to locate or position the intraoral bolus simulator. In various embodiments, the fluid may be a gas or a liquid, or combinations thereof. In other embodiments, an oral device includes an extraoral handle, a shield connected to the handle, a tether extending from the shield, and a bolus simulator connected to the tether.
    Type: Application
    Filed: December 12, 2017
    Publication date: October 10, 2019
    Applicants: Trudell Medical International, The University of Western Ontario
    Inventors: Ruth E. Martin, Marcus Sieffert, Peter Scarrott, Andreas Rifani, Kelly Armstrong
  • Patent number: 10413690
    Abstract: The present invention relates generally to an oral device, or mouthpiece, for delivering a fluid to the mouth or oropharynx of a user. In one embodiment, the oral device includes an intraoral portion, an extraoral portion, and an auxiliary support device that serves to stabilize the oral device. In various embodiments, the auxiliary support device may be configured with ear loops, a support band, a support frame and/or a support member. The intraoral portion generally includes at least one outlet port through which the fluid is delivered to the oral cavity or oropharynx. A method of dispensing a fluid using the oral device is also provided.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: September 17, 2019
    Assignees: The University of Western Ontario, Trudell Medical International
    Inventors: Ruth E. Martin, Michael Nuttall, Bryan Finlay, Julie Theurer, Brandon Coultes
  • Patent number: 10400944
    Abstract: Disclosed is a counterbalance system for moving a payload and a method for counterbalancing the payload. The system and method comprise a resilient member that is in communication with the payload to be moved and two resilient members that are in communication with either end of the first resilient member. An actuator is in communication with the first and third resilient members and a payload arm, attached to the payload, is in communication with the first and second resilient members. The resilient members may be compressed and relaxed during movement of the actuator and the payload arm so that energy may be transferred between the system and the payload to counterbalance the weight of the payload.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: September 3, 2019
    Assignees: Centre for Imaging Technology Commercialization, The University of Western Ontario
    Inventors: Jeffrey Bax, Christopher Waring, Aaron Fenster
  • Patent number: 10322215
    Abstract: Functionalized copolymers of isoolefins and conjugated diolefins, methods of preparing the copolymers, and their use as compatibilizers are disclosed. The diolefin monomer units of the co-polymer are modified at the C—C double bond along the backbone of the copolymer to include an oxygen containing functional group such as epoxide, ester or alcohol. The functionalized copolymers improve the wettability of a non-hydrophilic surface towards hydrophilic polymer and allows for the formation of homogenous layers of the hydrophilic polymers. In particular, the spreading of a hydrophilic polymer on a non-hydrophilic substrate is facilitated by applying the co-polymers as an interfacial layer between the two incompatible materials. The resulting coated substrates exhibit resistance to protein adsorption and cell growth after grafting. The co-polymers are especially suited in the coating of biomedical devices where a high degree of uniformity of the coated surface is required.
    Type: Grant
    Filed: August 11, 2011
    Date of Patent: June 18, 2019
    Assignees: LANXESS INTERNATIONAL SA, UNIVERSITY OF WESTERN ONTARIO
    Inventors: Goran Stojcevic, Gilles Arsenault, Elizabeth R. Gillies, Collin V. Bonduelle, Matthew J. McEachran
  • Patent number: 10274499
    Abstract: The present invention relates to variant SH2 domains for binding a phosphotyrosine (pTyr)-containing peptide. The variant SH2 domains of the present invention include a parent SH2 domain having at least one amino acid substitution in a pre-defined region of 15 amino acid positions of the parent SR2 domain, wherein said at least one amino acid substitution increases the affinity of the variant SH2 domain for the pTyr-containing peptide relative to the parent SH2 domain. The present application relates also to methods of using the variant SH2 domains in the treatment of protein kinase-associated disorders, or the diagnosis or prognosis of protein kinase-associated disorders, for isolating and measuring the concentration of pTyr-containing molecules, and as reagents in research.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: April 30, 2019
    Assignees: THE UNIVERSITY OF WESTERN ONTARIO, THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
    Inventors: Shun-Cheng Li, Tomonori Kaneko, Xuan Cao, Sachdev Singh Sidhu, Haiming Huang
  • Patent number: 10266633
    Abstract: A resin composition containing the reaction product of a 5-hydroxymethyl furfural (HMF) produced in-situ from e.g., glucose and a phenolic compound. Phenolic compounds include phenol, cardanol and bio-phenol. The resin is heat-curable using cross-linking agents such as tetraethylammonium chloride or lignin, etc.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: April 23, 2019
    Assignee: THE UNIVERSITY OF WESTERN ONTARIO
    Inventors: Chunbao Xu, Yongsheng Zhang, Zhongshun Yuan