Abstract: The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.

Abstract: An equine training aid for enabling a horse, pony, donkey or the like, particularly dressage or show horses, to adopt an optimum outline or profile. The training aid includes a self-centering, continuous loop portion (1), configured, during lunging or riding, to be in contact tension with the equine wherein the continuous loop portion (1) includes a front section (1a) and a rear section (1b) each of which are linked by a linker such as the form of rings (2a) and pivotal clips (2b). Each of the loop sections (1a) and (1b) additionally has two adjustment mechanisms (e.g. sliders; (3)) to allow each loop section to be lengthened or shortened and both ends of the rear section (1b) terminate in a safety loop (4) which allows rotation of the device to a limited extent and prevents the rear section of the loop portion (1b) from slipping down the hind legs of the equine when the device is being dismantled and removed from the equine.