Patents Assigned to The University of Zurich
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Patent number: 11971416Abstract: An analysis apparatus (1) includes a housing unit (10) that houses a biological sample (S), a staining dispenser unit (20) that fluorescently stains the biological sample (S), an image acquisition unit (30) that acquires an image of the biological sample (S), a washer unit (40) that destains the biological sample (S), a drive unit (50), and a control unit (90) that analyzes the image and controls the drive unit (50). The control unit (90) performs adjustments so that the staining dispenser unit (20) and the housing unit (10) satisfy a first position condition, performs adjustments so that the image acquisition unit (30) and the housing unit (10) satisfy a second position condition, and performs adjustments so that the washer unit (40) and the housing unit (10) satisfy a third position condition. The analysis apparatus (1) maximizes the actual photography range of information related to the biological sample.Type: GrantFiled: June 9, 2021Date of Patent: April 30, 2024Assignees: YOKOGAWA ELECTRIC CORPORATION, University of ZurichInventors: Takayuki Kei, Yohei Tsubouchi, Lucas Pelkmans, Gabriele Gut
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Publication number: 20230302050Abstract: The present application relates to fully humanized anti-FGFR4 single domain antibodies (sdAbs) and variants thereof. The present invention further relates to functionalized drug nanocarriers, nucleic acids, vectors, host cells, immune cells comprising said sdAbs, and compositions comprising thereof, as well as their use for therapy.Type: ApplicationFiled: May 20, 2021Publication date: September 28, 2023Applicants: Institut Curie, Centre National de la Recherche Scientifique, The University of Zurich, Honing BiosciencesInventors: Sandrine Moutel, Franck Perez, Michele Bernasconi, Nagjie Laila Alijaj, Zélia Gouveia
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Publication number: 20230287106Abstract: Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced ?-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).Type: ApplicationFiled: November 9, 2022Publication date: September 14, 2023Applicants: Neurimmune Holding AG, University of ZurichInventors: Jan GRIMM, Fabrice HEITZ, Fabian WIRTH, Tobias WELT
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Publication number: 20230255156Abstract: The present invention relates to maize plants having increased pathogen resistance or tolerance, in particular increased resistance or tolerance to pathogens causing Northern Corn Leaf Blight, i.e. Exserohilum turcicum. Such maize plants are characterized by particular molecular markers The invention further relates to methods for identifying such maize plants.Type: ApplicationFiled: July 14, 2021Publication date: August 17, 2023Applicants: KWS SAAT SE & Co. KGaA, UNIVERSITY OF ZURICHInventors: Daniela SCHEUERMANN, Milena OUZUNOVA, Bettina KESSEL, Beat KELLER, Ping YANG
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Publication number: 20230242643Abstract: Chimeric antigen receptor (CAR) bridging protein are provided comprising a CAR-binding domain linked to an antigen-binding domain, which can be used to re-direct the targeting of CAR-T cells. The bridging protein may comprie an antigen-binding domain that targets any antigen of interest, such as, for example, a tumor antigen or viral antigen. Also provided are methods of using the bridging proteins in combination with CAR-T cells to treat a disease, such as, for example, a cancer or an infectious disease.Type: ApplicationFiled: May 27, 2021Publication date: August 3, 2023Applicants: ANTION BIOSCIENCES SA, GENEVA UNIVERSITY HOSPITALS, UNIVERSITY OF GENEVA, UNIVERSITY OF ZURICHInventors: Marco ALESSANDRINI, Karl-Heinz KRAUSE, Renier MYBURGH
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Patent number: 11713351Abstract: The present invention relates to methods for preventing or treating head and neck squamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to; (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using Vb4-845, which is a recombinant immunotoxin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.Type: GrantFiled: October 21, 2020Date of Patent: August 1, 2023Assignee: University of ZürichInventors: Uwe Zangemeister-Wittke, Claudio Di Paolo, Dominique Christine Tschudi, Nicholas Ronald Glover, Dimitri Peter Fitsialos
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Patent number: 11713352Abstract: The present invention relates to methods for preventing or treating head and neck spuamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to; (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using Vb4-845, which is a recombinant immunotoxin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.Type: GrantFiled: April 8, 2021Date of Patent: August 1, 2023Assignee: University of ZürichInventors: Uwe Zangemeister-Wittke, Claudio Di Paolo, Dominique Christine Tschudi, Nicholas Ronald Glover, Dimitri Peter Fitsialos
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Patent number: 11649455Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: GrantFiled: April 1, 2019Date of Patent: May 16, 2023Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
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Patent number: 11613747Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: GrantFiled: April 1, 2019Date of Patent: March 28, 2023Assignees: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz Krause, Francis Rousset, Patrick Salmon, Marco Alessandrini, Roberto Speck, Simon Bredl, Tafadzwa Mlambo, Renier Myburgh
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Patent number: 11608372Abstract: Provided are novel human-derived antibodies specifically recognizing polyomavirus polypeptides, preferably capable of binding to polyomaviruses of the type of JC virus (JCV) and/or BK virus (BKV) as well as methods related thereto. Furthermore, assays and kits related to antibodies specific for polyomaviruses, polyomavirus VP1 and or polyomavirus VP1 Virus-Like Particles (VLPs), preferably of the type of JCV and/or BKV, are disclosed. The human-derived antibodies as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for polyomavirus targeted immunotherapy and diagnostics.Type: GrantFiled: September 11, 2019Date of Patent: March 21, 2023Assignees: Neurimmune Holding AG, University of ZurichInventors: Jan Grimm, Roland Martin, Benoit Combaluzier, Ivan Jelcic
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Publication number: 20230070984Abstract: The present invention relates to compositions comprising gases, particularly oxygen (O2) in an amount of from about 91% to about 99% by volume, and carbon dioxide (CO2) in an amount of from about 1% to about 9% by volume, based upon the total volume of the composition, and their use in mitigating the negative effects of surgery and/or anaesthesia on a patient.Type: ApplicationFiled: February 18, 2021Publication date: March 9, 2023Applicants: AVIATION WORKS LIMITED, UNIVERSITY OF ZURICHInventors: Marc STUDER, Simisola OKE, Rob BOYLE, Beatrice Beck SCHIMMER, Martin SCHLÄPFER
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Publication number: 20230021982Abstract: The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided.Type: ApplicationFiled: August 25, 2022Publication date: January 26, 2023Applicants: KWS SAAT SE & Co. KGaA, UNIVERSITY OF ZURICH, UNIVERSITY OF BERNInventors: Bettina KESSEL, Milena OUZUNOVA, Daniela SCHEUERMANN, Beat KELLER, Simon KRATTINGER, Coraline PRAZ, Ping YANG, Matthias ERB
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Publication number: 20220261649Abstract: Disclosed is a neural network-based inference method and apparatus. The neural network-based inference method includes compressing a matrix comprising processing elements corresponding to an operation of a neural network, balancing workloads related to the operation by reordering the compressed matrix based on the workloads, and performing inference based on the reordered matrix.Type: ApplicationFiled: June 9, 2021Publication date: August 18, 2022Applicants: Samsung Electronics Co., Ltd., University of ZurichInventors: Chang GAO, Shih-Chii LIU, Tobi DELBRUCK, Xi CHEN
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Patent number: 11352441Abstract: Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.Type: GrantFiled: May 28, 2019Date of Patent: June 7, 2022Assignees: NEURIMMUNE HOLDING AG, UNIVERSITY OF ZURICHInventors: Fabio Montrasio, Maria Grazia Barenco Montrasio, Jan Grimm, Roger Nitsch, Christoph Hock, Tobias Welt, Jordan Mcafoose, Marcel Maier
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Publication number: 20210382062Abstract: An analysis apparatus (1) includes a housing unit (10) that houses a biological sample (S), a staining dispenser unit (20) that fluorescently stains the biological sample (S), an image acquisition unit (30) that acquires an image of the biological sample (S), a washer unit (40) that destains the biological sample (S), a drive unit (50), and a control unit (90) that analyzes the image and controls the drive unit (50). The control unit (90) performs adjustments so that the staining dispenser unit (20) and the housing unit (10) satisfy a first position condition, performs adjustments so that the image acquisition unit (30) and the housing unit (10) satisfy a second position condition, and performs adjustments so that the washer unit (40) and the housing unit (10) satisfy a third position condition. The analysis apparatus (1) maximizes the actual photography range of information related to the biological sample.Type: ApplicationFiled: June 9, 2021Publication date: December 9, 2021Applicants: YOKOGAWA ELECTRIC CORPORATION, University of ZurichInventors: Takayuki KEI, Yohei TSUBOUCHI, Lucas PELKMANS, Gabriele GUT
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Publication number: 20210317203Abstract: The present invention relates to methods for preventing or treating head and neck spuamous cell cancer and bladder cancer using an immunotoxin comprising (a) a ligand that binds to a protein on the cancer cell attached to; (b) a toxin that is cytotoxic to the cancer cell. In a specific embodiment, the invention is directed to the prevention or treatment of head and neck squamous cell cancer or bladder cancer using Vb4-845, which is a recombinant immunotoxin comprising a humanized, MOC31-derived, single-chain antibody fragment that is fused to a truncated form of Pseudomonas exotoxin A. Also encompassed by the invention are combination therapy methods, including the use of reduced dosages of chemotherapeutic agents, for the prevention or treatment of cancer. Also encompassed by the invention are formulations and methods for direct administration of the recombinant immunotoxin to the carcinoma, for the prevention or treatment of cancer.Type: ApplicationFiled: April 8, 2021Publication date: October 14, 2021Applicant: University of ZurichInventors: Uwe ZANGEMEISTER-WITTKE, Claudio DI PAOLO, Dominique Christine TSCHUDI, Nicholas Ronald GLOVER, Dimitri Peter FITSIALOS
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Patent number: 11091540Abstract: Provided are TAR DNA-binding protein of 43 kDa (TDP-43)-specific binding molecules including polypeptides such as human antibodies, as well as fragments, derivatives and variants thereof. Also provided are methods related to these TDP-43 specific binding molecules. Assays, kits, and solid supports related to TDP-43-specific binding molecules, including polypeptides such as, human antibodies are also disclosed. The TDP-43-specific binding molecule, antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for TDP-43 targeted immunotherapy and diagnosis, respectively.Type: GrantFiled: February 25, 2019Date of Patent: August 17, 2021Assignees: Biogen International Neuroscience GmbH, University of ZürichInventors: Roger Nitsch, Christoph Hock, Maria Grazia Barenco Montrasio, Fabio Montrasio, Jan Grimm, Jean-Luc Baeriswyl, Paul Weinreb, Janaky Coomaraswamy, Omar Quintero-Monzon
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Publication number: 20210238265Abstract: Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for tau are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for tau targeted immunotherapy and diagnosis, respectively.Type: ApplicationFiled: September 17, 2020Publication date: August 5, 2021Applicants: Biogen International Neuroscience GmbH, University of ZürichInventors: Roger Nitsch, Feng Chen, Jan Grimm, Jean-Luc Baeriswyl, Christoph Hock
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Publication number: 20210095278Abstract: The present disclosure relates to miRNA expression constructs, such as for expression of multiple miRNAs and use thereof to knockdown target gene expression. In some aspects, the expression constructs include a promoter element, a spacer sequence and a miRNA coding sequence. In some aspects, constructs provide enhanced immune cell function.Type: ApplicationFiled: April 1, 2019Publication date: April 1, 2021Applicants: UNIVERSITY OF GENEVA, LES HÔPITAUX UNIVERSITAIRES DE GENÈVE, UNIVERSITY OF ZURICHInventors: Karl-Heinz KRAUSE, Francis ROUSSET, Patrick SALMON, Marco ALESSANDRINI, Roberto SPECK, Simon BREDL, Tafadzwa MLAMBO, Renier MYBURGH
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Publication number: 20210071194Abstract: The present invention relates to a nucleic acid molecule encoding a polypeptide conferring resistance to a plant against a fungal pathogen, such as Helminthosporium turcicum. The present invention further relates to a plant (or part thereof) comprising the nucleic acid molecule, and methods involving the nucleic acid molecule.Type: ApplicationFiled: August 22, 2018Publication date: March 11, 2021Applicants: KWS SAAT SE & Co. KGaA, University of ZurichInventors: Bettina KESSEL, Milena OUZUNOVA, Thomas PRESTERL, Daniela SCHEUERMANN, Gerhard HERREN, Beat KELLER, Simon KRATTINGER, Thomas WICKER, Ping YANG