Abstract: An alloy includes a mixture of aluminum, tin and magnesium. An amount of the magnesium is between about 2.5% and 6.5% by weight of the mixture. The alloy is binder jet printed and liquid phase sintered.

Abstract: An apparatus to directly detect solids formation in a fluid under known pressure and temperature conditions is disclosed. The apparatus includes a vessel having an electromagnetic resonant cavity defined by an upper portion, a lower portion and a gap defined therebetween, the gap having resonant properties sensitive to the presence of a solid phase therein. The upper portion or the lower portion may be provided with a passage extending therethrough in fluid communication with an inlet to allow ingress of a stream of fluid to the gap and thereby purge solids from the cavity subsequent to solids formation. The apparatus also includes one or more probes, one or more sensors and a signal processor operatively connected to said sensors and said one or more probes to directly detect solids formation in the fluid within the cavity in response to detected changes in the resonant properties of the cavity.

Abstract: A brush arrangement of an apparatus includes a brush connected to a brush support. The brush support can be or include at least one four-bar linkage, trails the outlets of the seed metering device. The brush sweeps fine loose material over seeds placed on the soil surface allowing rocks to be left in place in/on the soil while the deposited seeds are lightly covered with soil by the brush. The brush arrangement can be coupled with soil manipulation apparatus, e.g., including a tool/tine support, onto which one or more soil engaging tools mount(s). The soil engaging tool may include or be at least one knifepoint, sweep, disc, blade, or other tillage equipment to engage into the soil and loosen compacted or crusted soil ahead of depositing the seeds. Brush breakout can be accommodated by a breakout coupler and optional adjustable breakout force.

Abstract: The present invention relates to the field of compositions and methods for the treatment of cancer. In particular, the invention relates to novel melittin fusion peptides including an RGD-motif containing peptide that binds to the integrins ?v?6 and ?v?3. Preferably the RGD-motif containing fusion peptide can reduce viability of cancer cells, including in particular, TNBC and HER2-enriched breast cancer cells, and ovarian cancer cells.

Abstract: The present disclosure provides a method of analyzing an area of interest of a sample material which comprises directing a first radiation to a first area of interest, the first radiation having frequencies within a terahertz frequency range. The method also comprises receiving a first signal THz1 being a quantity related to radiation received from the first area of interest in response to directing the first radiation to the first area of interest, the first signal THz1 being dependent on a first property and on a second property of the first area of interest. Further, the method comprises directing a second radiation to the first area of interest, the second radiation having frequencies within a frequency range that is different to that of the first radiation.

Abstract: A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.

Abstract: A method of screening candidate agents for their ability to modulate RAGE activity where such RAGE activity is induced by an active co-located GPCR, the method comprising the steps of: contacting a RAGE polypeptide with a GPCR polypeptide in the presence of a candidate agent where the GPCR polypeptide is constitutively active and/or is activated by addition of an agonist, partial agonist or allosteric modulator of that GPCR; and detecting whether the candidate agent is a modulator of RAGE ligand-independent activation of RAGE by activated co-located GPCR by detecting an effect indicative of modulation of RAGE activation by the presence of the candidate agent and/or by detecting RAGE-dependent signalling that is modulated by the presence of the candidate agent.

Abstract: An apparatus and a process to recover high purity helium from a low helium content feed stream are disclosed. The apparatus includes a first dual reflux pressure swing adsorption (DRPSA) unit and a second DRPSA unit, each unit comprising a high pressure adsorption column and a low pressure adsorption column configured in fluid communication with the high pressure adsorption column. The first DRPSA unit is arranged to receive and separate the feed stream into a first reflux product and a first heavy product and circulate the first reflux product and the first heavy product between the high and low pressure adsorption columns to produce an intermediate helium-enriched stream.

Abstract: A method of impedance flow cytometry comprises: flowing a fluid along a flow channel; applying electrical signals to current paths through the fluid, the current paths comprising at least first and second current paths, and further first and second current paths, wherein the electrical signals applied to the first and further first current paths have a frequency, magnitude and phase, and the electrical signals applied to the second and further second current paths have substantially equal frequency and magnitude and opposite phase to the electrical signals applied to the first and first further current path; detecting current flow in the current paths; producing a first summed signal representing the sum of the current flows detected in the current paths, and a second summed signal representing the sum of the current flows detected in the further current paths; and obtaining a differential signal representing the difference between the summed signals.

Abstract: The present disclosure relates generally to methods and protocols for the diagnosis, prognosis and stratification of patients with, or at risk of developing, sporadic amyotrophic lateral sclerosis (ALS). In particular, the methods and protocols of the present disclosure are based on determination of the presence and number of cytosine (C) adenine (A) dinucleotide repeats (CA dinucleotides) within the STMN2 gene.

Abstract: The invention relates in general to hydrophilic, biocompatible dendronised polymers, to complexes comprising the dendronised polymers, to methods of preparing the dendronised polymer and to uses of the dendronised polymer as a non-viral transfection agent for the delivery of biomolecules, in particular, genome editing tools, into a cell.

Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.

Abstract: A multiphase flow metering device may have a conduit through which a multiphase fluid can flow and a structured packing insert positioned in the conduit. The structured packing insert may have a water-wet packing structure zone and/or an oil-wet packing structure zone. The multiphase flow metering device may also have a Halbach pre-polarizing magnet array positioned around the conduit, an RF coil, an electromagnet, an NMR console adapted to detect NMR signals from the multiphase fluid, and a control system configured to vary a polarization of the Halbach pre-polarizing magnet array. The Halbach pre-polarizing magnet array may be positioned or positionable over one or both of the oil-wet and water-wet packing structure zones. In some embodiments, the structured packing insert may include immobilized radicals, providing for dynamic nuclear polarization of the multiphase fluid.

Abstract: A multiphase flow metering device may have a conduit through which a multiphase fluid can flow and a structured packing insert positioned in the conduit. The structured packing insert may have a water-wet packing structure zone and/or an oil-wet packing structure zone. The multiphase flow metering device may also have a Halbach pre-polarizing magnet array positioned around the conduit, an RF coil, an electromagnet, an NMR console adapted to detect NMR signals from the multiphase fluid, and a control system configured to vary a polarization of the Halbach pre-polarizing magnet array. The Halbach pre-polarizing magnet array may be positioned or positionable over one or both of the oil-wet and water-wet packing structure zones. In some embodiments, the structured packing insert may include immobilized radicals, providing for dynamic nuclear polarization of the multiphase fluid.

Abstract: An isolated or purified antisense oligomer for modifying RNA cleavage and processing in the NEAT1 gene transcript or part thereof.

Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 59.

Abstract: An apparatus to directly detect solids formation in a fluid under known pressure and temperature conditions is disclosed. The apparatus includes a vessel having an electromagnetic resonant cavity defined by an upper portion, a lower portion and a gap defined therebetween, the gap having resonant properties sensitive to the presence of a solid phase therein. The upper portion or the lower portion may be provided with a passage extending therethrough in fluid communication with an inlet to allow ingress of a stream of fluid to the gap and thereby purge solids from the cavity subsequent to solids formation. The apparatus also includes one or more probes, one or more sensors and a signal processor operatively connected to said sensors and said one or more probes to directly detect solids formation in the fluid within the cavity in response to detected changes in the resonant properties of the cavity.

Abstract: This invention relates to a chocolate or chocolate substitute composition or product comprising (a) at least compound to be delivered to a subject; (b) a chocolate or chocolate substitute matrix and at least (i) a masking agent or (ii) a firming agent, wherein the composition or product is substantially stable.

Abstract: Provided herein are biomolecule conjugates, and methods of use thereof, wherein the conjugate comprises a cytokine, typically an immunopotentiating cytokine, and a peptide comprising or consisting of the sequence CSGRRSSKC (SEQ ID NO:1). Biomolecule conjugates of the invention find application, inter alia, in the treatment of tumours, atherosclerosis and fibrosis, and the degradation of ECM associated therewith. Also provided herein are uses of a peptide comprising or consisting of the sequence of SEQ ID NO:1, optionally linked to a detectable agent and/or a carrier, in the detection and/or localisation of tumour, atherosclerotic and fibrotic tissue.

Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.