Abstract: Provided is a drug useful for photoimmunotherapy. Specifically, provided is a conjugate including an antibody molecule, a particle having an average particle diameter of 100 nm or less, and a photosensitive portion. In the conjugate, the particle having an average particle diameter of 100 nm or less is linked to the antibody molecule, and at least one of the antibody molecule or the particle is bound to the photosensitive portion. The photosensitive portion is a portion showing increase of hydrophobicity when irradiated with a light beam having a wavelength of from 500 nm to 900 nm or a portion containing a phthalocyanine skeleton.

Abstract: An iridium/iridium oxide electrode for quantitatively detecting pH in a sulfide ion environment, and a preparation method and use thereof are provided. In the present disclosure, a sensitive layer of the iridium/iridium oxide electrode is coated with a sulfonated polyether ether ketone/ionic liquid (SPEEK/IL) sandwich structure. The SPEEK/IL sandwich structure includes two layers of SPEEK/SiOx/IL composite film and one layer of SPEEK film. The SPEEK film is arranged on an outermost layer. The SPEEK/IL sandwich structure covered on a surface of the electrode has an isolation effect on ions other than hydrogen ions, and especially shows a desirable isolation effect on sulfide ions with a smaller ion size. In this way, the electrode is not easily disturbed by redox substances in a complex aqueous environment.

Abstract: Biomineralization—the synthesis of inorganic materials using proteins—has recently gained interest as a low cost, green route for the production of metal chalcogenide semiconductor nanocrystals. Typical biomineralization approaches rely on proteins or biomolecules identified from organisms which possess a native biomineralization response. Disclosed herein is an alternative biomineralization approach for synthesizing metal chalcogenide nanocrystals which uses an artificially designed de novo protein. De novo proteins are non-natural proteins, allowing for facile modification of the protein through the tuning of amino acids within the sequence. This de novo protein was employed to produce size-controlled populations of semiconductor nanocrystals, with properties consistent with those produced using traditional routes.

Abstract: A classifying sensing system, a classifying method performed using a sensing system, a tactile sensor, and a method of fabricating a tactile sensor. The classifying sensing system comprises a first spiking neural network, SNN, encoder configured for encoding an event-based output of a vision sensor into individual vision modality spiking representations with a first output size; a second SNN encoder configured for encoding an event-based output of a tactile sensor into individual tactile modality spiking representations with a second output size; a combination layer configured for merging the vision modality spiking representations and the tactile modality spiking representations; and a task SNN configured to receive the merged vision modality spiking representations and tactile modality spiking representations and output vision-tactile modality spiking representations with a third output size for classification.

Abstract: A transformable wheel module is disclosed. The transformable wheel module comprises: a plurality of lobes; and a mode switching unit for switching modes between a first traveling mode in which the lobes are coupled in a ring shape and a second traveling mode in which the lobes are separated from each other, wherein the mode switching unit can include: a first rotary link; a second rotary link positioned on the same rotational axis as the first rotary link; a plurality of first connecting links for individually connecting the first rotary link and the lobes; a plurality of second connecting links for individually connecting the second rotary link and the lobes; a first driving motor for rotating the first rotary link; and a second driving motor for rotating the second rotary link.

Abstract: A device is provided. The device includes a memory cell and a first write assist circuit. The memory cell operates with a first supply voltage and a second supply voltage different from the first supply voltage. The first write assist circuit includes a first write assist switch and a second write assist switch that are coupled to the memory cell through a first data line. In a write operation of a data, having a first logic value, to the memory cell, the first write assist switch transmits the first supply voltage to the first data line in response to a first control signal, received at a control terminal of the first write assist switch and having a voltage level of the second supply voltage, when the second write assist switch is configured to be turned off.

Abstract: A material-based subdomain hybrid cellular automata algorithm for solving material optimization of thin-walled frame structures includes an outer loop and an inner loop. The outer loop is to define and update the target cost for the inner loop, and the inner loop is to adjust material using a PID control strategy according to the nominal flow stress of a current cell and the nominal flow stress of candidate materials, so that a current cost of the inner loop converges to the target cost. The material-based subdomain hybrid cellular automata algorithm can effectively solve a nonlinear dynamic response optimization problem in the discrete design space.

Abstract: A use of a detection reagent for a microRNA (miRNA) marker miR-143-3p in the preparation of a product for evaluating a therapeutic effect of olanzapine in the treatment of schizophrenia (SZ) and a kit are provided. An expression level of miR-143-3p can be detected to determine a therapeutic effect of olanzapine in the treatment of SZ of a patient, and can be used as a detection or treatment index in clinical practice, which provides a theoretical basis for the mechanism research of SZ and the clinical application.

Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.

Abstract: A process for making a layered multi-material structural element having controlled mechanical failure characteristics. The process includes the steps of: supplying a cementitious layer and forming a polymer layer on the cementitious layer by additive manufacture such that the polymer layer has a first thickness and the cementitious layer has a second thickness, wherein the polymer layer comprises a polymer and the cementitious layer comprises a cementitious material; and allowing the polymer from the polymer layer to suffuse into the cementitious layer for a period of time to obtain a suffused zone in the cementitious layer such that the suffused zone has a third thickness that is less than half the second thickness.

Abstract: Disclosed are organelles-specific two-photon fluorescent probes, and more particularly, a blue emission two-photon fluorescent probe capable of selectively detecting calcium ions (Ca2+) through fluorescence signals by targeting the cytoplasm, mitochondria, and plasma membrane even among the organelles, respectively, and a green emission two-photon fluorescent probe capable of selectively detecting hydrogen ions (H+) through fluorescence signals by targeting the lysosome, a method for preparing these two-photon probes, and a method for separately or simultaneously imaging calcium ions in the cytoplasm, mitochondria, or plasma membrane and hydrogen ions in the lysosome using the two two-photon probes.

Abstract: Disclosed is a monolithic 3D integrated circuit including a semiconductor substrate, a first semiconductor device formed on the semiconductor substrate, a dielectric layer covering the semiconductor substrate and the first semiconductor device, a wiring structure formed in the dielectric layer, and a second semiconductor device formed on the dielectric layer and including a seed layer including a 2D semiconductor material and a crystallized semiconductor layer on the seed layer.

Abstract: The present application provides a method for fully recycling kitchen waste by using Hermetia illucens L. and aerobic microorganisms. The method includes first performing solid-liquid separation on the kitchen waste; then using the filtrate obtained through separation to feed young larvae of Hermetia illucens L. to convert salt in the filtrate into body fluid of Hermetia illucens L. in a larval stage, and using the kitchen waste filter residue to feed 2nd-6th-instar larvae of Hermetia illucens L. respectively; separating insects and insect feces residue in a timely manner, so as to reduce a salt content of insect feces and improve transabdominal transformation efficiency of Hermetia illucens L. and quality of the insect manure; and finally implementing full resource utilization through aerobic composting and insect drying and sterilization treatment.

Abstract: Modulators of Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) are described as well as their use as therapeutic agents for disease, disorders, or symptoms thereof, including those where modulation of NR4A1 is implicated. Such disease and disorders include cancer.

Abstract: Disclosed are methods to prevent an occurrence of a high-grade serous ovarian cancer and/or breast cancer in a subject by administering a therapeutically effective amount of an antiprogestin to the subject.

Abstract: The present invention discloses a new class of trans-cyclooctenes (TCOs), “a-TCOs,” that are prepared in high yield via stereocontrolled 1,2-additions of nucleophiles to trans-cyclooct-4-enone, which itself was prepared on large scale in two steps from 1,5-cyclooctadiene. Computational transition state models rationalize the diastereoselectivity of 1,2-additions to deliver a-TCO products, which were also shown to be more reactive than standard TCOs and less hydrophobic than even a trans-oxocene analog. Illustrating the favorable physicochemical properties of a-TCOs, a fluorescent TAMRA derivative in live HeLa cells was shown to be cell-permeable through intracellular Diels-Alder chemistry and to washout more rapidly than other TCOs.

Abstract: A spatial modulation system and a method for generating training sequences are provided. The method for generating training sequences includes: obtaining a cross Z-complementary set (CZCS); and obtaining a training sequence matrix according to cross Z-complementary sequences in the CZCS. Therefore, a larger zero correlation zone (ZCZ) width can be constructed, and the constructed sequence set has flexible lengths.

Abstract: Process and device configurations are provided operating and designing an auxiliary advisory system for manufacturing control systems and machine operations. Systems and processes are configured to utilize adaptive learning and context awareness to provide auxiliary advising and to assess a manufacturing environment and infrastructure. Processes are provided to receive and process data for a machine operation and assess interactions relative to one or more of a worker, machine, machine component and material. The processes and systems may output advice to assist with existing manufacturing systems and to adapt to changes in manufacturing conditions and environmental constraints. Advisory system functions may also include anomaly detection and recognition of worker gestures to control operation of a machine and a manufacturing process. Processes are provided to integrate causal relationships of objects by self-labeling data into causality models for assessing machine operation.

Abstract: The present disclosure relates to a biomimetic chip for three-dimensionally simulating an endometrium, and an endometrium simulating method using the biomimetic chip. The biomimetic chip according to an embodiment of the present disclosure is a three-dimensional biomimetic chip including a plate, a plurality of chambers, and a plurality of posts, which are arranged between the plurality of chambers, wherein the plurality of chambers include channels in which different cells are cultured, are arranged on the plate to be parallel to each other in one direction, and are arranged adjacent to each other such that at least some sections communicate with each other.

Abstract: A method of predicting traffic information includes receiving a road image photographed by a vehicle that is moved on a road, and detecting an object for the vehicle from a plurality of frames included in the road image; tracking the object detected in the plurality of frames; checking a movement trajectory of the tracked object, and checking a movement direction corresponding to the movement trajectory of the object; and checking a number of vehicles for each movement direction on the basis of the checked movement direction.