Abstract: Provided herein is a method, apparatus, and system for teleoperated, functional electric stimulation actuated rehabilitative cycling. Methods may include: receiving, at a master system, rotational input generating master system sensor input having a master system cadence; providing the master system sensor input including the master system cadence to a controller based on the rotational input from a rehabilitation participant or a remote therapist received at the master system; receiving, at a slave system, rotational input from the rehabilitation participant generating slave sensor input having a slave system cadence; providing the slave system sensor input including the slave system cadence to the controller based on the rotational input from the participant received at the slave system; and providing, from the controller, feedback through the master system in response to a difference between the master system cadence and the slave system cadence.

Abstract: An exoskeleton leg is wearable by a person. The exoskeleton includes a thigh link configured to move in unison with the thigh of the person, a shank link rotatably coupled to the thigh link and comprising at least one tooth, and a locking block coupled to the thigh link and comprising a locking face. Moreover, when the at least one tooth of the shank link contacts with the locking face, the shank link is prevented from flexion motion relative to the thigh link, but is allowed to extend relative to the thigh link.

Abstract: A method of treating medium chain acyl-CoA dehydrogenase deficiency, very long chain acyl-CoA dehydrogenase deficiency, long chain hydroxyacyl-CoA dehydrogenase deficiency, trifunctional protein deficiency, or CPT II deficiency in a patient is provided comprising administering to the patient a therapeutic amount of a triglyceride or other conjugated fatty acid that bypasses or leads to an intermediate that bypasses the deficient enzyme. Amino acid-conjugated fatty acids also are provided as well as compositions comprising the amino acid-conjugated fatty acids.

Abstract: Disclosed are substituted aminoquinoline and aminopyridine compounds and their use as bacterial nitric oxide synthase (bNOS) inhibitors. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of using the compounds and pharmaceutical compositions for treating a subject having or at risk for developing a disease or disorder that is associated with bNOS activity.

Abstract: Disclosed are compounds having a monoterpenoid and/or phenylpropanoid moiety and methods of their making and use as pesticidal compounds, such as herbicides.

Abstract: Synthesis of a compound 4,4?-[(2-hydroxypropane-1,3-diyl)bis(oxy)]dibenzaldehyde and its use as an insecticidal agent.

Abstract: The present invention includes compositions and methods of for treating plants infected with fungal pathogens by contacting an infected plant or plant at risk of infection with a fungicidal composition comprising an fungicide selected from copper compound such as copper octanoate or copper hydroxide, or a triazole fungicide such as myclobutanil, propionazole, tebuconazole or epoxiconazole, an enhancer selected from apyrase inhibitors, e.g., N-(m-tolyl)-[1,1?-biphenyl]-4-sulfonamide, S-heptyl 2-oxo-2H-chromene 3-carbothioate, 3-(N-(4-bromophenyl) sulfamoyl)-N-(3-nitrophenyl)benzamide, or (E)-3-methyl-N-(1-(naphthalen-2-yl) ethylidene)benzohydrazide and, optionally, a phytologically-acceptable inert carrier.

Abstract: Novel lentivirus packaging systems engineered with a synthetic gene network having a positive feedback loop to amplify the expression of virus genes are provided. When co-transfected into a host cell with a transfer plasmid and envelope vector, extremely high viral titers are achieved when compared to transfection of a host cell with conventional third generation packaging systems. Methods for enhancing production of lentivirus, compositions comprising high titer lentivirus, and therapeutic methods based on delivery of lentiviral nucleic acid to target cells are also provided.

Abstract: A pharmaceutical composition capable of forming free burst release effect in-situ forming implant useful for injection inside bone injuries without surgery is provided. This pharmaceutical composition includes; biodegradable polymer, selective estrogen receptor modulator, organic solvent and liquid lipid, solidifies upon contacting with the surrounding medium and form solid implant with compact framework by in-situ phase separation method to deliver the selective estrogen receptor modulator. This compact framework restores the porous structure of the implant by time which is essential in promoting bone healing.

Abstract: Methods and systems for delivery of pulsated air to a user using a device including a flow generator to generate a continuous air flow, a first actuator comprising a pulsated flow delivery mechanism configured to generate a pulsated air flow from the continuous air flow based on a pre-determined duty cycle to vary a frequency of the pulsated air flow, a user interface configured to generate and deliver vortices of pulsated air to the user at the frequency of the pulsated air flow, and a set of tubing to couple the flow generator, the first actuator, and the user interface.

Abstract: The disclosed methods relate to forming microneedle arrays from a production mold that comprises a flexible mold material. The disclosed methods can be used to reproducibly manufacture undercut dissolvable and coated microneedle arrays with various shapes and structures.

Abstract: A sensor having improved shelf life is provided for determining concentration of a biomarker in a liquid sample. The sensor functions by electrochemical detection and requires use of a biomolecule, e.g., an enzyme that catalyzes an electron transfer reaction specific for the biomarker. The sensor requires use of a quaternary ammonium compound as a bio-linker. It further requires crosslinking of the biomolecule for improved stability.

Abstract: A device for detection of a cannabinoid in a sample includes a sensor including a substrate and a sensor medium on the substrate. The sensor medium includes at least one nanostructure, wherein at least one property of the sensor medium is dependent upon the presence of the cannabinoid on a surface of the sensor medium. The device further includes electronic circuitry including at least one measurement system in operative connection with the sensor to measure a variable relatable to the at least one property of the sensor medium dependent upon the presence of the cannabinoid.

Abstract: The disclosure is directed to a device that includes a cavity formed by a plurality of rails, the plurality of rails connected to both a first support and a second support, each at predetermined intervals about a circumference of the first support and the second support; and at least one particle detection device operably connected to each rail of the plurality of rails. The disclosure is also directed to a scanner that includes the device, and a processor.

Abstract: A method of x-ray fluoroscopy images a region of interest at distinct first and second imaging projection angles using digital subtraction x-ray fluoroscopic imaging with a fiducial marker board positioned in a field of view containing the region of interest to produce first and second sets of images. Image segmentation information is determined to identify an anatomical feature in the region of interest imaged in the first set of images and the second set of images. The region of interest is then imaged using x-ray fluoroscopic imaging, again with the fiducial marker board positioned in a third field of view containing the region of interest, but without digital subtraction, to produce a third set of images. A virtual image of the anatomical feature is projected onto the third set of images, computed from the image segmentation information and from a predetermined geometric relationship of markers within the fiducial marker board.

Abstract: A method of manufacturing a heart valve comprises: a step of injection moulding a first part of the heart valve from a first block-copolymer, wherein the injection moulding is performed at a temperature below an order-disorder transition temperature of the block copolymer, such that a phase structure is present in the molten block-copolymer; a step of injection moulding a second part of the heart valve from a second block-copolymer that is different to the first block-copolymer, by over-moulding over the first part to form an over-moulded structure, wherein the injection moulding is performed at a temperature below order-disorder transition temperatures for the first and second block copolymers, such that a phase structure is present in the molten second block-copolymer and remains present in the first block-copolymer; and a step of cooling the over-moulded structure, without heating it above the order-disorder transition temperatures between the step of injection moulding the second part and the step of cool

Abstract: Disclosed are a method and apparatus for random access using random beam-switching in a wireless network environment. The random access method using random beam-switching in a wireless network environment includes selecting a given preamble when receiving a synchronization signal block from a base station, transmitting, to the base station, a first message including the selected preamble by using a sequential beam-sweeping method, transmitting a third message for a connection request for uplink data transmission when receiving, from the base station, a second message responding to the transmitted first message, and completing a random access channel operation when receiving a fourth message responding to the transmitted third message.

Abstract: Embodiments of the present invention are directed to articles used as an artificial reef and/or used as a part of an artificial reef, methods of making the articles, methods of using the articles, and methods of forming artificial reefs. The articles include a top, at least one support member, and optionally, a base. In some embodiments, the water permeability of the top of the article is greater (and in some embodiments, at least 10% greater) than the water permeability of the support, the water permeability of the optional base, or both. In preferred embodiments, the top, support(s), and optional base are formed of concrete.

Abstract: Methods of identifying cattle having increased feed efficiency using a small panel of single nucleotide polymorphisms is provided. The method provides for using a thousand or less of such SNPs and includes using a panel of 250 or fewer SNPs. The method if useful with various cattle breeds including crossbred cattle. Provided are SNPs that are useful as markers with various traits associated with feed efficiency in cattle. Kits and methods of use are provided.

Abstract: The present invention pertains to fracture reduction technology and introduces a frame-type surgical robot for fracture reduction. This robot comprises a mobile end mechanism and a fixed end mechanism, connected by a connection component. The mobile end mechanism includes a traction component linked to a lifting component via a translation component, which in turn is connected to a flipping component through a swing component. The flipping component features a self-rotating component, equipped with a mobile end clamping component. The fixed end mechanism includes an auxiliary traction structure, auxiliary translation structure, hand-cranking lifting structure, auxiliary flipping structure, and a fixed end clamping component. During surgery, the robot is positioned above the operating bed to perform fracture reduction.