Patents Assigned to The University
  • Patent number: 9862801
    Abstract: A method for the manufacture of a polymer is provided, the method comprising: Providing a first monomer, the first monomer comprising a bicyclic diamine moiety, a first nucleophilic group provided on a carbon atom of an aromatic moiety, and a second nucleophilic group provided on a carbon atom of an aromatic moiety; Providing a bridging compound comprising at least two sites vulnerable to nucleophilic attack; and Contacting the first monomer with the bridging compound. Polymers made by said method and uses of such polymers are also disclosed.
    Type: Grant
    Filed: November 5, 2015
    Date of Patent: January 9, 2018
    Assignee: The University Court of the University of Edinburgh
    Inventors: Neil Bruce McKeown, Mariolino Carta
  • Patent number: 9861662
    Abstract: Methods of manufacturing a bone-derived extracellular matrix (bECM) product are provided. Also provided are bECM products and methods of using those products.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: January 9, 2018
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, The University of Nottingham
    Inventors: Stephen F. Badylak, Michael J. Sawkins, Kevin M. Shakesheff, Lisa J. White
  • Patent number: 9861652
    Abstract: 2?-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein Base is a purine or pyrimidine base; R1 is OH, H, OR3, N3, CN, halogen, CF3, lower alkyl, amino, loweralkylamino, di(lower)alkylamino, or alkoxy; R2 is H, phosphate, or a stabilized phosphate prodrug; acyl, or other pharmaceutically acceptable leaving benzyl, a lipid, an amino acid, peptide, or cholesterol; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: January 9, 2018
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Dennis C. Liotta, Chung K. Chu, J. Jeffrey McAtee, Junxing Shi, Yongseok Choi, Kyeong Lee, Joon H. Hong
  • Patent number: 9861600
    Abstract: The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound suitable for such use.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 9, 2018
    Assignee: Arizona Board of Regents, A Body Corporate Of The State Of Arizona Acting For An On Behalf Of The University of Arizona
    Inventors: Brian McKay, John A. Martens
  • Patent number: 9862877
    Abstract: Provided herein are inter alia novel compositions and methods having application in the field of enhanced oil recovery. In particular, the short hydrophobe compounds and mixtures thereof presented herein can be used, inter alia, for the recovery of a large range of crude oil compositions from challenging reservoirs.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: January 9, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Upali P. Weerasooriya, Gary A. Pope
  • Patent number: 9862692
    Abstract: Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogs having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: January 9, 2018
    Assignee: The University of Toledo
    Inventors: Viranga Tillekeratne, William Taylor, Sara Fedorka
  • Patent number: 9865894
    Abstract: A direct-electrochemical-oxidation fuel cell for generating electrical energy includes a cathode provided with an electrochemical-reduction catalyst that promotes formation of oxygen ions from an oxygen-containing source at the cathode, a solid-state reduced metal, a solid-state anode provided with an electrochemical-oxidation catalyst that promotes direct electrochemical oxidation of the solid-state reduced metal in the presence of the oxygen ions to produce electrical energy, and an electrolyte disposed to transmit the oxygen ions from the cathode to the solid-state anode. A method of operating a solid oxide fuel cell includes providing a direct-electrochemical-oxidation fuel cell comprising a solid-state reduced metal, oxidizing the solid-state reduced metal in the presence of oxygen ions through direct-electrochemical-oxidation to obtain a solid-state reducible metal oxide, and reducing the solid-state reducible metal oxide to obtain the solid-state reduced metal.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: January 9, 2018
    Assignees: The University of Akron, The Ohio State University
    Inventors: Steven S. Chuang, Liang Shih Fan
  • Patent number: 9864092
    Abstract: Disclosed herein methods for determining a property of a formation, for example, when well logging, by feeding a gadolinium tracer fluid into the formation, applying an emitted radiation to the formation to thereby produce a signal, such as a neutron signal, and capturing the signal from the formation.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: January 9, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Carlos Torres-Verdin, Erich Schneider
  • Patent number: 9865768
    Abstract: In one aspect, there is provided an apparatus including a light emitting diode. The apparatus may include a plurality of layers including a substrate layer, a buffer layer disposed on the substrate layer, a charge transport layer, a light emission layer, another charge transport layer, and/or a metamaterial layer. The other charge transport layer may have at least one channel etched into the other charge transport layer leaving a residual thickness of the other charge transport layer between a bottom of the etched channel and the light emission layer. A metamaterial layer may be contained in the at least one channel that is proximate to the residual thickness of the charge transport layer. The metamaterial may include a structure including at least one of a dielectric or a metal. The metamaterial may cause the light emitting diode to operate at higher frequencies and with higher efficiency.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 9, 2018
    Assignee: The Regents Of The University of California
    Inventors: Zhaowei Liu, Danyong Dylan Lu
  • Patent number: 9862607
    Abstract: Fabricating a nanofiber sheet, ribbon, or yarn by a continuous process that includes synthesizing a nanofiber forest in a forest growth region on a substrate, wherein the nanofiber forest comprises a parallel array of nanofibers, and further includes drawing said nanofibers from the nanofiber forest to form a primary assembly that is a sheet, ribbon or yarn. The substrate continuously moves from the furnace growth region into a region where the nanofibers in the forest are drawn.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: January 9, 2018
    Assignee: Board of Regents, The University of Texas System
    Inventors: Mei Zhang, Shaoli Fang, Ray H. Baughman, Anvar A. Zakhidov, Kenneth Ross Atkinson, Ali E. Aliev, Sergey Li, Chris Williams
  • Patent number: 9867286
    Abstract: A circuit board is described. The circuit board comprises an electrically insulating diamond material having a surface. The electrically insulating diamond material has at least one recess extending into only a portion of a thickness of the electrically insulating diamond material from the surface of the electrically insulating diamond material. The circuit board also comprises an electrically conductive material located at least partially within the recess.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 9, 2018
    Assignees: National ICT Australia Limited, The University of Melbourne
    Inventors: Samantha Lichter, Nicholas Apollo, David Garrett, Kumaravelu Ganesan, Hamish Meffin, Steven Prawer
  • Patent number: 9861619
    Abstract: Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the antibiotic activity of the antibiotic. In certain embodiments the antibiotic is a beta lactam. In further embodiments, the antibiotic is oxacillin. In additional embodiments, the potentiating compound is an inhibitor of vraSR operon expression. In specific embodiments, the bacterial infection involves an antibiotic-resistant bacteria.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: January 9, 2018
    Assignee: The University of Chicago
    Inventors: Robert S. Daum, Susan Boyle-Vavra
  • Patent number: 9865465
    Abstract: Nanocrystal thin film devices and methods for fabricating nanocrystal thin film devices are disclosed. The nanocrystal thin films are diffused with a dopant such as Indium, Potassium, Tin, etc. to reduce surface states. The thin film devices may be exposed to air during a portion of the fabrication. This enables fabrication of nanocrystal-based devices using a wider range of techniques such as photolithography and photolithographic patterning in an air environment.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: January 9, 2018
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Cherie R. Kagan, David K. Kim, Ji-Hyuk Choi, Yuming Lai
  • Patent number: 9861714
    Abstract: The present invention relates to compounds that are useful as metal ligands and which can be bound to a biological entity such as a molecular recognition moiety and methods of making these compounds. Once the compounds that are bound to a biological entity are coordinated with a suitable metallic radionuclide, the coordinated compounds are useful as radiopharmaceuticals in the areas of radiotherapy and diagnostic imaging. The invention therefore also relates to methods of diagnosis and therapy utilizing the radiolabelled compounds of the invention.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: January 9, 2018
    Assignee: The University of Melbourne
    Inventors: Paul Donnelly, Brett Paterson
  • Patent number: 9864392
    Abstract: A CMOS voltage reference is disclosed. The CMOS voltage reference may include a PTAT current bias circuit including a start-up circuit, a core module implementing high order non-linear curvature compensation and an output stage supplying the reference voltage. The CMOS voltage reference may include a PTAT current bias circuit having a start-up and a CTAT feedback loop and a PTAT feedback loop and a compensating circuit summing the current from the CTAT feedback loop and the PTAT feedback loop.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: January 9, 2018
    Assignee: The University of Cyprus
    Inventors: Julius Georgiou, Charalambos Andreou
  • Patent number: 9865102
    Abstract: A system and method to preserve the integrity of data being extracted from an electronic data recorder (“EDR”) of an electronic control module (“ECM”) makes use of a forensic link adapter and, optionally, a sensor simulator (when ECM is out of the vehicle). The forensic link adapter has one or more first microprocessors and a first software means which prevent any message being sent by an external network from corrupting the previously recorded data measurements. The data measurements are then extracted, verified, and stored in a separate file. The sensor simulator has one or more second microprocessors, a second software means, and a bank of resistors that mimic sensors normally in communication with the ECM. The simulator “tricks” the ECM into thinking it is still in the vehicle by using the replicating vehicle system values the ECM normally sees when in the vehicle.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: January 9, 2018
    Assignee: The University of Tulsa
    Inventors: Jeremy Daily, James Johnson, Andrew Kongs, Jose Corcega
  • Patent number: 9861958
    Abstract: Embodiments relate to a cerium-containing nano-coating composition, the composition including an amorphous matrix including one or more of cerium oxide, cerium hydroxide, and cerium phosphate; and crystalline regions including one or more of crystalline cerium oxide, crystalline cerium hydroxide, and crystalline cerium phosphate. The diameter of each crystalline region is less than about 50 nanometers.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: January 9, 2018
    Assignee: The Curators of The University of Missouri
    Inventors: Matthew J. O'Keefe, Carlos E. Castano Londono, William G. Fahrenholtz
  • Publication number: 20180000755
    Abstract: An agent according to the present invention comprises as an effective component any of (1) disulfiram, diethyldithiocarbamate, or a metal complex of diethyldithiocarbamate; (2) a pharmaceutically acceptable salt of (1); or (3) a solvate of (1) or (2), and is used for inhibition of interaction between CR2B or CCR5 and FROUNT protein, inhibition of macrophages, control of cells constituting a cancer microenvironment or inflammatory microenvironment, or enhancement of anticancer activity of an anticancer drug. It is also possible to provide a compound with a reduced side effect and an increased pharmacological effect by identifying a disulfiram derivative having a lower aldehyde dehydrogenase-inhibiting activity and a higher FROUNT-inhibiting activity among derivatives prepared by structural modification of disulfiram.
    Type: Application
    Filed: January 6, 2016
    Publication date: January 4, 2018
    Applicant: The University of Tokyo
    Inventors: Yuya TERASHIMA, Kouji MATSUSHIMA, Etsuko TODA, Hiroaki TERASAWA, Sosuke YOSHINAGA
  • Publication number: 20180002685
    Abstract: Methods and compositions relating to the engineering of an improved protein with methionine-?-lyase enzyme activity are described. For example, in certain aspects there may be disclosed a modified cystathionine-?-lyase (CGL) comprising one or more amino acid substitutions and capable of degrading methionine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with methionine depletion using the disclosed proteins or nucleic acids.
    Type: Application
    Filed: March 6, 2017
    Publication date: January 4, 2018
    Applicant: Board of Regents, The University of Texas System
    Inventors: George GEORGIOU, Everett STONE, Wei-Cheng LU
  • Patent number: 9854790
    Abstract: The present invention relates to methods and compositions useful for the prevention and/or treatment of PRRS in animals, typically domestic pigs. The invention relates to proteins which comprise fragments of CD163, nucleic acid constructs encoding such proteins, and methods of modifying expression or activity of CD 163 in vivo.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: January 2, 2018
    Assignee: The University Court of the University of Edinburgh
    Inventors: Tahar Ait-Ali, Simon Lillico, Alan Archibald, Christopher Bruce Alexander Whitelaw