Abstract: The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).

Abstract: Provided herein, in some embodiments, are artificial ribosomes that synthesize nonribosomal peptides, polyketides, and fatty acids with full control over peptide sequence. Also provided herein are methods for programmed synthesis of nonribosomal peptides, polyketides, and fatty acids. In particular, provided herein are methods for scalable synthesis of a wide range of antibacterial, antifungal, antiviral, and anticancer compounds.

Abstract: Methods for creating nanostructured surface features on polymers and polymer composites involve application of low pressure during curing of solid polymer material from a solvent solution. The resulting nanoscale surface features significantly decrease bacterial growth on the surface. Polymer materials having the nanoscale structuring can be used in implantable medical devices to inhibit bacterial growth and infection.

Abstract: Medical devices comprising applicators that present a microneedle array and a separate electroporation array configured to simultaneously contact a tissue surface, a fluidic system connected to the microneedle array, and an electronic system connected to the electroporation array, for the coordinated delivery of a fluid biologic and electroporation energy to a tissue.

Abstract: The present invention provides a method for inducing an inversion of normal blood coagulation factor VIII (F8) gene, a method for correcting an inversion of blood coagulation factor VIII gene in which the inversion has occurred, and a Hemophilia A patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the F8 gene, which is responsible for the majority of severe hemophilia A, and thereby may be effectively used for studying the development mechanism of hemophilia A and as a research tool for screening therapeutic agents. The inversion-corrected induced pluripotent stem cell constructed according the method of the present invention enables an efficient and fundamental treatment for hemophilia A by restoring a genotype in which mutation has occurred to a wild type-like state, without limitation via normal gene or protein delivery.

Abstract: The present invention relates a haptic tool system, the system including: a computer device portion providing a content image including a target object for user testing or learning through a haptic feedback simulation function; and a haptic drill tool having an capacitive touch pen that makes contact with the target object and providing a haptic feedback simulating use of an actual drill to the user on the basis of load cell displacement information on a force applied according to the contact of the capacitive touch pen and physical property information on the target object. According to the haptic tool system, it is possible to provide the haptic feedback similar to a force and a motion sensation that the user feels when using an actual electric drill.

Abstract: A sensor includes a planar T-resonator and an oscillator. The planar T-resonator can be a branched T-resonator with at least two symmetrical branches coupled to a stub. The oscillator has an input coupled to the planar T-resonator and an output. The oscillator has a negative resistance within a predetermined frequency range. The oscillator can be configured so that it has an input phase approximately equal to a phase of the planar T-resonator over a majority of the predetermined frequency range.

Abstract: Certain embodiments involve processes or systems for creating various high-temperature superconductive structures or materials. For example, a method can involve depositing a first layer of boron and a second layer of un-doped amorphous carbon on a substrate. The un-doped amorphous carbon is ferromagnetic. The first layer of boron and the second layer of un-doped amorphous carbon are melted by a laser pulse to form a melted boron-doped amorphous carbon. The melted boron-doped amorphous carbon is quenched to create a quenched boron-doped amorphous carbon that is diamagnetic and superconducting. The quenched melted boron-doped amorphous carbon includes a mixture of sp3 bonded carbon atoms and sp2 bonded carbon atoms and a superconducting transition temperature of the quenched boron-doped amorphous carbon is much higher than diamond and increases based on a boron concentration. Undoped Q-carbon is ferromagnetic with Curie temperature above 500K.

Abstract: Compounds and methods for determining transmembrane potential, monitoring changes in transmembrane potential, and/or drug screening are provided. In one aspect, compounds of the invention have a structure according to the formula: E-M-A, wherein A is a fluorophore, selected from xanthenes, coumarins, cyanines, bimanes, and difuloroboradizaindacenes, charged at physiological pH; M is a molecular wire; and E is a hydrophobic moiety, wherein A and E are capable of being involved in a photo-induced, intramolecular electron transfer that quenches the fluorescence of A in response to a voltage condition. When in use, compounds of the invention are membrane-impermeant and oriented within the cell membrane such that the charged moiety localizes at the outer leaflet of the lipid bilayer and the hydrophobic moiety and molecular wire associate with the hydrophobic portion of the lipid bilayer.

Abstract: Multilayer thin film devices that include a bioactive agent for elution to the surrounding tissue upon administration to a subject are provided. The multilayer thin film devices are useful as medical devices, such as ocular devices. Also provided are methods and kits for localized delivery of a bioactive agent to a tissue of a subject, and methods of preparing the subject devices. The multilayer thin film medical device includes a first layer, a bioactive agent and a second layer. The first and the second layers may be porous or non-porous. The devices have a furled structure, suitable for administration to a subject.

Abstract: A magnetic-resonance-imaging-compatible (MRI-compatible) cardiac defibrillator includes: a defibrillator generator; first and second electric wires, each being electrically connected to said defibrillator generator; first and second defibrillation pads, each being electrically connected to a respective one of said first and second electric wires; and a low pass filter electrically connected between said defibrillator generator and said first and second electric wires to prevent a noise in an MRI image caused by a radiofrequency interference from the defibrillator as well as protect a patient and the defibrillator from MRI radiofrequency imaging signals, wherein said low pass filter has a cutoff frequency set such that differential mode noise at an MRI Larmor frequency is in an attenuated band while a system-test signal by said defibrillator generator is in a pass band of said low pass filter.

Abstract: Nanostructured aluminosilicates including aluminosilicate nanorods are formed by heating a geopolymer resin containing up to about 90 mol % water in a closed container at a temperature between about 70° C. and about 200° C. for a length of time up to about one week to yield a first material including the aluminosilicate nanorods. The aluminosilicate nanorods have an average width of the between about 5 nm and about 30 or between about 5 nm and about 60 nm or between about 5 nm and about 100 nm, and a majority of the aluminosilicate nanorods have an aspect ratio between about 2 and about 100.

Abstract: An oil gel capsule includes an oil gel including an oil and a gelator, and at least one surfactant bonded to the oil gel. A contact part for a vehicle includes an overlay layer formed on a surface of the contact part, the overlay layer comprising oil gel capsules, wherein the oil gel capsules including an oil gel including an oil and a gelator, and at least one surfactant bonded to the oil gel.

Abstract: Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided.

Abstract: The present invention relates to a negative pressure generating device and an automatic negative pressure wound therapy device having a pressure changing function using the same. The present invention includes a static load elastic unit which provides an elastic force having a predetermined magnitude; a rotating unit which is connected to the static load elastic unit to rotate by the static load elastic unit; and a negative pressure cylinder which is connected to the rotating unit and interworks with the rotation of the rotating unit to generate a negative pressure therein. According to the present invention, a constant negative pressure may be consistently generated by a mechanical structure so that a manufacturing cost is significantly reduced as compared with an electrical structure and the size may be reduced.

Abstract: A cell culture container includes a storage container, a cell culture area, a culture solution supply unit, and a discharge unit. The cell culture area is a region for culturing cells, and is provided in the storage container. The culture solution supply unit supplies the culture solution into the cell culture area at a flow rate equal to or less than a predetermined flow rate. The discharge unit discharges the liquid in the cell culture area to the outside of the storage container. A rectification unit is a structure in which a plurality of outflow ports are uniformly arranged in a direction perpendicular to the flow direction of the culture solution from the culture solution supply unit to the discharge unit.

Abstract: Provided is room temperature stable ?-phase Bi2O3. Ion conductive compositions comprise at least 95 wt % ?-phase Bi2O3, and, at 25° C., the compositions are stable and have a conductivity of at least 10?7 S/cm. Related methods, electrochemical cells, and devices are also disclosed.

Abstract: Described are systems for spatial cognitive ability assessment wherein a subject is able to manipulate one or more object(s) that is monitored by a device for recording motion attached to the object(s), the subject, or both that is able to generate motion electronic data. Also described are methods for assessing spatial cognitive ability.

Abstract: The present disclosure provides a mechanically-actuated tool for cutting a tissue graft having a hollow core and methods for use thereof. A portion of a biological structure, such as a nerve, is attached to the hollow core to form an implantable neural graft assembly. The tool has a cutter mechanism and a grasper mechanism. The grasper mechanism has one or more component(s) that open and close via an actuation mechanism, like a handle, and rotate via a controller component, like a rotatable wheel. The cutter mechanism may be a cutting tube component that harvests the tissue graft. The tool may also have an ejector mechanism to remove the tissue graft as part of the implantable neural graft assembly. Such devices and methods are particularly suitable for treating neuromas and other neural regeneration procedures.

Abstract: Image decoding of decoding a sequence of coded pictures on a block-by-block basis is provided. The image decoding incudes decoding a first high-level syntax element from a bitstream to determine, at a sequence level, whether affine motion prediction is allowed. A second high-level syntax element is extracted for each of at least one coding tool from the bitstream depending on the first high-level syntax element. At a picture level, the method determines whether each of the at least one coding tool is allowed. The coding tool includes sample-by-sample adjustment of affine motion prediction samples.