Abstract: The present technology generally relates to stopped-flow microfluidic devices. Select embodiments of the present technology include microfluidic devices having a first porous element configured to receive a first fluid and a second porous element configured to receive a second fluid. The second porous element can have one or more legs overlapping with the first porous element. The device can be configured such that (a) delivery of the first fluid to the first porous element causes the first fluid to flow along the length of the first porous element without substantially wetting the one or more legs, and (b) delivery of the second fluid to the second porous element causes the second fluid to flow into the overlapping regions of the first porous element, thereby substantially stopping flow of the first fluid along at least a portion of the first porous element.

Abstract: A Quantum Digital Signature (QDS)-based mail system and a transceiving method are provided. The system is a three-layer structure formed by a physical layer, a key layer, and an application layer. The physical layer is a key generation terminal and is used to generate a key string for signature in real time; the key layer is used to store the key string generated by the physical layer and provide a required key to the upper layer, namely, the application layer when required; and the application layer is a transceiving software part in the mail system, and is used to extract keys generated by the physical layer from the key layer so as to encrypt information to be sent. The mail transceiving method comprises: a quantum key distribution (QKD) phase, a mail signature phase, and a signature verification phase.

Abstract: A pump-out tube for evacuating a space between two sheets of glass, the pump out tube being receivable in a hole formed in at least one of the sheets of glass, the pump out tube formed as a separate element comprising a tubular member and a seal formed around the tube.

Abstract: Aldoketo reductase (AKR) inhibitors having formulas I-III are used to treat disorders associated with NO/SNO deficiency.

Abstract: Provided are an organic thin film transistor, an organic semiconductor film, a compound, an organic thin film transistor-forming composition, and a method of manufacturing the organic thin film transistor. The organic thin film transistor includes the organic semiconductor film. The organic semiconductor film includes a compound represented by a specific formula. The organic semiconductor film, the compound, and the organic thin film transistor-forming composition can be preferably used in the organic thin film transistor. The method of manufacturing the organic thin film transistor includes a step of forming an organic semiconductor film by applying the organic thin film transistor-forming composition to a substrate.

Abstract: The invention relates to tau, to antibodies and related fragments thereof for binding to tau, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, including tauopathies. The invention also relates to compositions comprising tau antibodies for binding to tau and their use in combination with acoustic energy.

Abstract: A method for encoding image signal, according to the present invention, can: encode a partial block coefficient flag indicating whether a coefficient of a current partial block is a non-zero coefficient; encode a first flag indicating whether an absolute value of the coefficient is greater than 1, encode a second flag indicating whether the absolute value of the coefficient is greater than 2; encode the residual coefficients, which have not been encoded, on the basis of the first flag or the second flag in the current partial block; and encode a code for the coefficient of the current partial block.

Abstract: The present invention provides an augmented reality service providing device, including: a sensing unit to photograph an object and to measure a current position of a mobile terminal; a communication unit to measure a communication distance between the mobile terminal and the object; a control unit to control to repeat a plurality of times the measurement of the current position and the communication distance while the mobile terminal is moving; a calculation unit to calculate an estimated position of the object based on the current position and the communication distance measured repeatedly a plurality of times; and a display unit to display virtual information on the object on the estimated position of the object.

Abstract: The present invention discloses a vehicle-mounted large-flow fire-fighting foam fluid mixing system, including a supply kit, a mixing kit, a control kit, and a pipeline kit. The supply kit includes an auxiliary gas supply device, a fire pump, an integrated foam pump, a fire pump main motor, and a coupling. The mixing kit includes a fire monitor interface, a foam generating device, and a fluid mixing device. The control kit includes a foam mixing proportion single-chip microcomputer control system, an alarm module, a power module, an auxiliary air compressor switch module, a frequency converter, and a central control display screen. The pipeline kit includes an air drainage tube, a fire hose, a foam liquid pipe, and a pipeline valve. For the problems of flow fluctuation and low foam foaming efficiency, the present invention optimizes the design and adopts a new control policy, thereby implementing precise mixing under the large-flow condition.

Abstract: A device may obtain field images of a tissue sample, apply, to the field images, spatial distortion and illumination-based corrections (including corrections for photobleaching of reagents) to derive processed field images, identify, in each processed field image, a primary area including data useful for cell or subcellular component characterization, identify, in the processed field images, areas that overlap with one another, and derive information regarding a spatial mapping of cell(s) and/or sub-cellular components of the tissue sample. Deriving the information may include performing segmentation based on the data included in the primary area of each processed field image, and obtaining flux measurements based on other data included in the overlapping areas.

Abstract: A method for detecting a target nucleic acid includes: (a) a step of mixing a sample containing the target nucleic acid with a nucleic acid detection solution containing i) ssDNA-protease conjugate, ii) ssDNA-zymogen conjugate, and iii) a substrate specific for the zymogen; and (b) a step of detecting a signal generated by a proximity proteolysis reaction between the ssDNA-zymogen conjugate and the ssDNA-protease conjugate which are hybridized to the target nucleic acid.

Abstract: An encryption method and apparatus based on homomorphic encryption using an odd function property. The encryption method includes generating a ciphertext by encrypting data, and bootstrapping the ciphertext by performing a modular reduction based on an odd function property for a modulus corresponding to the ciphertext.

Abstract: Disclosed are methods and compositions related to methods of treating, ameliorating, mitigating, slowing, arresting, preventing or reversing various diseases and conditions, including age-related obesity, age-related increases in blood lipid levels, age-related decreases in insulin sensitivity, age-related decreases in memory function, and age-related changes in eye function such as macular degeneration. The methods comprise administering nicotinamide mononucleotide (NMN) to a subject. In some embodiments, the administration can be oral administration. Also disclosed are pharmaceutical compositions comprising NMN.

Abstract: The present subject matter provides processes and kits for identifying the presence of waste water or human-derived pathogens, particularly those associated with the presence of human fecal matter, in surface or subsurface water sources.

Abstract: The present specification discloses a method of decoding an image. The method includes performing dequantization on a current block to obtain a transform coefficient of the current block; performing at least one inverse transform of primary inverse transform and secondary inverse transform on the transform coefficient of the current block to obtain a residual block of the current block; and adding the residual block of the current block and a prediction block of the current block to obtain a reconstructed block of the current block, wherein the secondary inverse transform is performed only when the current block is in an intra prediction mode.

Abstract: The invention comprises the administration of a remyelinating agent to treat a demyelinating condition, such as MS. Disclosed are various remyelinating compositions which promote remyelination, oligodendrocyte differentiation, and the treatment of demyelinating conditions such as MS. In one aspect, the remyelinating compositions are selective estrogen receptor modulators with remyelinating properties. In one aspect, the remyelinating compositions are agonists of GPR56, a G-protein coupled receptor which has not previously been identified as an effector of remyelination.

Abstract: The present disclosure provides polynucleotides and vectors for the genomic engineering and editing of non-conventional yeasts such as Issatchenkia orientalis. The polynucleotides and vectors can be used as tools that are efficient to alter the expression of one or more gene products in the yeast, and specifically to induce the production of organic acids or other bioproducts of interest in the yeast.

Abstract: The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The compositions may comprise peptides. The methods described herein include administering a composition comprising an epitope of a peptide to a subject in need thereof.

Abstract: Various embodiments of a system and method for pruning binary neural networks by analyzing weight flipping frequency and pruning the binary neural network based on the weight flipping frequency associated with each channel of the binary neural network are disclosed herein.

Abstract: The present disclosure provides methods to quantify VCP phosphorylation at specific amino acid residue to predict responsiveness of a subject having a cancer or tumor to a genotoxic treatment, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.