Abstract: Methods for antibody profiling and epitope mapping are provided herein. More particularly, methods for screening and mapping epitopes of candidate antibodies and protein target identification are provided herein.

Abstract: Provided herein are methods and devices for controlled metering of a volume of fluid into a bioreactor chamber by use of a thermally-activated actuator that provides simultaneous temperature control and fluidic valve capability. The device may be an elastomeric valve assembly comprising: a thermally-activated actuator, a microfluidic cartridge and an elastomeric membrane operably connected to the thermally-activated actuator. Upon thermal activation of the thermally-activated actuator the elastomeric contact surface is forced into a lumen of the conduit of the microfluidic cartridge to fluidically seal the conduit, while the thermally-activated actuator is in thermal contact with a bioreactor chamber.

Abstract: A production line for recycling and processing waste materials of steel rolling, the production line including: an electromagnetic hoisting equipment; a conveying platform; a clamping-and-feeding device; a segmentation shear; a swing conveyor device; a pushing device; a rolling-type shearing machine; a chain-type conveyor track; a material guiding device; two shredding-type shearing machines; and a scrap collection device. The electromagnetic hoisting equipment is connected to the conveying platform, and is configured to hoist waste materials of steel rolling to the conveying platform; the conveying platform is connected to the clamping-and-feeding device, and is configured to convey the waste materials to the clamping-and-feeding device; the segmentation shear cooperates with the clamping-and-feeding device and is configured to segment the waste materials of steel rolling into steel plates; the pushing device is configured to push the steel plates to the rolling-type shearing machine.

Abstract: A neural network processing system includes at least one synapse and a neuron circuit. The synapse receives an input signal and has an external weighted value and an internal weighted value, and the internal weighted value has a variation caused by an external stimulus. When the variation of the internal weighted value accumulates to a threshold value, the external weighted value varies and the input signal is multiplied by the external weighted value of the synapse to generate a weighted signal. A neuron circuit is connected with the synapse to receive the weighted signal transmitted by the synapse, and calculates and outputs the weighted signal. The present invention can simultaneously accelerate the prediction and learning functions of the deep learning and realize a hardware neural network with high precision and real-time learning.

Abstract: Described are positive allosteric modulators of muscarinic acetylcholine receptor M1(mAChR M1), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating neurological disorders, psychiatric disorders, or a combination thereof.

Abstract: Single-layer LEDs were developed using a composite thin film of organometal halide perovskite (Pero) and poly (ethylene oxide) (PEO). Single-layer Pero LEDs have a device structure that resembles “bottom electrode (ITO)/Pero-PEO/top electrode (In/Ga or Au)”. Green emission LEDs with methylammonium lead bromide (bromide-Pero) and PEO composite thin films exhibit a low turn-on voltage of about 2.8-3.1 V (defined at 1 cd m?2 luminance), a maximum luminance of 4064 cd m?2 and a moderate maximum current efficiency of about 0.24-0.74 cd A?1. Blue and red emission LEDs have also been fabricated using Cl/Br or Br/I alloyed Pero-PEO composite thin films.

Abstract: A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive aldehydes and/or inhibit diabetes-induced superoxide generation and capillary degeneration regulated by GPCR signaling pathways.

Abstract: A method comprises depositing forming a first oxide layer comprising a bottom surface in contact with a first electrode, positioning a template at a specified position on a top surface of the first oxide, the template comprising a plurality of nanopores that extend through the template, depositing a metal material into at least a portion of the plurality of nanopores, allowing the metal material to at least partially solidify in at least the portion of the plurality of nanopores to form nanostructures in contact with the first oxide top surface, separating the template from the first oxide layer and the nanostructures, forming a second oxide layer comprising a bottom surface in contact with the first oxide top surface and the nanostructures, and forming a second electrode in electrical contact with at least a portion of a top surface of second oxide top surface.

Abstract: Volumetric imaging with selective volume illumination (SVI) using light field detection is provided using various systems and techniques. A volumetric imaging apparatus includes a light source configured to emit an illumination light that propagates via an illumination light path to illuminate a three-dimensional (3D) sample; and an optical system arranged with respect to the light source to receive a light field, which comes from the illuminated 3D sample. The light field propagates via a detection light path, and the light source, the optical system, or both; are configurable to perform SVI, which selects a volume of a 3D-confined illumination of the 3D sample based on the 3D sample to be illuminated and a light field detection (LFD) process to be applied. Further, the volume of the 3D-confined illumination is a selected 3D volume of the 3D sample to be particularly excited by the 3D-confined illumination for imaging.

Abstract: Apparatus and methods for powering micron-scale implantable and injectable integrated circuit (IC) chips for in-vivo sensing and acquisition of various physiological signals are provided. The disclosed subject matter includes the integration of piezoelectric transducers, such as polyvinylidene fluoride (PVDF) or lead zirconate titanate (PZT), onto implantable and injectable IC chips for power transfer and data transmission using ultrasound waves generated from commercial ultrasound imaging equipment.

Abstract: A method for the rapid detection of the linear axis angular error of an NC machine tool, belongs to the technical field of NC machine tool testing. Firstly, the measuring device is mounted on the linear axis. Then, the linear axis moves at three different speeds at a constant speed, and the upper measurement system automatically performs multi-channel acquisition and storage of the motion measurement's point measurement data. Then, based on the same geometric error signal, it is decomposed into the different frequency components, and the measurement angle error is filtered at the different speeds. Finally, the measurement angle errors at the three speeds after filtering are superimposed to complete the rapid measurement of the linear axis angular error of the machine tool. The measurement efficiency is high and data processing capability is strong.

Abstract: A chalcogenide film is provided. The chalcogenide film includes a noble metal chalcogenide material having a formula MCx. M represents a noble metal. C represents a chalcogen. x is any one positive value equal to or more than 1.4 and less than 2. The chalcogenide film is configured to generate electrons and holes upon light incident on the chalcogenide film.

Abstract: A method including providing a digital image from a camera imaging sensor wherein the image comprises both low resolution multispectral and panchromatic information; interpreting the digital image to obtain a low resolution multispectral digital image, interpreting the digital image to obtain a high resolution monochromatic digital, fusing the low resolution multispectral digital image and the high resolution monochromatic digital image to produce a high resolution colour image.

Abstract: The present invention concerns protection of an organ or tissue outside of the central nervous system following an ischemic episode. In particular aspects, the invention concerns organ preservation for transplantation, angina pectoris, kidney reperfusion injury, and so forth. In specific embodiments, the organ is subjected to an inhibitor of an NCCa-ATP channel that is regulated by SUR1. Exemplary inhibitors include sulfonylurea compounds, such as glibenclamide, for example.

Abstract: The present invention is concerned with prenatal screening and in particular non-invasive prenatal screening, as well as primers, primer sets and kits. In one instance, the invention provides a method of prenatal screening comprising: (a) amplifying a region encompassing the site of a mutation site responsible for the disorder, the amplification being performed on a DNA sample obtained from a pregnant female which comprises both maternal and fetal DNA; (b) sequencing a plurality of products from the amplification and determining whether or not the mutant allele is represented at a different frequency to that expected from the genotype of the pregnant female alone.

Abstract: The present invention relates to compositions and methods for preventing and/or treating bacterial disease (e.g., disease caused by Neisseria sp. such as gonorrhea). In particular, the present invention provides compositions comprising an effective amount of a nucleic acid, wherein such compositions are capable of killing or inhibiting the growth of a Neisseria sp. (e.g., Neisseria gonorrhoeae).

Abstract: Methods, systems, and computer readable media for compiling concise expressive design patterns within computer software source code are described. Some implementations can include methods and systems that resolve some problems of implementing design patterns in an OO and/or AO program. The disclosed technique facilitates writing programs that apply design patterns to its structure and behavior, in an easy manner. Some programming language constructs (associated with new keywords, syntax, and semantics) are disclosed that convey the goal of some design patterns in order to allow programmers to implement design patterns simply and concisely. These constructs are added as extensions to a compiler and a compiler-based approach to concise expressive design pattern source code is described.

Abstract: An optical system including a layer having a reflective surface, the layer is adapted to provide a primary image and a secondary image. The secondary image is provided by a reflection of an object facing the reflective surface, and the primary and the secondary images are viewable by a viewer having a retina. The secondary image is focused in front of the retina to generate myopic defocus.

Abstract: A seawater desalination device of industrial exhaust heat-driven ejector refrigeration and an application method thereof. The seawater desalination device comprises a seawater collecting pool, a low-pressure seawater storage tank, an ejector refrigeration system and a fresh water storage tank which are fluidly connected; the ejector refrigeration system comprising a nozzle for spraying low-pressure vapor, a mixing chamber, a diffuser, a first heat-exchanger, a condenser, a condensate pump and a generator; bottom of the low-pressure seawater storage tank being connected with a second heat-exchanger; the mixing chamber being connected with the nozzle, the diffuser and the low-pressure seawater storage tank, respectively; and the diffuser, the first heat-exchanger, the condenser and the fresh water storage tank being successively connected.

Abstract: In one aspect, composite polymeric composition and related materials are described herein employing waste products from the agricultural and energy industries. Such composite polymeric compositions and materials can repurpose agricultural and petroleum waste products for various applications including, but not limited to, building and/or infrastructure materials. In some embodiments, a composite polymeric composition described herein comprises polysaccharides, lignin or combinations thereof covalently cross-linked via linkages comprising sulfur.