Abstract: A hydrocracking catalyst for petroleum hydrocracking is provided, the hydrocracking catalyst provided in a form of at least one fiber, and the at least one fiber comprising at least one zeolite and at least one metal oxide. Methods are also provided to form the hydrocracking catalyst in the form of at least one fiber, particularly electrospinning.

Abstract: Various methods and systems are provided for cerebral diagnosis. In one example, among others, a method includes obtaining EEG signals from sensors positioned on a subject; conditioning data from the EEG signals to remove artifacts; generating a cerebral network model based at least in part upon the conditioned data; determining network features based upon the cerebral network model; and determining a cerebral condition of the subject based at least in part upon the network features. In another example, a method includes determining a recording condition of a positioned EEG sensor and providing an indication of an unacceptable recording condition of the EEG sensor. In another example, a system includes an EEG recording module to acquire signals; a signal conditioning module to condition signal data; a signal analysis module to determine signal features and cerebral network features; and a condition classification module to determine a cerebral condition of the subject.

Abstract: A device for performing tomosynthesis in real time is described. Multiple imaging sources (such as x-ray sources) may be energized in parallel and collimated towards a field of view. Objects within the field of view cast shadows onto one or more detectors. An imaging system may read the one or more detectors and acquire multiple views corresponding to the multiple imaging sources to produce a reconstructed image of an object of interest. From this reconstructed image, a target of the radiation therapy can be located, and the delivery of the radiation can be adjusted, as needed. The approach provides a real-time tomosynthesis design that can produce enhanced contrast for guidance of, for example, lung tumor treatment. Higher frame rates can be achieved to better compensate for changes in the position of the target during radiation therapy due to, for example, respiratory or cardiac motion.

Abstract: A device for processing microstructure arrays of polystyrene-graphene nanocomposites, including a laser generator, a vacuum chamber, an object stage, an ultraviolet filter and a gas flow control unit. The object stage is detachably fixed to a bottom of the vacuum chamber with a passage that can be opened or closed. The ultraviolet filter is provided in the vacuum chamber. A laser light emitted by the laser generator arrives at the object stage through the ultraviolet filter. The object stage is configured to place a sample to be processed. The gas flow control unit is communicated with the vacuum chamber and is configured to control the flow of the gas entering the vacuum chamber. The vacuum chamber is fixed on a three-axis precision positioning platform via a vacuum chamber clamp. The device disclosed herein aims to solve the existing difficulty in processing microstructure arrays of polystyrene-graphene nanocomposites.

Abstract: A mobile microalgae harvesting apparatus is disclosed. In one embodiment the mobile microalgae harvesting apparatus includes a harvesting boom coupled to a harvesting vessel, where the harvesting boom skims a microalgae mixture of microalgae and water from a surface of a body of water down to a predetermined depth below the surface. In the embodiment, the mobile microalgae harvesting apparatus also includes a separator aboard the harvesting vessel that separates water from the microalgae mixture and a microalgae collector that collects microalgae from the separator, wherein the microalgae collector deposits the collected microalgae on a transfer vessel coupled to the harvesting vessel. A mobile microalgae harvester and a system for harvesting microalgae are also disclosed.

Abstract: Provided herein are metal organic frameworks comprising metal nodes and N-donor organic ligands. Methods for capturing chemical species from fluid compositions comprise contacting a metal organic framework characterized by the formula [MaMbF6-n(O/H2O)w(Ligand)x(solvent)y]z with a fluid composition and capturing one or more chemical species from the fluid composition.

Abstract: A biosensor device for the real-time detection of a target analyte includes a receptor component operatively connected to a transducer component which is adapted to interpret and transmit a detectable signal. The receptor component includes a sensing element capable of detecting and binding to at least one target analyte, and a self-assembled monolayer (SAM) layer. The SAM layer is positioned between and in contact with the sensing element and an electrode such that the sensing element, in the presence of the target analyte, causes a detectable signal capable of being transmitted to the electrode. The transducer component includes the electrode and microprocessor configured to screen noise and to pick up impedance change at a very low frequency range.

Abstract: An immune-modulating biomaterial comprising a hydrogel scaffold coupled to D-amino acid containing peptides having unexpected properties in vivo is described. For example, certain inflammatory reactions in vivo are significantly increased around the D-peptide containing particles of hydrogel scaffold as compared to particles that contain both L and D peptides or L peptides alone. In addition, these D-peptide compositions are further observed to enhance wound healing and improve the tensile strength of healed tissues. For these and other reasons, the D-amino acid hydrogel materials disclosed herein are useful in a number of methodologies that seek to modulate the immune response and/or wound healing.

Abstract: The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.

Abstract: An imaging and display system for guiding medical interventions includes a wearable display, such as a goggle display, for viewing by a user. The display presents a composite, or combined image that includes pre-operative surgical navigation images, intraoperative images, and in-vivo microscopy images or sensing data. The pre-operative images are acquired from scanners, such as MRI and CT scanners, while the intra-operative images are acquired in real-time from a camera system carried by the goggle display for imaging the patient being treated so as to acquire intraoperative images, such as fluorescence images. A probe, such as a microscopy probe or a sensing probe, is used to acquire in-vivo imaging/sensing data from the patient. Additionally, the intra-operative and in-vivo images are acquired using tracking and registration techniques to align them with the pre-operative image and the patient to form a composite image for display by the goggle display.

Abstract: Disclosed is a method and apparatus relating generally to scalar atomic magnetometers. The disclosed methods and apparatus utilize a pressurized sample chamber and a high frequency pulsed pump laser to increase spin polarization and significantly suppress heading errors. These methods and apparatus may also include alternating polarization of the pump light between pulses.

Abstract: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.

Abstract: A phosphatidylserine targeted peptoid has been identified with the ability to bind to cancer cells globally and specifically. A dimer of the peptoid decreases cancer cell viability. Use of the dimerized peptoid enhances the efficacy of docetaxel. The peptoid can be used for including but not limited to diagnosing and treating cancer, diagnosing and treating a viral condition, and diagnosing and treating diabetes.

Abstract: Methods for decreasing rod gene expression in a retina, methods for decreasing the protein products expressed by rod genes in a retina, methods for treating a disease or condition treatable by decreasing rod gene expression or their protein products in a retina, and methods for treating a retinal disease in a subject.

Abstract: An apparatus is disclosed intended to expose a structure within a cavity of the human body for therapeutic and/or surgical treatment. The apparatus comprises an insufflator, comprising a gas output and an insufflator input mechanism adapted to input the gas from the gas output into the cavity of the human body, further comprising an insufflator controller for enlarging the cavity part by insufflation of gas from the gas output into the cavity; and a breathing rate detector; wherein the insufflator controller is arranged to real time adapt an insufflation frequency rate and flow in accordance with a detected or set breathing rate of the human body.

Abstract: Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13R?2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy cells. Exemplary specific binding molecules are bispecific binding molecules that comprise a fragment of an IL13R?2 binding molecule and a peptide providing a second function providing a signaling function of the signaling domain of a T cell signaling protein, a peptide modulator of T cell activation, or an enzymatic component of a labeling system. Also provided are polynucleotides encoding such a specific binding molecule (e.g., bispecific binding molecule), vectors, host cells, pharmaceutical compositions and methods of preventing, treating or ameliorating a symptom associated with a cancer disease such as a solid tumor disease (e.g., glioblastoma multiforme).

Abstract: Resonant power converters that replace the conventional impedance matching stage with series or parallel connections between resonant inverters and resonant rectifiers are provided. Two or more resonant rectifiers can be connected in series or in parallel to the resonant inverter to provide impedance matching. Similarly, two or more resonant inverters can be connected in series or in parallel to the resonant rectifier to provide impedance matching. Electrical isolation of DC voltage between input and output is provided using only capacitors.

Abstract: A biosensor electrode comprises comprising a porous structure comprising a plurality of metal ligaments and a plurality of pores; and at least one carbon nanotube structure embedded in the porous structure and comprising a plurality of carbon nanotubes joined end to end by van der Waals attractive force, wherein the plurality of carbon nanotubes are arranged along a same direction.

Abstract: An end treatment for a guardrail safety system includes a terminal portion of a guardrail beam comprising a downstream end and upstream end, a first tension cable coupled to an upstream end of the terminal portion. An extruder configured to receive at least a portion of the guardrail beam and at least a portion of the first tension cable, and a terminal support post installed adjacent the roadway at an upstream end of the terminal portion of the guardrail beam. The extruder includes a narrowing throat providing a channel in which at least a portion of the guardrail beam is disposed. The narrowing throat is configured to flatten the guardrail beam in response to a collision with a vehicle moving the extruder in a downstream direction along the guardrail beam. The terminal support post coupled to an upstream end of the first tension cable.

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.