Abstract: Methods for targeting adaptive responses to chemotherapy are described. In various embodiments, a method comprises administering at least one compound that inhibits S6K1, mTORC1 or upstream or downstream pathway components of S6K1 or mTORC1, in association with administration of at least one inhibitor of PPAR?, PPAR?, or PGC1?. In various embodiments, the compound that inhibits S6K1, mTORC1, or upstream or downstream pathway components of S6K1 or mTORC1 is rapamycin, everolimus, temsirolimus, or imatinib. The inhibitor of PPAR?, PPAR?, or PGC1? can be an antagonist or an inverse agonist selected from GW6471, GSK3787, GSK0660, and ST247.

Abstract: A small and inexpensive plasma actuator is capable of accelerating induced flow and increasing the effect of controlling flow. A plurality of electrode pairs are disposed on a dielectric layer upstream to downstream along a predetermined direction. Each electrode pair includes an upstream electrode disposed on one surface of the dielectric layer and a downstream electrode disposed on another surface of the dielectric layer to sandwich the dielectric layer between the upstream electrode. A lowest electrode is on the one surface of the dielectric layer displaced downstream from the downstream electrode in an the most downstream electrode pair to have the same potential as the downstream electrode. A voltage application device is configured to apply voltage including AC voltage or repeated pulse voltage to each electrode pair such that the potential of the applied voltage inverts at adjacent electrode pairs.

Abstract: A tissue punch including a barrel defining a first open end, a second open end, and inner diameter, an outer diameter, and a lumen there through. A piston is at least partially disposed within the lumen and pressed against the inner diameter of the barrel, the piston being configured to create negative pressure within the barrel when the piston is retracted. A cutting element defines a proximal end and a distal end, the proximal end of the cutting element being disposed at the second open end of the barrel, the distal end of the cutting element defining a cutting edge, the cutting element is in fluid communication with the barrel. A pushing element is slideably disposed about the outer diameter of the barrel, the pushing element is movable from a biased first position away from the cutting edge to a second position proximate the cutting edge.

Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 5 beta 1 and methods of using the same.

Abstract: A surgical instrument for the removal of frontal nasal recess cells includes an elongate handle, a first arm extending from a first end of the handle and a second arm extending from a second end of the handle. The first and second arms can extend in opposing directions. Each of the arms include a spherical terminal hub on their respective ends. A plurality of cylindrical fingers extend from each terminal hub at an angle, thereby providing an umbrella-like configuration. A spherical cap is attached to a free end of each cylindrical finger.

Abstract: In the field of computer vision, without sufficient labeled images, it is challenging to train an accurate model. But through visual adaptation from source to target domains, a relevant labeled dataset can help solve such problem. Many methods apply adversarial learning to diminish cross-domain distribution difference. They are able to greatly enhance the performance on target classification tasks. GAN (Generative Adversarial Networks) loss is widely used in adversarial adaptation learning methods to reduce a across-domain distribution difference. However, it becomes difficult to decline such distribution difference if generator or discriminator in GAN fails to work as expected and degrades its performance. To solve such cross-domain classification problems, an adaptation algorithm and system called as Generative Adversarial Distribution Matching (GADM) is implemented.

Abstract: Various aspects of a systems and method for reconstructing a surface of a three-dimensional (3D) target are disclosed herein. The method may comprise projecting a sequence of patterns to the surface of the target; capturing a first stereo endoscopic image and a second stereo endoscopic image from the patterns reflected from the surface; performing a coarse matching for the captured first and second stereo endoscopic images to acquire a set of matching candidates; and performing a precise matching for the acquired set of matching candidates to acquire reconstruction pixels for reconstructing the surface.

Abstract: The present disclosure provides recombinant microorganisms capable of sugar co-utilization, the recombinant microorganism comprising a genetically altered microorganism (e.g. S. cerevisiae) having a lack of, or reduced expression of, or expression of truncated or mutated forms of at least one polypeptide selected from Hxk1, Hxk2, and Glk1. Reduction of the expression or biological activity of Hxk1, Hxk2 and Glk1 leads to reduction in the glucose consumption pathway, allowing the microorganism to co-utilize multiple sugars (e.g. glucose, xylose, galactose) at an improved rate.

Abstract: A method for determining a quality of a friction stir welded seam is described. The method involves applying an impact to a welded plate and comparing its damping capacity with the damping capacity of a geometrically equivalent defect-free plate. Damping capacities that differ by a small percent difference indicate that the welded plate is also defect-free. This method is particularly advantageous when dealing with small defects, which produce miniscule changes in natural frequency which may not be measureable.

Abstract: A method of creating a composite cathode for use within a lithium ion battery. The method beginning with the step of preparing an electrolytic solution. The electrolytic solution includes a plasticizer, a crosslinkable polyether, a first lithium salt and a second lithium salt. The method ending with the step of impregnating a cathodic material with the electrolytic solution so as to form the composite cathode.

Abstract: The invention relates to systems and methods for observing materials, such as living cells or organisms, wherein the systems and methods utilize a microscopy system having an illumination source and an objective lens. A specimen including a predetermined amount of a liquid medium and a predetermined amount of an extracellular strongly absorbing dye is positioned for observation using the microscopy system. The illumination of the specimen correlates to the spectral region around the peak of the dye absorbance for the dye used in the system, such that live cells and organisms appear in contrast over a dark background for observation.

Abstract: A system and method for animated lip synchronization. The method includes: capturing speech input; parsing the speech input into phenomes; aligning the phonemes to the corresponding portions of the speech input; mapping the phonemes to visemes; synchronizing the visemes into viseme action units, the viseme action units comprising jaw and lip contributions for each of the phonemes; and outputting the viseme action units.

Abstract: An experimental setup for bridge deck large-amplitude vertical-torsional coupled free vibration in wind tunnel test, which belongs to the technical field of wind tunnel test apparatus. The experimental setup includes the rigid model, the rigid circular rods, the lightweight rigid circular sprockets, the chains, the linear tensile vertical springs, the bearings, the sliders, and the guides. For the new setup, large-amplitude vertical-torsional coupled free vibration of a rigid deck model that failed in conventional testing device can be adapted by the vertical deformation of the springs without any lateral tilt. As a result, the possible nonlinear mechanical stiffness due to the springs tilt in conventional testing device is excluded. In addition, owing to the low rolling friction and damping between the sprockets and the chains, the mechanical damping ratio of the system are quite low and stable for very large-amplitude vibrations.

Abstract: Provided is a semiconductor device with negative differential transconductance. The semiconductor device includes a substrate, a gate electrode formed on the substrate, an insulating layer formed on the gate electrode, a source electrode material layer formed on the insulating layer, a semiconductor material layer formed on the insulating layer to be hetero-joined to the source electrode material layer, a source electrode formed on the source electrode material layer, and a drain electrode formed on the semiconductor material layer. A work function of the source electrode material layer is controlled by a gate voltage applied through the gate electrode, and the source electrode material layer shows negative differential transconductance depending on a level of the gate voltage.

Abstract: Methods of protecting muscle tissue from heterotopic ossification employ targeted deliveries of a neuromuscular inhibitor. A method of protecting muscle tissue from heterotopic ossification includes identifying a volume of muscle tissue that is susceptible to heterotopic ossification. A first aliquot of a therapeutic dose of a neuromuscular inhibitor is delivered at a first delivery site within the volume of muscle tissue. A second aliquot of the therapeutic dose is delivered at a second delivery site within the volume of muscle tissue. The first and second delivery sites are separated by a distance to distribute the therapeutic dose within the targeted volume of muscle tissue.

Abstract: The present application discloses a single-point diamond dresser for a grinding wheel based on acoustic emission online monitoring, which includes a support module, an anti-interference module, a compression cooling module and an acoustic emission online monitoring module. An acoustic emission sensor monitors the dressing state of the grinding wheel online; a damping sheet and a damping interlayer greatly reduce external noise interference; a high pressure coolant causes an upward elastic deformation of an elastic spacer and the damping sheet, enlarging a contact force between the acoustic emission sensor and the core and moreover improving a sensitivity of the acoustic emission sensor; the coolant flows through the coolant passages in the core to cool a dressing area; current limiting passages, pressure relief cavities and perforated pressure-relief plates limit flow and reduce a pressure of the coolant, reducing the interference of the coolant on the grinding wheel dressing.

Abstract: Provided is a rice mitochondrial sterile gene and the application thereof. A rice mitochondrial sterile gene and a coding sequence thereof are disclosed. A specific molecular marker was designed from said gene sequence and enables a rapid and effective screening and identification of D1-type cytoplasm from wild rice for breeding a new D1-type cytoplasm sterile line. A specific sequence in the mitochondria genome of D1-type cytoplasm sterile line was identified by comparative genomics. Sterility-related ORFs were identified from gene prediction and expression difference analysis. A plant transformation vector was constructed to transform maintainer line for verification and sterile function.

Abstract: Described herein are hydrolyzed tetravalent salts and formulations thereof that can be used to inhibit a biofilm. Also described herein are uses of the hydrolyzed tetravalent salts and formulations thereof to inhibit a biofilm and/or treat biofilm infection.

Abstract: The present invention discloses a method and device of film stepless biaxial tension based on saddle-shaped surface transition.

Abstract: A wireless passive strain sensor is provided. The wireless passive strain sensor includes an outer coil holder, a reading inductance coil, a capacitance patch, an inner coil holder, and a sensing inductance coil. A shaft penetrates through the outer coil holder. The reading inductance coil is disposed on the outer coil holder. The capacitance patch is disposed on the shaft. The inner coil holder is disposed inside the outer coil holder. The inner coil holder is disposed on the shaft. The sensing inductance coil is disposed on the inner coil holder. The sensing inductance coil is electrically connected to the capacitance patch.