Patents Assigned to The University
  • Air-ground heterogeneous robot system path planning method based on neighborhood constraint
    Patent number: 10459437
    Abstract: The present invention relates to an air-ground heterogeneous robot system path planning method based on a neighborhood constraint. A smallest heterogeneous robot system is formed by a ground mobile robot and an air flying robot. The steps of the method include the ground mobile robot and the air flying robot start from a start point at the same time, successively access N sub-task points for executing sub-tasks and finally reach a destination together. In the present invention, it is considered that the position of each sub-task point is allowed to be effective in a certain neighborhood, and a neighborhood constraint is introduced. In addition, the maximum speed constraints are considered respectively for the air flying robot and the ground mobile robot.
    Type: Grant
    Filed: April 1, 2017
    Date of Patent: October 29, 2019
    Assignee: WUHAN UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Yang Chen, Yanping Tan, Huaiyu Wu, Lei Cheng, Minghao Jiang, Wen Long
  • Biomarker RNF6 for colorectal cancer
    Patent number: 10457993
    Abstract: The present invention provides a method for diagnosing of colorectal cancer in a subject and a method for determining risk of recurrence of colorectal cancer among colorectal cancer patients by detecting overexpression of the RNF6 gene, which in some cases is due to a higher than normal copy number of the genomic sequence of this gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating colon cancer by suppressing RNF6 gene expression or activity.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: October 29, 2019
    Assignee: The Chinese University of Hong Kong
    Inventors: Jun Yu, Joseph Jao Yiu Sung
  • Method and device for measuring a biological signal
    Patent number: 10456085
    Abstract: A method and device for measuring a biological variable are provided. The method of measuring the biological variable may include detecting an infrared signal which is irradiated toward a body part and is reflected therefrom, extracting spectrum data from the detected infrared signal, obtaining intensity data corresponding to a preset frequency from the extracted spectrum data, obtaining a biological information-measuring model by performing multiple linear regression (MLR) on the obtained data, and measuring a biological signal of the body part by using the obtained biological information-measuring model.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: October 29, 2019
    Assignees: SAMSUNG ELECTRONICS CO., LTD., IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)
    Inventors: Sangkyu Kim, Jungmok Bae, Joonhyung Lee, Hyeseon Lee, Hoeil Chung, Junghye Lee, Kyeol Chang, Seongho Cho
  • Nanoparticle delivery system for targeted anti-obesity treatment
    Patent number: 10456467
    Abstract: A magnetic nanoparticle including a TRPV1 agonist, as well as methods of preparation and use, are described herein. A magnetically responsive pharmaceutical can include a core region having a magnetic nanoparticle (MNPs) and a TRPV1 protein agonist. Further, an exterior coating comprising a polymer can be formed around the core region. The magnetically responsive pharmaceutical can be administered to a recipient and directed to a target region using an external magnetic field.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF WYOMING
    Inventors: Baskaran Thyagarajan, Padmamalini Baskaran
  • System and method for facilitating subterranean hydrocarbon extraction utilizing electrochemical reactions with metals
    Patent number: 10457853
    Abstract: Methods and systems for facilitating extraction of subterranean hydrocarbons from a geologic structure. The present methods include causing corrosion of a base metal within a geologic structure to produce a gaseous product to increase pressure and form fractures in the geologic structure. Some embodiments of the present methods include injecting a fluid composition comprising the base metal into a wellbore (e.g., into a geologic structure via the wellbore).
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: October 29, 2019
    Assignee: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
    Inventors: Cody Friesen, Jason Rugolo
  • Method for searching candidate material for anti-cancer drug using localized surface plasmon resonance
    Patent number: 10458911
    Abstract: A method for screening an anticancer candidate is disclosed. The method includes immobilizing gold nanoparticles onto a substrate; binding a protein involved in carcinogenesis and metastasis to the immobilized gold nanoparticles, recording a spectrum of the protein conjugate, and analyzing the spectrum to obtain reference data; adding a candidate inhibiting the activity of the protein to the protein conjugate, recording a spectrum of the mixture, and analyzing the spectrum to obtain comparative data; and comparing the reference data with the comparative data to determine whether the candidate inhibits the activity of the protein. The method enables screening of a candidate inhibiting the activity of a protein involved in carcinogenesis and metastasis in an accurate and convenient manner.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: October 29, 2019
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Sang Jun Sim, So Jin Song
  • System and method for reduced field of view MR fingerprinting for parametric mapping
    Patent number: 10459055
    Abstract: The present disclosure provides systems and methods for magnetic resonance fingerprinting (MRF). The method including steps comprising acquiring a plurality of MRF signals from a plurality of excitation volumes within a subject, wherein at least two of the plurality of excitation volumes differ in location within the subject, and wherein each of the excitation volumes partially overlap to form an overlap volume. The method also includes comparing the plurality of MRF signals acquired from the overlap volume with a dictionary of signal evolutions, determining one or more physical parameters of the overlap volume within the subject, and generating a report at least indicating the one or more physical parameters of the overlap volume within the subject.
    Type: Grant
    Filed: April 4, 2018
    Date of Patent: October 29, 2019
    Assignee: Case Western Reserve University
    Inventors: Mark A. Griswold, Yun Jiang
  • Torque-compensating assistive wrist braces
    Patent number: 10456286
    Abstract: In one embodiment, a torque-compensating assistive wrist brace includes a hand member adapted to be provided on a user's hand, a forearm member adapted to be provided on the user's forearm, and an assistive linkage that connects the hand and forearm members together and that applies a balancing torque to a wrist of the user that counteracts intrinsic stiffness within the wrist and assists the user in rotating the wrist in both the flexion and extension directions.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: October 29, 2019
    Assignee: The Regents of the University of California
    Inventors: Mark M. Plecnik, Derek Bissell, David Reinkensmeyer, J. Michael McCarthy
  • Method for desalination
    Patent number: 10457568
    Abstract: The invention discloses a method of removing dissolved elements from a liquid. The method comprises a first heating step for heating the liquid using a first heat source, a plurality of distillation steps for purifying the liquid heated by the first heating step, each of the plurality of distillation steps comprising at least one evaporation step and at least one condensation step, and a second heating step, using a second heat source to heat a plurality of flashing chambers, each generating a volume of vapor; wherein the vapor from at least one of the plurality of flashing chambers of the second heating step is introduced into at least one of the plurality of distillation steps.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: October 29, 2019
    Assignee: MURDOCH UNIVERSITY, National Centre of Excellence in Desalination Australia
    Inventors: Bijan Rahimi, Hui Tong Chua, Alexander Christ
  • Therapeutic DNP derivatives and methods using same
    Patent number: 10457629
    Abstract: The present invention includes DNP derivatives of formula (I) that are useful for preventing or treating a metabolic disease or disorder in a subject in need thereof. In certain embodiments, the subject is further administered at least one additional therapeutic agent.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: October 29, 2019
    Assignee: Yale University
    Inventors: Gerald I. Shulman, David A. Spiegel
  • Metamaterials for surfaces and waveguides
    Patent number: 10461433
    Abstract: Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may include Babinet complements of “split ring resonator” (SRR) and “electric LC” (ELC) metamaterial elements. In some approaches, the complementary metamaterial elements are embedded in the bounding surfaces of planar waveguides, e.g. to implement waveguide based gradient index lenses for beam steering/focusing devices, antenna array feed structures, etc.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: October 29, 2019
    Assignee: Duke University
    Inventors: David R. Smith, Ruopeng Liu, Tie Jun Cui, Qiang Cheng, Jonah N. Gollub
  • Pipe evaluation method, measurement device, and pipe evaluation system
    Patent number: 10458881
    Abstract: This internal pressure loading system includes an internal pressure loading device and an information processing device. The internal pressure loading device is set at an inner face of a pipe, and includes a load meter which detects the load applied to the inner face of the pipe and a displacement meter which detects the deformation amount of the pipe. When the internal pressure loading device is expanded so as to increase the load to be detected by the load meter, the width of the pipe at which the displacement meter is located is reduced. On the basis of the load detected by the load meter and the deformation amount detected by the displacement meter, the information processing device evaluates the remaining strength of the pipe.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: October 29, 2019
    Assignees: NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY, NATIONAL UNIVERSITY CORPORATION SHIMANE UNIVERSITY
    Inventors: Masahiro Hyodo, Hidehiko Ogata, Naoki Kawamura, Tsuguhiro Nonaka, Masayuki Ishii
  • Sphingosine kinase type 1 inhibitors and uses thereof
    Patent number: 10456370
    Abstract: Provided are inhibitors of sphingosine kinase Type I and their use in the treatment of asthma, among other indications and diseases.
    Type: Grant
    Filed: November 26, 2018
    Date of Patent: October 29, 2019
    Assignees: Enzo Therapeutics, Inc., Virginia Commonwealth University
    Inventors: Sarah Spiegel, Robert Elliot Zipkin, Jeffrey Kroll Adams
  • Chimeric proteins and methods of regulating gene expression
    Patent number: 10457961
    Abstract: The present disclosure provides systems, compositions and methods for regulating expression of a target polynucleotide in a cell. The systems, compositions and methods comprise a chimeric receptor polypeptide comprising a G-protein coupled receptor (GPCR) or a fragment thereof, a chimeric adaptor polypeptide, at least one actuator moiety and a cleavage moiety.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: October 29, 2019
    Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
    Inventors: Lei S. Qi, P. C. Dave P. Dingal
  • High performance membranes for water reclamation using polymeric and nanomaterials
    Patent number: 10456754
    Abstract: A water permeable membrane for water purifications applications including filtration, ultrafiltration, nanofiltration and reverse osmosis is provided. The water permeable membrane includes a porous support and a composite layer disposed over the porous support. Characteristically, the composite layer includes graphene oxide dispersed within a polymer matrix.
    Type: Grant
    Filed: August 10, 2015
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Thieo Hogen-Esch, Massoud Pirbazari, Varadarajan Ravindran, Hayriye Merve Yurdacan, Woonhoe Kim
  • Oncolytic herpes simplex virus and therapeutic uses thereof
    Patent number: 10456432
    Abstract: The present invention relates to variants of herpes simplex virus (HSV) that selectively infect and replicate in cancer cells, including HSV strains that selectively infect and replicate in bladder cancer cells. Preferred HSV of the invention have intact endogenous Us11 and Us12 genes and have genes encoding ICP34.5 replaced with a gene encoding Us11 fused to an HSV immediate early (IE) promoter. The variant HSV of the invention also comprise one or more additional heterologous genes encoding immunomodulatory polypeptides. Methods and compositions using these variant HSV, for example, for treating cancer in a subject, are also provided.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: October 29, 2019
    Assignees: New York University, BeneVir Biopharm, Inc.
    Inventors: Ian J. Mohr, Matthew C. Mulvey
  • Platinum prodrugs and methods of making and using thereof
    Patent number: 10457700
    Abstract: Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: October 29, 2019
    Assignee: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
    Inventors: Shanta Dhar, Rakesh Pathak
  • System and method for inducing somatic sense using air plasma and interface device using them
    Patent number: 10459522
    Abstract: A system and method for generating air plasma by radiating a laser in the air, and making a user feel a somatic sense such as a tactile sense, a thermal sense or the like using a principle of inducing a state change in a medium as a result of a shock wave or an electric field generated by the air plasma.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: October 29, 2019
    Assignee: KONKUK UNIVERSITY GLOCAL INDUSTRY-ACADEMIC COLLABORATION FOUNDATION
    Inventors: Soon-Cheol Chung, Hyung-Sik Kim, Jae-Hoon Jun
  • Substituted amides for treating and preventing cancer
    Patent number: 10457662
    Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure (e.g., a compound having Formula I: which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic cancer).
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: October 29, 2019
    Assignees: The Regents of the University of Michigan, The Board of Regents of the University of Texas System
    Inventors: Nouri Neamati, Jia Zhou, Yuting Kuang, Na Ye
  • Impedance compensation structure for broadband near-field magnetic-field probe and its construction method
    Patent number: 10461386
    Abstract: An impedance compensation structure for a broadband near-field magnetic-field probe, includes: a signal via; and a plurality of grounding vias provided around the signal via to form a coaxial via array; wherein the grounding via and the signal via have an identical size, all distances of each of the plurality of the grounding vias to the signal via are equal, and the plurality of the grounding vias forms a circle centered at the signal via; wherein each of the plurality of the grounding vias is connected with a magnetic field probe top layer shield plane and a magnetic field probe bottom layer shield plane; each of the plurality of the grounding vias keeps in a conducting state from a direct current to a high frequency, in such a manner that impedance matching of the broadband near-field magnetic-field probe is achieved.
    Type: Grant
    Filed: April 8, 2017
    Date of Patent: October 29, 2019
    Assignee: BEIHANG UNIVERSITY
    Inventors: Zhaowen Yan, Jianwei Wang, Wei Zhang, Donglin Su