Abstract: The present embodiments include methods of time-frequency analyzing signals. Some embodiments provide methods of processing signals comprising: adaptively partitioning at least a portion of a signal in a time domain into a plurality of segments of the signal; and transforming each of the segments of the signal producing respective expansions in a frequency domain and obtaining respective samples of the windows of signal in the frequency domain.

Abstract: The present invention relates to compositions comprising EbpA and methods of use thereof. Specifically, methods useful in the treatment and prevention of EbpA-associated infections.

Abstract: This document relates to materials and methods for treating cancer (e.g., prostate cancer). For example, methods for using one or more androgen receptor variant (AR-V) inhibitors (e.g., morpholinos) to treat a mammal having prostate cancer (e.g., castration-resistant prostate cancer) are provided.

Abstract: Many electrodes are positioned inside a skull for obtaining several electric voltage variation wave information. A processing unit computes subtract operation between two neighboring electrical voltage variation wave information respectively and then can obtain electrical voltage difference waves. Furthermore, each electrical voltage difference wave is separated into a first band wave signal and a second band wave signal. After which, several first band wave envelope signals and second band wave envelope signals are obtained. It conducts a co-relation processing about the first band wave envelope signals and the second band wave envelope signals. So, a co-relation table is obtained for determining a position where an intracranial brain wave abnormality occurs. In this invention, a unique scientific approach to determine the spatial position of seizure onset occurred inside the brain. In addition, the position of intracranial brain wave abnormality can be concretized and visualized by the co-relation table.

Abstract: Provided is a signal detection method of a staggered two-dimensional bit-patterned media and a recording medium and an apparatus for performing the method.

Abstract: The method for producing a cellulose-containing solid material of the invention includes treating a botanical biomass in a mixed solvent of water and at least one alcohol selected from aliphatic alcohols having 4 to 8 carbon atoms, under condition A (the concentration of the raw material to be charged into the mixed solvent is 1% by mass or more and 50% by mass or less), condition B (the reaction temperature is 100° C. or higher and 350° C. or lower), and condition C (the reaction time is 0.1 hours or more and 10 hours or less), followed by solid-liquid separation after the treatment to give a cellulose-containing solid material. Accordingly, there are provided a method for producing a cellulose-containing solid material excellent in saccharification performance and a method for producing glucose from the cellulose-containing solid material.

Abstract: Recombinant high affinity Invasin polypeptide are provided herein. Further provided are methods of delivering therapeutics such as vaccines by conjugation to the engineered recombinant Invasin polypeptides.

Abstract: A zero-strain soil pressure sensor includes a shell provided with a hydraulic oil cavity and a cavity located below the hydraulic oil cavity, a processor, an outer elastic film arranged at the upper end of the hydraulic oil cavity, an inner elastic film arranged between the hydraulic oil cavity and the cavity, an outer strain bridge circuit connected with the outer elastic film, an inner strain bridge circuit connected with the inner elastic film, a piston communicated with the hydraulic oil cavity, and a driving mechanism connected with the piston. The outer strain bridge circuit, the inner strain bridge circuit and the driving mechanism are electrically connected with the processor.

Abstract: There is provided a computer-implemented method for detecting and measuring stomata present in the epidermis of a plant leaf, the method comprising obtaining an image of the epidermis of a plant leaf; detecting valid stomata candidates within the image; determining physical dimensions of the valid stomata candidates; and determining vital functions of the plant based on the physical dimensions of the valid stomata candidates. There is also provided a computing device capable of measuring leaf stomata.

Abstract: Regulated changes in gene expression underlie many biological processes, but globally profiling cell-to-cell variations in transcriptional regulation is problematic when measuring single cells. Transcriptome-wide identification of regulatory heterogeneities can be robustly achieved by randomly collecting small numbers of cells followed by statistical analysis. However, this stochastic-profiling approach blurs out the expression states of the individual cells in each pooled sample. Various aspects of the disclosure show that the underlying distribution of single-cell regulatory states can be deconvolved from stochastic-profiling data through maximum-likelihood inference. Guided by the mechanisms of transcriptional regulation, the disclosure provides mixture models for cell-to-cell regulatory heterogeneity which result in likelihood functions to infer model parameters.

Abstract: A method of fabricating a thin film transistor includes preparing a plastic substrate, forming a transparent active layer on the plastic substrate through an atomic layer deposition method by providing a first source including zinc on the plastic substrate and providing a second source including sulfur on the plastic substrate, providing a gate electrode overlapping with the transparent active layer, and providing a gate insulating layer between the gate electrode and the transparent active layer. A ratio of the providing of the first source to the providing of the second source ranges from 7:1 to 13:1.

Abstract: A buffer composition for hybridization of a target nucleic acid is provided. The nucleic acid can include a nucleotide to be detected with a nucleic acid probe. The probe can contain a nucleotide sequence complementary to the target nucleic acid. The buffer can include a blocking nucleic acid having a nucleotide sequence complementary to a non-target nucleic acid having a nucleotide not to be detected corresponding to the nucleotide to be detected. The buffer composition can suppress non-specific hybridization to the nucleic acid probe even when a non-target nucleic acid is present. The use of the buffer composition can achieve excellent detection efficiency of the target nucleic acid.

Abstract: Provided are transporters based on polymyxin B. Also provided are methods of using the transporters for intracellular delivery of cargo and methods of enhancing intracellular uptake of cargo.

Abstract: The present invention provides a memory device in which a lower electrode, a seed layer, synthetic antiferromagnetic (SyAF) layers, a separation layer, a magnetic tunnel junction, a capping layer, and an upper electrode are formed on a substrate in a laminated manner, wherein a diffusion barrier is formed between the magnetic tunnel junction and the capping layer. In addition, the present invention provides a memory device in which a lower electrode, a seed layer, SyAF layers, a separation layer, a magnetic tunnel junction, a capping layer, and an upper electrode are formed on a substrate in a laminated manner, wherein the seed layer is formed of a material that allows the SyAF layers to grow in the FCC (111) direction.

Abstract: There is provided an ultra-light decoder for high speed digital communications based on block codes such as turbo product codes (TPCs). The new decoder can perform soft decision decoding without an algebraic hard decision decoder, which is the core of conventional soft decision decoders. The elimination of algebraic decoder significantly reduces the number of computations required per codeword, consequently, it reduces the decoding delay and processing power. However, reducing the decoding delay would immediately enable increasing the transmission speed, and minimize the need for large buffers at the receiver. Moreover, reducing the complexity and delay would enable using codes with high code rates to increase the system capacity, or use powerful codes with low code rates to reduce the transmission power. Such benefits can be achieved for about 1 dB loss in coding gain. There is also provided a receiver comprising the ultra-light decoder, as well as a decoding process.

Abstract: The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of antibiotic resistant skin infections. In other embodiments, the compositions direct delivery within the skin. In still other embodiments, the compositions prevent transfer of substances through the stratum corneum. The disclosed compositions and methods can be tuned and modified such that they can be used to treat or prevent a variety of different diseases and disorders.

Abstract: An object of the present invention is to provide a method for producing conductive mayenite, with which a reaction is completed in a short time, an operation can be simplified, the reaction is easily controlled, and the cost of energy can be reduced. The present invention is a method for producing conductive mayenite, characterized by mixing a mayenite type compound with a carbon component, placing the resulting mixture in an airtight container, and irradiating the mixture with a microwave in an inert gas atmosphere or in a vacuum atmosphere to heat the mixture.

Abstract: Systems and methods for clinical neuronavigation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for generating a brain stimulation target, including obtaining functional magnetic resonance imaging (fMRI) image data of a patient's brain, were brain imaging data describes neuronal activations within the patient's brain, determining a brain stimulation target by mapping at least one region of interest to the patient's brain, locating functional subregions within the at least one region of interest based on the fMRI image data, determining functional relationships between at least two brain regions of interest, generating parameters for each functional subregion, generating a target quality score for each functional subregion based on the parameters and selecting a brain stimulation target based on its target quality score and the patient's neurological condition.

Abstract: A simple one pot sol-gel method for the synthesis of bi-metal nanostructures is based on non-noble metals (Fe, Co and Sn) and titanium. The method involves the synthesis of mixed metal nanoscale composites using low cost precursors which allow for the synthesis of desired nanocomposite materials with self-scarifying titanium or silica supports. The procedure does not require any surfactant or any need for pH controlled step. Applicants' method involves the in-situ generation of precursors and their simultaneous entrapment in a gel. This simple one pot synthesis allows for the synthesis of homogenous size, shape and distribution of targeted nanostructures. Further, this method can be applied for the preparation of various nanocomposite materials using different choices of metals and self-scarifying supports. Applicants also show that Pd, the noble metal based nanocomposite is feasible.

Abstract: A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (BBMI) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the BBMI in a human. The bi-directional devices (BBMIs) communicate with other bi-directional brain-machine interface devices (BBMI) and/or with external controllers wirelessly. The compact implantable stimulator has ultrasonic secondary battery charging system. One or more BBMI can be wirelessly connected so that a closed loop of BBMIs, or a BBMI and an external controller, can wirelessly send trigger pulses to this fully implanted stimulator over the spinal cord.