Abstract: Disclosed is a fluorescence microscope for imaging a specimen a fluorescent substance, the fluorescence microscope including an excitation light source configured to emit an excitation light that excites a fluorescent substance to emit fluorescence; a de-excitation light source configured to emit a de-excitation light that de-excites the fluorescent substance excited by the excitation light emitted from the excitation light source; an optical body configured to overlap a light emitted from the excitation light source and a light emitted from the de-excitation light source, and to discharge the overlapped light toward the specimen; and a solid immersion lens to which the light discharged from the optical body is incident, and configured to refract the light discharged from the optical body toward the specimen. A total reflection of the light incident to the solid immersion lens occurs on a bottom of the solid immersion lens.

Abstract: A system for three dimensional imaging of an object contained within a sample includes an image sensor, a sample holder configured to hold the sample, the sample holder disposed adjacent to the image sensor, and an illumination source comprising partially coherent light. The illumination source is configured to illuminate the sample through at least one of an aperture, fiber-optic cable, or optical waveguide interposed between the illumination source and the sample holder, wherein the illumination source is configured to illuminate the sample through a plurality of different angles.

Abstract: An adaptively positioned mitral valve closure plate blocker for repairing mitral regurgitation, comprising a suture and shaping ring (4.1) sutured on a mitral ring (2.1) and a closure plate (4.2); the closing plate (4.2) comprises a tongue-shaped plate and a strut (4.3) located at the top of the tongue-shaped plate and connected to the suture and shaping ring; the closing plate (4.2) can be connected to the suture and shaping ring (4.1), being capable of flapping back and forth and twisting left and right. The suture and shaping ring is sutured on the valve ring (2.1) of the mitral valve (2) of a patient in a thoracotomy and open heart surgery, thus shaping the disease expanded mitral ring (2.1), and supporting the closing plate (4.2); when a heart contracts and valve leaflets close, the closing plate (4.2) flaps and twists depending on the position of a regurgitation opening at the free edge of the valve leaflets to realize adaptive positioning of the closing plate (4.2), so that the closing plate (4.

Abstract: The present invention relates to a method of differentiating mesenchymal stem cells or adult stem cells into nerve cells by treating the mesenchymal stem cells or the adult stem cells with an electromagnetic field having a high intensity of 100 to 1,500 mT and a low frequency of 0.01 to 100 Hz. The present invention also relates to a medical device to which the method is applied. The method of differentiating nerve cells by using a magnetic field, and a composition according to the present invention induce the differentiation of adult stem cells into nerve cells by using a low-frequency, high-intensity electromagnetic field, so that nerve cells or neural stem cells can easily be differentiated through only electromagnetic field treatment in a short time.

Abstract: The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, ?3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle ?-actin, nestin, hepatocyte growth factor, stromal derived factor-1? and Hlx homeobox transcriptional factor.

Abstract: The present invention provides substituted benzimidazoles, pharmaceutical composition comprising the substituted benzimidazoles, and their use for preventing or treating a subject suffering from diseases or conditions associated with platelet activation aggregation and/or platelet activation.

Abstract: A phase converting device capable of use over a broad wavelength range, which may be used for optical beam transformations and combining, conversion of resonator and waveguide modes, correction of aberrations in optical systems, and selection of photons with specific phase profile. This provides significant advantages in high power laser systems. Large-mode-area fibers can be used to provide higher incident powers than can be achieved by single-mode fibers, reducing the number of elements in a system necessary to achieve the desired output. The profiles of these LMA fiber modes can then be converted from the undesired modes into the desired mode while combing their total power into a single beam.

Abstract: Plasma which is supplied from a supply passage (1) is accelerated with a Hall electric field (E) which is generated through interaction of electrons (e?) emitted from a cathode (3), a radial direction magnetic field (Bd), and an electric field (Ex).

Abstract: Provided is a method for treatment and/or prophylaxis of a condition associated with T cell mediated chronic inflammatory disease by administration, to a patient, of a peptide comprising N?-SVTEQGAELSNEER-C? (SEQ ID NO: 1) or an analogue thereof that inhibits T cell migration. Also provided is the peptide or its analogue for use in the methods of treatment and/or prophylaxis of said condition. Also provided is a method for the treatment of Sjogren's syndrome by administration of a peptide comprising N?-SVTEQGAELSNEER-C? to a patient in need thereof.

Abstract: Disclosed is an optical fiber including a plasmonic optical filter with a closed curved shape provided at, at least portion thereof. A method of manufacturing the plasmonic optical filter includes a step of exposing a core, a step of forming a thin metal film on the core through physical vapor deposition while rotating the core in a circumferential direction after changing a rotation axis of the core, and a step of patterning nanopatterns on the cylinder-shaped thin metal film using focused ion beam technique assisted with endpoint detection method. Due to such constitutions, an active area to generate an optical signal for optical sensor can be increased.

Abstract: A method for decoding an image, according to the present invention, can comprise the steps of: drawing out a vector predictor of a block vector for indicating a reference block with respect to a current block to be predicted within a current picture; drawing out the block vector on the basis of the vector predictor and a vector differential value corresponding to a different value of the block vector and the vector predictor; and generating a prediction block with respect to the current block on the basis of the block vector.

Abstract: A method of treating and/or preventing Dravet Syndrome in a patient such as a patient previously diagnosed with Dravet Syndrome, by administering an effective dose of fenfluramine or its pharmaceutically acceptable salt to that patient. Dravet Syndrome patients are typically children under the age of 18 and are treated at a preferred dose of less than about 0.5 to about 0.01 mg/kg/day.

Abstract: A photo-tunable liquid crystal composition may include a polymer matrix and a liquid crystal mixture dispersed within the polymer matrix. The liquid crystal mixture may include at least one achiral nematic liquid crystal material, at least sine photo-active chiral dopant, at least one photo-inactive chiral dopant, and at least one emissive dye. The composition may be fabricated in the form of an emulsion, a wet film, or a dry film. The dry film may be used in a photo-tunable liquid crystal film laser. The output wavelength of the photo-tunable liquid crystal film laser may be tuned by exposing the dry film to illumination having at least one wavelength at one or more transition wavelengths.

Abstract: Disclosed herein is a data evaluation device using similarity for searching a plurality of documents for a document similar or substantially identical to a given document, a method therefor, and a computer-readable recording medium with the method recorded thereon. The data evaluation device using similarity includes an input unit receiving first and second records, a record set generating unit arraying the first and second records in alphabetical order and giving one token to each arrayed word to generate corresponding first and second record sets, and a similarity verifying unit determining that the first and second records are not similar when a position at which a comparison token in the first record set, which is allocated to a word identical to a median value token disposed at a position corresponding to a median value in the second record set, is in a preset range.

Abstract: A 3D printing system may print a desired 3D object. A fusible powder may fuse when subjected to a fusing condition. A deposition system may deposit portions of the fusible powder on a substrate. A fusing system may apply the fusing condition to the deposited fusible powder. Inhibitor material may not fuse when subjected to the fusing condition. An insertion system may insert a portion of the inhibitor material between portions of the deposited fusible powder after having been deposited by the deposition system, but before being fused by the fusing system, so as to form a boundary that defines at least a portion of a surface of the desired 3D object.

Abstract: Local swing leg control was developed that takes advantage of segment interactions to achieve robust leg placement under large disturbances while generating trajectories and joint torque patterns similar to those observed in human walking and running. The results suggest the identified control as a powerful alternative to existing swing leg controls in humanoid and rehabilitation robotics. Alternatively, a detailed neuromuscular model of the human swing leg was developed to embody the control with local muscle reflexes. The resulting reflex control robustly places the swing leg into a wide range of landing points observed in human walking and running, and it generates similar patterns of joint torques and muscle activations. The results suggest an alternative to existing swing leg controls in humanoid and rehabilitation robotics which does not require central processing.

Abstract: The invention relates to methods and compositions for regulation of GSK3? activity. The invention provides phosphorylated GSK3? polypeptides and antibodies that recognize such polypeptides The invention further includes methods for treating disorders that are associated with elevated or reduced GSK3? activity.

Abstract: Administration of isoleucine, leucine and valine is effective for the prophylaxis and/or therapy of idiopathic inflammatory myopathy or idiopathic inflammatory myopathy associated with steroid-induced myopathy that develops during the course of treatment. This method is effective for the prophylaxis and/or therapy of idiopathic inflammatory myopathy or idiopathic inflammatory myopathy associated with steroid-induced myopathy that develops during the course of treatment.

Abstract: Recombinant, chimeric porcine influenza viruses are disclosed that include hemagglutinin segments from more than one influenza virus subtype. Also described are methods of producing the recombinant influenza viruses, immunogenic compositions comprising the recombinant influenza viruses, methods of stimulating an immune response against influenza virus, and methods of treating and preventing influenza virus infection.

Abstract: A carrier gas is directed through a humidification chamber in a humidifier, where the carrier gas flow is directly contacted with a feed liquid to humidify the carrier gas with water evaporated from the feed liquid, producing a humidified gas flow. The humidified gas flow is then compressed in a compressor and then directed through a dehumidification chamber in a dehumidifier, where the compressed humidified gas flow is dehumidified to condense water from the compressed humidified gas flow. The dehumidified gas flow is then expanded in an expander, wherein the expansion of the dehumidified gas flow generates motion (e.g., rotation of a shaft), and wherein the motion generated in the expander is transferred to the compressor, where the motion compresses the humidified gas flow. Heat is also removed from the expanded dehumidified gas flow and transferred to compressed dehumidified gas flow upstream from the expander.