Abstract: The present disclosure provides targeted drug delivery vehicle compositions comprising a drug composition and targeted poly-amino-acid subunits, methods of manufacture, and methods of treatment for numerous diseases.

Abstract: In one aspect, optoelectronic devices are described herein. In some embodiments, an optoelectronic device described herein includes a radiation transmissive first electrode, a second electrode, a light emitting organic layer disposed between the first electrode and the second electrode, a dielectric layer disposed between the light emitting organic layer and the first electrode and/or second electrode, and a phosphor layer disposed in an optical path of the light emitting organic layer, wherein the light emitting organic layer includes a singlet emitter phase and a triplet emitter phase.

Abstract: An apparatus for achieving a cryogenic temperature in a movable system, includes a rotating table, a vacuum chamber which is fixed on the rotating table, a cryogen-free refrigerator which has a cooling section inside the vacuum chamber, an inner cylinder which is fixed to a bottom of the rotating table, an outer cylinder which stores the inner cylinder such that the inner cylinder is rotatable and includes an outward and return gas port which is provided to be continuous with gas passages, a compressor which circulates gas to the cryogen-free refrigerator through the outward and return gas passages, and a rotary joint for wiring which is fixed to the inner cylinder and rotatably conducts electricity, wherein a piece of internal wiring is led through a through-hole and a hole, and electricity is supplied to a piece of equipment on the rotating table through the piece of internal wiring.

Abstract: One or more graphene layers may be formed on a diamond substrate by reforming sp3 hybrid orbitals of C—C bonds in a portion of the diamond substrate into sp2 hybrid orbitals. Forming sp2 hybrid orbitals may be achieved by ion bombardment to damage the sp3 hybrid orbitals of the C—C bonds in the diamond substrate and subsequent heating of the diamond substrate to allow annealing to take place. If more than ten graphene layers are formed on the diamond substrate, the graphene layers may be reduced to ten or less graphene layers. Removal of the graphene layers may be performed by peeling a desired number of layers using an adhesive material.

Abstract: A system, method and apparatus tracks targets (e.g., tumors) during treatment (e.g., radiation therapy) using a radar motion sensor by generating a microwave signal, radiating the microwave signal to a subject, and receiving a modulated microwave signal from the subject. The modulated microwave signal is processed to provide a subject motion information using a sensor having an arctangent-demodulation microwave interferometry mode. A location of a target on or within the subject is determined based on the subject motion information and a three-dimensional model for the subject and the target. One or more control signals are generated based on the location of the target, and the treatment device is controlled using the one or more control signals to treat the target on or within the subject.

Abstract: A superhydrophobic surface includes a plurality of microfeatures disposed on a substrate and a gas generator disposed within the microfeatures, the gas generator configured to generate a gas within the microfeatures. Gas is generated within the microfeatures when at least a portion of the microfeatures is in a wetted state to restore the microfeatures to a dewetted state. Gas generation is self-regulating in that gas generation automatically starts when a wetted condition exists and stops when sufficient gas has been generated to recover a dewetted state that restores superhydrophobicity.

Abstract: A biosensor that is capable of detecting the presence and/or concentration of an analyte or biomarker includes at least one electrically conductive electrode operatively coupled to an impedance analyzer for measuring the change in the resistive impedance ?ZRe of the electrode in response to an applied alternating current at a plurality of frequencies. In one embodiment, at least one electrode is covered with a self-assembled monolayer that is chemically bonded to a surface. A plurality of virus particles such as phage viruses are immobilized on the self-assembled monolayer and may be exposed to a test or sample solution. The virus particles may be obtained from phage-displayed libraries to detect a wide variety of targets including, for example, DNA, RNA, small molecules, and proteins or polypeptides. In another embodiment, the virus particles are electrostatically bound to a substrate in between a pair of elongated electrodes disposed on a substrate.

Abstract: Provided are a novel diabody type bispecific antibody, the function of which as a bispecific antibody is improved to provide a higher additional value, such as cost saving caused by a reduction in dose, to a drug; and a method for producing the same. A humanized diabody type bispecific antibody (LH-diabody type bispecific antibody) characterized in that an L-chain is located in the N-terminal side in each polypeptide (LH type); a humanized high-functional bispecific antibody which contains said LH diabody type bispecific antibody; a nucleic acid molecule encoding both of two kinds of single-stranded polypeptides constituting said bispecific antibody; and a method for producing said antibody which comprises culturing a host cell having been transformed by an expression vector containing said nucleic acid molecule.

Abstract: Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds.

Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer or member having an unexpanded configuration and an expanded configuration, wherein the expandable member in an expanded configuration has a size, volume and/or shape configured for positioning between the spinous processes of adjacent vertebrae in order to distract the vertebrae relative to each other. The systems include one or more expandable members and a mechanical actuation means for expanding the expandable member. The methods involve the implantation of one or more devices or expandable spacers.

Abstract: The invention provides methods for muscle repair or regeneration comprising administering therapeutically effective amounts of RAR agonists or stem cells that are pretreated with contact with a RAR agonist to a subject at a site of muscle damage. Additionally, the invention provides compositions comprising RAR agonist treated stem cells and methods of use of said cells for muscle repair or regeneration. In one embodiment, the stem cells are mesenchymal stem cells. In one embodiment, the RAR agonist is an RAR? agonist. In one embodiment, administration of the RAR agonist is begun during a period of increased endogenous retinoid signaling in the subject resulting from incurrence of the damaged muscle tissue.

Abstract: A passive and reusable preconcentrator/injector device for measuring gas-phase analytes and methods of use. The device includes an upper plate defining an array of micro-scale diffusion channels and a lower plate secured to the upper plate. The lower plate defines a cavity for a reusable collection material in fluid communication with the micro-scale diffusion channels. An integral heating unit is provided adjacent the lower plate and configured for heating the cavity. A loading port may be included for introducing the reusable collection material into the cavity. An inlet port and an outlet port are provided, both in fluid communication with the cavity. The device may include a fluidic manifold system comprising a plurality of conduits disposed between the adsorbent cavity and the outlet port.

Abstract: Described herein are fatty acid carbohydrate hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.

Abstract: Provided is a method and apparatus for low power operation of a binaural hearing aid, the method including determining whether a residual battery exceeds a predetermined threshold level, collecting an external audio signal, in response to whether the residual battery exceeds the predetermined threshold level, and transmitting the collected audio signal to a second hearing aid.

Abstract: The present disclosure provides a three-dimensional (3-D) transformer-based (TF-based) power amplifier architecture, including a power splitting plane having at least one input transformer-based circuit; and a power combining plane having at least one output transformer-based circuit. The power splitting plane includes at least one input transmission line, at least one input transformer and an input terminal. Moreover, the power combining plane includes at least one output transmission line, at least one output transformer, at least one power amplifier-cell (PA-cell) and an output terminal. The power combining plane is vertically stacked, attached and electrically connected to the power splitting plane. Consequently, as compared with the existing 2-D power amplifiers, the 3-D transformer-based power amplifier architecture of the present disclosure is capable of achieving a symmetric and compact power distribution layout.

Abstract: The invention relates to a novel use of the members of the IL-10 cytokine family in wound healing. Particularly, the invention relates to the use of the member of the IL-10 cytokine family in the promotion of the proliferation and the migration of keratinocyte cells in wound healing.

Abstract: A computer-based system and method(s) are described which detects and identifies implanted medical devices (“IMDs”) and/or retained surgical foreign objects (“RSFOs”) from diagnostic medical images. In some embodiments, the system provides further identification—information on the particular IMD and/or RSFO that has been recognized. For example, the system could be configured to provide information feedback regarding the IMD, such as detailed manual information, safety alerts, recalls, assess its' structural integrity, and/or suggested courses of action in a specific clinical setting/troubleshooting. Embodiments are contemplated in which the system is configured to report possible 3D locations of RSFOs in the surgical field/images.

Abstract: A leadpipe for a musical instrument comprising: a sidewall defining an enclosed channel, the sidewall having an upstream end and a downstream end; wherein the sidewall is comprised of a plurality of sections including a first tapered section and at least one subsequent tapered section; wherein each of the sections extends longitudinally between the upstream end and the downstream end of the sidewall; wherein the first tapered section is disposed upstream of the at least one subsequent tapered sections; wherein the first tapered section and at least one subsequent tapered section of the sidewall each define a generally frustoconical cavity having an upstream inner diameter Df and a downstream inner diameter Ds; and wherein the downstream diameter of each of the tapered sections that defines a generally frustoconical cavity is larger than the upstream diameter. The leadpipe may produce greater intensity of overtones and improved sound quality.

Abstract: The present invention provides a series of DC-DC converter circuit designs, and DC-DC converters based on such circuit design, that provide high input-to-output voltage conversion. The converters include a resonant tank and a means for interrupting the tank current to produce a near zero-loss “hold” state wherein zero current and/or zero voltage switching is provided, while providing control over the amount of power transfer. A resonant DC-DC converter for high voltage step-up ratio in accordance with the circuit design includes: (a) a low voltage DC-AC converter, (b) a resonant tank, (c) a high voltage AC-DC converter, (d) a (i) common ground on an input and an output without use of a transformer and/or (ii) a single high voltage controllable switch within the resonant tank.

Abstract: A human image detection and tracking systems and methods are disclosed. A human image detection method comprises receiving a depth image data from a depth image sensor by an image processing unit, removing a background image of the depth image sensor and outputting a foreground image by the image processing unit, receiving the foreground image and operating a graph-based segment on the foreground image to obtain a plurality of graph blocks by a human image detection unit, determining whether a potential human region exists in the graph blocks, determining whether the potential human region is a potential human head region, determining whether the potential human head region is a real human head region, and regarding the position of the real human head region is the human image position by the human image detection unit if the potential human head region is the real human head region.