Patents Assigned to The University
  • METHODS AND COMPOSITIONS FOR TREATMENT OF POLYCYSTIC KIDNEY DISEASE
    Publication number: 20220380767
    Abstract: Provided herein are methods for the treatment of polycystic kidney disease, including autosomal dominant polycystic kidney disease, using modified oligonucleotides targeted to miR-17.
    Type: Application
    Filed: July 22, 2022
    Publication date: December 1, 2022
    Applicants: Regulus Therapeutics Inc., The Board of Regents of The University of Texas System
    Inventors: Charles R. ALLERSON, Vishal D. PATEL, B. Nelson CHAU, John R. ANDROSAVICH
  • Methods and Kits using Internal Standards to Control for Complexity of Next Generation Sequencing(NGS) Libraries
    Publication number: 20220380841
    Abstract: Described herein are kits and methods for quantifying the amount of at least one nucleic acid of interest in a sample. The kits include a mixture of synthetic spike-in internal standards (IS) reagents, where the spike-in IS reagents comprise a complexity calibration ladder (CCL) that includes synthetic internal standard competitors for at least one target gene.
    Type: Application
    Filed: November 13, 2020
    Publication date: December 1, 2022
    Applicant: The University of Toledo
    Inventors: James C. Willey, Erin L. Crawford
  • T CELLS EXPRESSING MEMBRANE-ANCHORED IL-12 FOR THE TREATMENT OF CANCER
    Publication number: 20220380429
    Abstract: Provided herein are polypeptides comprising membrane-anchored IL-12. Also provided herein are T cells expressing the membrane-anchored IL-12. Further, methods of treating cancer comprising administering T cells expressing membrane-anchored IL-12 are provided herein. Also provided are combination treatments comprising T cells expressing membrane-anchored IL-12 and T cell chemoattractant-inducing chemokines. In addition, methods are provided for activating T cells to express NKG2D and methods of their use in the treatment of cancer.
    Type: Application
    Filed: July 21, 2022
    Publication date: December 1, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Shulin LI, Jiemiao HU, Xueqing XIA
  • BIODEGRADABLE ULTRA-PH SENSITIVE POLYMERS
    Publication number: 20220380534
    Abstract: The present disclosure relates to degradable polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and have backbones which are capable of undergoing degradation in vivo. In some aspects, the disclosure also provides methods of using these degradable polymers for the delivery of a drug.
    Type: Application
    Filed: June 22, 2020
    Publication date: December 1, 2022
    Applicant: The Board of Regents of The University of Texas System
    Inventors: Jinming GAO, Xu WANG, Houliang TANG, Wei LI, Jonathan WILHELM, Baran SUMER
  • Magnetic domain wall drift for an artificial leaky integrate-and-fire neuron
    Patent number: 11514301
    Abstract: The present disclosure provides a domain wall magnetic tunnel junction device. Integration of input spikes pushes a domain wall within a ferromagnetic track toward a magnetic tunnel junction (MTJ). An energy gradient within the track pushes the domain wall away from the MTJ by leaking accumulated energy from the input spikes. If the integrated input spikes exceed the energy leak of the gradient within a specified time period, the domain wall reaches the MTJ and reverses its resistance, producing an output spike. The leaking energy gradient can be created by a magnetic field, a trapezoidal shape of the ferromagnetic track, or nonuniform material properties in the ferromagnetic track.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: November 29, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Joseph S. Friedman, Wesley H. Brigner, Naimul Hassan, Xuan Hu
  • Annular axial mixing system for gas-liquid flow
    Patent number: 11511287
    Abstract: An annular axial mixing system for combined gas and liquid flow. The system includes a gas-liquid separator to separate a multiphase gas and liquid into a gas flow and a liquid flow. A lower leg in communication with the gas-liquid separator is configured to receive liquid flow. An upper leg in communication with the gas-liquid separator is configured to receive gas flow. An annular mixing chamber receives gas from the upper leg. A static liquid chamber, at least a portion of which is within the mixing chamber, is in communication with the lower leg and includes perforations therein to receive gas bubbles from the gas in the annular mixing section chamber in order to mix the flows.
    Type: Grant
    Filed: December 19, 2020
    Date of Patent: November 29, 2022
    Assignee: The University of Tulsa
    Inventors: Srinivas Swaroop Kolla, Ramin Dabirian, Ram S. Mohan, Ovadia Shoham
  • Fibrinogen-like protein 2 (FGL2) monoclonal antibodies and their use in cancer detection and treatment
    Patent number: 11512141
    Abstract: Provided herein are anti-FGL2 monoclonal antibodies. Further provided herein are methods to reverse suppressive immune mechanisms, such as for the treatment of cancer or infectious diseases.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: November 29, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Shulin Li, Jun Yan, Jiemiao Hu, Xueqing Xia, Qingnan Zhao
  • Information processing device, mixing device using the same, and latency reduction method
    Patent number: 11516581
    Abstract: An information processing device includes a first time-frequency converter configured to perform a time-frequency conversion with respect to an input signal, using a window function having a first width, a second time-frequency converter configured to perform a time-frequency conversion with respect to the input signal, using a second window function having a second width smaller than the first width, and a modification processing unit configured to modify an output of the second time-frequency converter, using a frequency analysis result based on an output of the first time-frequency converter.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 29, 2022
    Assignees: The University of Electro-Communications, Hibino Corporation
    Inventors: Kota Takahashi, Tsukasa Miyamoto, Yoshiyuki Ono, Yoji Abe
  • Compositions and methods for organ specific delivery of nucleic acids
    Patent number: 11510880
    Abstract: The present disclosure provides compositions which shown preferential targeting or delivery of a nucleic acid composition to a particular organ. In some embodiments, the composition comprises a steroid or sterol, an ionizable cationic lipid, a phospholipid, a PEG lipid, and a permanently cationic lipid which may be used to deliver a nucleic acid.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: November 29, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Qiang Cheng, Tuo Wei, Daniel J. Siegwart
  • Solid electrolyte membrane and use thereof in batteries
    Patent number: 11515556
    Abstract: The presently disclosed subject matter relates generally to a highly ionically conductive solid electrolyte membrane and to batteries comprising such solid electrolyte membrane.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: November 29, 2022
    Assignees: North Carolina Agricultural and Technical State University, The University of North Carolina at Greensboro
    Inventors: Sung-Jin Cho, Alla Letfullina
  • Efficient and secure distributed signing protocol for mobile devices in wireless networks
    Patent number: 11516658
    Abstract: The techniques described herein may provide an efficient and secure two-party distributed signing protocol for the identity-based signature scheme described in the IEEE P1363 standard. For example, in an embodiment, a method may comprise generating a distributed cryptographic key at a key generation center and a first other device and a second other device and generating a distributed cryptographic signature at the first other device using the second other device.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: November 29, 2022
    Assignee: Board of Regents, The University of Texas System
    Inventors: Debiao He, Kim Kwang Choo
  • Ultrasound shear wave vibro-elastography of the abdomen
    Patent number: 11510652
    Abstract: A system useful for performing ultrasound elastography of organs such as the liver allows efficient and robust data acquisition. The system may be applied to perform real-time, noninvasive ultrasound imaging of the liver in humans. Steady-state, shear wave absolute elastography is used to measure the Young's modulus of the liver tissue. This method involves the use of an external exciter or vibrator to shake the tissue and generate a shear wave. Accurate placement of an ultrasound transducer facilitates measurement of the tissue motion due to the shear wave. The stiffness of tissues in the region being imaged may be computed from the measured tissue motions. The following innovations address both vibrator and transducer placement, as well as some specific methods to ensure adequate wave propagation, in order to obtain accurate and consistent measurements.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: November 29, 2022
    Assignee: The University of British Columbia
    Inventors: Septimiu Salcudean, Robert Rohling, Mohammad Honarvar, Julio Raul Lobo, Caitlin Marie Schneider
  • Downhole strain sensor
    Patent number: 11512589
    Abstract: A device for measuring strain on the exterior of a pipe includes a body comprising a top portion and a bottom portion; one or more elastically deformable members coupled between the top portion and the bottom portion, wherein each of the one or more elastically deformable members have an outer contact surface and an inner non-contact surface. One or more sensors are disposed on the inner non-contact surface of one or more of the elastically deformable members. The sensors, during use, provide data that can be used to determine changes in strain on the exterior of the pipe. In another embodiment, one or more sensors are embedded in, or attached to, a casing disposed in a wellbore. In an embodiment, a method includes pressurizing or depressurizing the wellbore with a fluid and measuring the strain induced in the casing (or in an open wellbore) in response to this change in wellbore pressure.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: November 29, 2022
    Assignee: The Board of Regents of The University of Texas System
    Inventors: Rodney Thompson Russell, Mukul Sharma
  • Biofilm disrupting composition for use on chronic wounds
    Patent number: 11510960
    Abstract: A biofilm disrupting composition for use on chronic wounds comprising (i) at least one biologically acceptable thiol based antioxidant (ii) at least one biofilm disruptor and (iii) at least one biocide. Also disclosed is a process of preparing the composition. Also disclosed is the use of the composition for the manufacture of a medicament for the treatment of a chronic wound, and a method of treating a chronic wound in a patient comprising administering the biofilm disrupting composition.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: November 29, 2022
    Assignees: Whiteley Corporation PTY LTD, The University of Sydney
    Inventors: Theerthankar Das Ashish Kumar, Jim Manos, Gregory Stuart Whiteley, Trevor Owen Glasbey
  • Functionally-interdependent shape switching nucleic acid nanoparticles
    Patent number: 11512313
    Abstract: The description provides a molecular switch comprising at least two nanoparticles, wherein a first nanoparticle comprises DNA and/or RNA oligonucleotides, and a second nanoparticle which is complementary to the first nanoparticle comprises reverse complementary DNA and/or RNA oligonucleotides of the first nanoparticle; wherein the complementary nanoparticles interact under physiological conditions leading to thermodynamically driven conformational changes in the first and second nanoparticles leading to their re-association to release one or more duplexes comprising said DNA and/or RNA oligonucleotides and the reverse complementary DNA and/or RNA oligonucleotides, and wherein the nanoparticles are not rings and have no single stranded toeholds.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: November 29, 2022
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The University of North Carolina at Charlote
    Inventors: Bruce Allen Shapiro, Kirill Andreevich Afonin, Eckart H. U. Bindewald, Mathias D. Viard, Wojciech Kasprzak, Marina A. Dobrovolskaia, Justin R. Halman
  • Coated fiber optic chemical and radiation sensors
    Patent number: 11513078
    Abstract: Distributed fiber optic sensors formed by covering the fibers with tubing are provided. The tubing including responsive materials formulated or configured to, responsive to exposure to one of a target chemical species and a target radiation particle, change a relative size and generate a localized effect on or in the optical fiber.
    Type: Grant
    Filed: November 2, 2020
    Date of Patent: November 29, 2022
    Assignees: Consolidated Nuclear Security, LLC, The University of Tennessee Research Foundation
    Inventors: Vincent E. Lamberti, Dayakar Penumadu
  • IMMUNE CELLS FOR ADOPTIVE CELL THERAPIES
    Publication number: 20220370495
    Abstract: Provided are methods for the production of infinite immune cells with an increased lifespan and high proliferation rates by engineering them to express BCL6 and a cell survival-promoting gene. Further provided herein are methods for the production and use of the infinite immune cells for the treatment of diseases, such as cancer.
    Type: Application
    Filed: August 19, 2020
    Publication date: November 24, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Sattva S NEELAPU, Jingwei LIU
  • HLA-RESTRICTED VCX/Y PEPTIDES AND T CELL RECEPTORS AND USE THEREOF
    Publication number: 20220372092
    Abstract: Provided herein are tumor-antigen VCX/Y specific peptides. Also provided herein are methods of generating VCX/Y-specific immune cells and their use for the treatment of cancer. Immunogenic compositions comprising VCX/Y-specific peptides are also provided. In a further embodiment, there is provided a protein complex comprising a peptide according to any of the embodiments and aspects described above in complex with HLA. In some aspects, the HLA is a HLA-A11, HLA-DR, or HLA-DQ.
    Type: Application
    Filed: October 16, 2020
    Publication date: November 24, 2022
    Applicant: Board of Regents, The University of Texas System
    Inventors: Cassian YEE, Ke PAN
  • HEAT EXCHANGE PROMOTION MEMBER AND HEAT EXCHANGER
    Publication number: 20220373270
    Abstract: Provided is a heat exchange promotion member and a heat exchanger that can improve heat transfer performance while holding down an increase in pressure drag of a fluid that exchanges heat with the heat exchange promotion member. A heat dissipation fin 14 of the present invention is a heat exchange promotion member that exchanges heat with a flowing fluid. The heat dissipation fin 14 includes a planar part 12 which is a surface substantially parallel to the fluid flowing direction and a raised part 13 that protrudes from the planar part 12 toward the fluid. The raised part 13 has a portion slanted relative to the direction in which the fluid flows, and there are a plurality of the raised parts 13 formed spaced apart from one another in the fluid flowing direction.
    Type: Application
    Filed: September 23, 2020
    Publication date: November 24, 2022
    Applicants: Atago Manufacturing Co., Ltd., The University of Tokyo, DENSO CORPORATION
    Inventors: Noboru Otomo, Ken Yamamoto, Kenichi Morimoto, Yuji Suzuki
  • MATERIALS AND METHODS USEFUL TO INDUCE CANCER CELL DEATH VIA METHUOSIS OR AUTOPHAGY OR A COMBINATION THEREOF
    Publication number: 20220370430
    Abstract: Compounds, compositions, and methods useful for inducing cancer cell death via methuosis, autophagy, or a combination thereof, are described. The compounds have a 4-pyridyl group linked by a heterocyclic group to an aryl, heteroaryl, aralkyl, or heteroaryl alkyl.
    Type: Application
    Filed: July 11, 2022
    Publication date: November 24, 2022
    Applicant: The University of Toledo
    Inventors: Amit K. Tiwari, Chandrabose Karthikeyan, Haneen A. Amawi, Paul W. Erhardt, Piyush Trivedi