Abstract: Disclosed is a compound of formula (I): in which all symbols are defined in the description. Also disclosed are pharmaceutical compositions including the compounds, methods of making the compounds, kits comprising the compounds and methods of using the compounds to treat disorders associated with dysregulation of TREK-1, TREK-2 or both TREK-1 and TREK-2 in a mammal.

Abstract: A circuit for charging a rechargeable battery is described. The circuit includes a first DC voltage source, a bus capacitor Cbus, an H-bridge circuit, a rechargeable battery, a second DC voltage source, an impedance meter and a microcontroller. The impedance meter measures an impedance of the rechargeable battery. The microcontroller is connected to the impedance meter and to each gate contact. The microcontroller generates a set of drive signals that are configured to generate a sinusoidal with ripple current at an output terminal of the H-bridge circuit. The microcontroller adjusts a frequency of the sinusoidal with ripple current based on the impedance of the rechargeable battery and identifies a frequency of the sinusoidal with ripple current at which the rechargeable battery has a minimum internal impedance. The microcontroller adjusts the set of drive signals to generate the sinusoidal with ripple current at the identified frequency and recharge the rechargeable battery.

Abstract: The present disclosure provides a task-independent brainprint recognition method based on feature disentanglement by decorrelation. Existing methods fail to mine inherent identity information of a brain, leading to poor robustness of brainprint recognition in a scenario across tasks and difficulty of promotion thereof in practical use. The present disclosure firstly uses two branch networks to perform coarse-grained decomposition of identity information and task related information in an electroencephalogram (EEG). Secondly, in consideration of an influence of a task state on the identity information, a decorrelating method is employed such that the identity information and the task related information are independent as much as possible. Finally, a brainprint feature in the EEG is fully utilized for classification by adversarial self-supervision.

Abstract: A friction stir welding tool and a friction stir welding method that can increase the amount of heat generation, while reducing the amount of escaping heat are provided. The friction stir welding tool (1) has a shoulder portion (7) and a probe portion (5) provided on a bottom surface of the shoulder portion (7) . The base material of the friction stir welding tool (1) is a ceramic material whose main phase is silicon nitride or sialon. The shoulder portion (7) has a diameter of 35 mm or greater.

Abstract: The present disclosure relates to a xanthene derivative compound with a high refractive index and a manufacturing method therefor. More specifically, provided herein is a compound that has a xanthene-based complex cardo structure and a high refractive index and can be used as a monomer in optical resins requiring a refractive index of 1.7 or higher, and a (co)polymer and an optical lens manufactured therefrom. Given, the xanthene-based complex cardo structure of the compound maximally suppresses the fluidity of the molecular chains and can find applications in the production of resins with high glass transition temperature and excellent thermal stability.

Abstract: It is an object of the present invention to provide a fusion protein of a molecule that recognizes cancer cells or the like and a mutant streptavidin, wherein the fusion protein is for use in the treatment or diagnosis of a cancer. According to the present invention, provided is a fusion protein, wherein an antigen-binding molecule having a molecular weight of 20,000 or less is bound, via a linker sequence, to the N-terminal side and/or C-terminal side of the amino acid sequence as set forth in SEQ ID NO: 1, provided that the C-terminal amino acid sequence consisting of Pro-Ser-Ala-Ala-Ser His-His-His-His-His-His may be partially or entirely deleted.

Abstract: Methods for the treatment of condition associated with bromodomain and extraterminal domain (BET) protein activity are disclosed. The methods include administering a therapeutically effective amount of a piperazine BET protein inhibitor or a piperidine BET protein inhibitor to a subject in need thereof. Piperazine BET protein inhibitors, piperidine BET protein inhibitors, and pharmaceutical compositions comprising the BET proteins inhibitors are also described.

Abstract: Sensors include an optical source configured to emit a beam directed to an opposing surface having a reflectance pattern, and an optical detector situated in relation to the optical source to detect a portion of the beam reflected by the opposing surface and to produce an output signal that varies based on (i) a relative displacement between the reflectance pattern and the optical detector and (ii) a spatially variable reflectance resulting from the relative displacement. Reflectance patterns can be spatially variable and/or randomly arranged. Displacements in a compressive or tensile direction can be detected. Methods of operation and fabrication of sensors are also disclosed.

Abstract: A redox flow battery including: a catholyte including a radical dication of a conjugated heterocyclic carbenium compound; and an anolyte including a neutral radical of a conjugated heterocyclic carbenium compound; wherein the conjugated heterocyclic carbenium compounds present in the catholyte and anolyte are the same compound; and the redox flow battery has an open circuit potential of greater than about 2 V. A redox flow battery including: a catholyte including a conjugated heterocyclic cationic compound in a first oxidation state; and an anolyte including a conjugated heterocyclic cationic compound in a second oxidation state; wherein the first oxidation state is a higher oxidation state than the second oxidation state.

Abstract: Provided herein are compositions and methods useful in the treatment of hearing loss diseases, such as by correction of mutations in genes associated with hearing.

Abstract: The invention describes methods and reagents useful for sequencing polypeptide molecules. The method comprises affixing a polypeptide to a substrate and contacting the polypeptide with a plurality of probes that selectively bind to a terminal amino acid or a terminal amino acid derivative. Probes bound to the polypeptide molecule are then identified before cleaving the terminal amino acid or terminal amino acid derivative of the polypeptide. Also provided are probe compositions comprising (a) a ClpS variant comprising at least 80% sequence identity to SEQ ID NO: 1, wherein the ClpS variant binds to an N-terminal amino acid or a N-terminal amino acid derivative with a different selectivity than a wild-type ClpS; and (b) a detectable label.

Abstract: Systems, methods, and other embodiments described herein relate to predicting anomalous operation of a device and an associated remaining useful life (RUL) estimation. In one embodiment, a method includes acquiring usage information about the operation of an electronic device. The method includes determining whether the usage information indicates the presence of an anomaly in the operation of the electronic device according to an anomaly model. The method includes, responsive to detecting the anomaly, determining a remaining useful life (RUL) for the electronic device according to a RUL model. The method includes providing the RUL estimate.

Abstract: System, method and application that obtains, consolidates, and integrates multiple sources of data including Transdermal Alcohol Concentration (TAC) along with drinking diary, photo/video, breath analyzer, other biological data (e.g., heart rate, skin conductance. blood flow, person-level biometrics), and environmental data (e.g., ambient temperature, humidity, GPS) and uses models described herein to convert TAC obtained from a wearable biosensor into estimated Blood Alcohol Concentration (BAC) or Breath Alcohol Concentration (BrAC).

Abstract: An example embodiment of the present disclosure relates to a nanofiber scaffold including polycaprolactone (poly(?-caprolactone; PCL), decellularized extracellular matrix (dECM) and usnic acid (UA), and a preparation method thereof. The nanofiber scaffold of an example embodiment of the present disclosure has a uniform nanofiber structure, good fluid absorption and retention, moderate release rate, high mechanical stability, thermal stability, and semi-crystalline structure, and exhibits excellent antibacterial efficacy against fungi/bacteria such as Candida albicans, and good compatibility with human-derived fibroblasts.

Abstract: A method for promoting the rapid precipitation of travertine crystals by algae is disclosed. Microalgae is added to a body of water having a calcium ion concentration of 100-500 mg/L and stirred. The amount of microalgae is 0.1-8×108 cells/L. The invention adopts a method for promoting the rapid precipitation of travertine crystals by algae, which significantly improves the sedimentation rate of travertine crystals. At the same time, there are pseudomonas in the calcified water body of algae, which can be used for algae-lysing bacteria isolation and purification.

Abstract: A pneumatic soft dexterous hand for a patient with missing finger functions and a soft robot relate to the technical field of soft robots. The pneumatic soft dexterous hand includes a soft finger, the soft finger includes a rubber casing, a silicone tube, an endoskeleton, and a built-in air bag, and the silicone tube is sleeved in the rubber shell. The silicone tube is formed with a chamber, and the endoskeleton and the built-in airbag are arranged in the silicone tube. The endoskeleton includes a plurality of skeleton modules hinged together, the plurality of the skeleton modules are divided into two groups, and the skeleton modules of the two groups are hinged in an alternating manner in sequence from left to right. The built-in airbag is embedded on the endoskeleton to support the endoskeleton.

Abstract: One embodiment of the present invention provides an atomic layer deposition device for filling a gap of a semiconductor structure with a high aspect ratio and a method of manufacturing the same. According to the atomic layer deposition method of filling the gap of the semiconductor structure with the high aspect ratio according to one embodiment of the present invention, it is possible to remove an overhang at an pattern top at the same time as deposition and perform the gap-filling to remove a void and a seam by improving bottom-up deposition in a high aspect ratio structure of 40:1 or more.

Abstract: The present invention discloses an integrated braiding and needle punching preform forming method, comprising the following steps: arranging gripping devices at both ends of a braiding machine, allowing a mandrel to move in a certain direction along the axis of the braiding machine while forming a first layer of fabric on a surface of the mandrel; then laying felt on top of the first layer of fabric by using an automatic felt laying device, and employing a needle punching device to perform pre-needle punching on the felt layer to ensure the felt adheres to the braided fabric surface; restarting the braiding machine, moving the mandrel in an opposite direction while forming a second layer of fabric on a surface of the felt; repeating the above steps to achieve multiple layers of braided fabric and felt in alternate adhesion; finally, performing main needle punching on the preform.

Abstract: Methods are disclosed for inhibiting esophageal inflammation in a subject, that include administering to the esophagus of the subject with esophageal inflammation a therapeutically effective amount of an extracellular matrix (ECM) hydrogel. Methods are also disclosed for reducing esophageal stricture. Compositions are disclosed that include an esophageal extracellular matrix (ECM) hydrogel.

Abstract: A method for providing a semi-device-independent random output signal, and a system for providing a semi-device-independent random output signal. The method comprises the steps of providing respective coherent laser signals of a same optical mode in a signal arm and a local oscillator arm between a quantum signal source, Alice, and at a quantum signal detector, Bob; Alice and Bob randomly selecting operation in a test mode or a randomness generation mode for each of n rounds; generating a raw random string from bit values bi of rounds in which randomness generation mode was chosen, and using rounds in which test mode was chosen to estimate an entropy of the raw random string.