Abstract: Provided herein are methods and compositions for the treatment of cancer by modulating the microbiome to enhance the efficacy of immune checkpoint blockade. The microbiome may be modulated by the administration of butyrate and/or butyrate-producing bacteria. Also provided herein are methods of determining a response to an immune checkpoint inhibitor by identifying if a subject has a favorable microbial profile.

Abstract: Apparatus and method estimate a position of a movable stage. The apparatus comprises: a stator comprising 2D array of sensors arranged relative to one another to provide a plurality of stator-Y oriented sensor columns and a plurality of stator-X oriented sensor rows; a movable stage comprising a first Y-magnet array comprising a plurality of first magnetization segments generally linearly elongated in a stage-Y direction, each first magnetization segment having a stage-Y direction length, Lyy, and a magnetization direction generally orthogonal to the stage-Y direction, the magnetization directions of the plurality of first magnetization segments exhibiting a first magnetic spatial period ?x over a stage-X direction width, Wyx, of the first magnet array; and a controller connected to receive information based on an output from each of the sensors and configured to use the information to determine a stator-X direction position of the movable stage.

Abstract: A coating composition may include a polymeric binder and bacteria that exhibit biologically induced mineralization (BIM) or biologically controlled mineralization (BCM) of calcium carbonate (CaCO3) in the presence of environmental calcium. The bacteria may exhibit BIM or BCM of CaCO3 using the ChaA antiporter protein. The coating formulations may be used to form coatings that exhibit self-healing properties in response to damage, such as a cut, tear, puncture, abrasion, or the like. For example, in response to being exposed to the damage, the bacteria may utilize nutrients, a calcium source, and water to cause precipitation of CaCO3 at the site of the damage. The nutrients, the calcium source, and the water may be provided as part of the coating formulation, as part of another layer of a coating system, from an external source (e.g., an applied spray or wash), or combinations thereof.

Abstract: A method of monitoring a condition of a SiC MOSFET can include (a) applying a first test gate-source voltage across a gate-source of a SiC MOSFET in-situ, the first test gate-source voltage configured to operate the SiC MOSFET in saturation mode to generate a first drain current in the SiC MOSFET, (b) applying a second test gate-source voltage across the gate-source of the SiC MOSFET in-situ, the second test gate-source voltage configured to operate the SiC MOSFET in fully-on mode to generate a second drain current in the SiC MOSFET, (c) determining a drain-source saturation resistance using the first drain current to provide an indication of a degradation of a gate oxide of the SiC MOSFET; and (d) determining a drain-source on resistance using the second drain current to provide an indication of a degradation of contact resistance of the SiC MOSFET.

Abstract: Described herein are pH responsive compounds, micelles, and compositions useful for the detection of primary and metastatic tumor tissues. Compounds described herein are imaging agents useful for the detection of primary and metastatic tumor tissue (including lymph nodes). Real-time fluorescence imaging during surgery aids surgeon in the detection of metastatic lymph nodes or delineate tumor tissue versus normal tissue, with the goal of achieving negative margins and complete tumor resection.

Abstract: The disclosure provides methods and compositions for inhibiting pain and comorbid cognitive deficits by administering a MNK inhibitor to a subject in need thereof. Also provided are methods of using the inhibitor in combination with other pain therapies.

Abstract: Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

Abstract: A system and method estimate the fault severity index and consequently the number of shorted turns in permanent magnet motors (PMSM) with inter turn short circuit fault (ITSC). In this method, the machine is excited with DC current at stand still conditions to obtain the winding resistance seen by the d-axis of the machine. The estimated d-axis resistance contains useful information pertaining to the fault severity index, and is used to extract the fault severity index and the number of shorted turns in the faulty motor. The method enables the estimation of fault severity index without complex modeling with different machine prototypes, or FEA models to analyze the relationship between machine currents and short circuit current. To enhance the accuracy of the estimation method, this disclosure addresses issues associated with inverter non-linearity effects such as distortion voltage due to dead time effects and voltage drops across the switching devices.

Abstract: The present invention provides, for example, a set of two polypeptides exhibiting the nuclease activity with dependence on light or in the presence of a drug, in which an N-terminal side fragment and a C-terminal side fragment of a Cas9 protein are bound to each of two polypeptides which form a dimer with dependence on light or in the presence of a drug.

Abstract: The subject matter described herein relates to methods for polymer xanthylation and the xanthylated polymers produced by such methods. Subsequent replacement of the xanthylate moiety allows facile entry into functionalized polymers.

Abstract: An environmentally friendly (e.g. no acid, base, or cyanide) system and process for large scale extraction of metal ion into aerobic molten salt (or ionic liquid) and the electrodeposition of metal (e.g. copper, gold, silver, etc.) from the metal ion dissolved in the molten salt. The non-volatile low vapor pressure liquid salt is reusable, and heat from the molten slag can heat the molten salts or ionic liquids. Another embodiment comprises a one-pot apparatus for the extraction of metal (e.g. copper) from metal earths and electrodepositing the metal using a low melting (209° C.) aerated Na—K—Zn chloride salt in which copper metal oxidizes and is converted to soluble copper chloride. When an electrical power supply is connected to the graphite vessel (cathode) and to copper rods in the melt (anodes), then the copper chloride is deposited as copper metal by electroreduction on the bottom of the graphite reaction vessel.

Abstract: Nanoparticles comprising micheliolide (MCL) or derivatives thereof, and optionally additional therapeutic agents, such as chemotherapeutic agents, are described. Also described are methods of treating diseases, such as cancer, comprising the use of combinations of MCL or a derivative thereof with X-ray irradiation and/or other therapeutic agents, such as immune checkpoint inhibitors. The use of the combinations can provide synergistic anticancer therapeutic efficacy, for example, as the MCL or derivative thereof can both sensitize cancer cells to therapy and target resistant cancer stem cells (CSCs) for selective cell death.

Abstract: The present invention provides for organometallic and organic dopants suitable for use in organic carrier transporting materials. Also provided are organic light emitting devices containing doped organic carrier transporting materials.

Abstract: A tunnel boring machine includes: a disc cutter including a cutter ring; and a member for use in measurement of a wear amount of the cutter ring with a three-dimensional shape measurement device, in which the member is provided at a part constant in relative position to the cutter ring.

Abstract: A radiation powered device includes a first electrode, a second electrode, a semiconductor disposed between the first and second electrodes, and a radioactive source configured to generate a flow of electrons through the semiconductor between the first and second electrodes, wherein the semiconductor comprises diamond material, wherein the radioactive source is embedded within the diamond material, wherein the radioactive source comprises a beta-emitting radioisotope, and atoms of the radioisotope are either substitutionally or interstitially integrated into the diamond material, wherein the diamond material comprises a plurality of regions in the form of layers within a continuous crystal lattice of the diamond material, and wherein at least one layer of the diamond material comprises the radioactive source and at least one layer of the diamond material does not comprise the radioactive source.

Abstract: The present disclosure provides radiolabeled compounds of the formula: (I) and (II), as well as precursor compounds of the formula: (VII) wherein the variables are defined herein. The present disclosure also provides radiopharmaceutical compositions comprising the radiolabeled compounds disclosed herein as well as precursor compositions comprising the precursor compounds disclosed herein. The present disclosure further provides methods of imaging using the radiolabeled compounds and/or radiopharmaceutical compositions of the present disclosure as well as kits for the preparation of the radiolabeled compounds and radiopharmaceutical compositions disclosed herein.

Abstract: To provide translation techniques for translating a natural language representation in one language into a natural language representation in another language using sound. With L1 and L2 being different languages from each other, a translation data generation apparatus includes: a latent variable generation unit that generates, from a natural language representation in the language L1, a latent variable corresponding to the natural language representation in the language L1 using a language L1 encoder; an index calculation unit that calculates an index for the natural language representation in the language L1 from the natural language representation in the language L1; and a natural language representation generation unit that generates a natural language representation in the language L2 corresponding to the natural language representation in the language L1 from the latent variable and the index for the natural language representation in the language L1 using a language L2 decoder.

Abstract: Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface. Typically, the cyclopropanated structural analog has the structure according to formula (I): wherein R1 is a C1-C24 linear or branched alkyl group; or an acid halide or acid anhydride thereof.

Abstract: A computer-implemented method, system and computer program product for compressing video. A set of video frames is partitioned into two subsets of different types of frames, a first type and a second type. The first type of frames of videos is compressed to generate a first representation by a first stage encoder. The first representation is then decoded to reconstruct the first type of frames using a first stage decoder. The second type of frames of video is compressed to generate a second representation that only contains soft edge information by a second stage encoder. A generative model corresponding to a second stage decoder is then trained using the first representation and the reconstructed first type of frames by using a discriminator employed by a machine learning system. After training the generative model, it generates reconstructed first and second types of frames using the soft edge information.

Abstract: A computer implemented method for searching electronic documents, and associated system and computer program product. The method includes receiving an input representing an example-based search query and processing the input. The method also includes determining, for each of the electronic documents, a relevance score between the input and the corresponding electronic document. The determination is based on, at least, textual similarity between the input and the corresponding electronic document, topical similarity between the input and the corresponding electronic document, as well as linkage relationship in a linkage network of the plurality of electronic documents. The method also includes determining, based on the determined relevance scores, a search result containing one or more of the electronic documents. The search results will be provided to the user.