Patents Assigned to The US, as Represented by the Secretary, Department of Health and Human Services
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Publication number: 20100016409Abstract: The instant invention provides polyvalent RNA nanoparticles comprising RNA motifs as building blocks that can form RNA nanotubes. The polyvalent RNA nanoparticles are suitable for therapeutic or diagnostic use in a number of diseases or disorders.Type: ApplicationFiled: May 31, 2007Publication date: January 21, 2010Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Yaroslava G. Yingling, Bruce A. Shapiro
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Publication number: 20090258002Abstract: The invention relates to methods of accurately and quickly diagnosing and monitoring the progression of cancer and ischemally injured tissue. The invention also provides methods of treatment as well as methods of screening for compositions useful for treating the disorders.Type: ApplicationFiled: February 1, 2006Publication date: October 15, 2009Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: J. Carl Barrett, Joseph Riss
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Publication number: 20090214510Abstract: The instant invention provides compositions and methods for the treatment of viral infections caused by enveloped viruses comprising phospholipase nucleic acid molecules or polypeptides, or fusion molecules comprising phospholipase molecules or functional fragments thereof.Type: ApplicationFiled: February 21, 2007Publication date: August 27, 2009Applicant: Government of the US as represented by the Secretary, Department of Health and Human ServicesInventors: Gary J. Nabel, Jae Ouk Kim
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Publication number: 20090131536Abstract: The present invention features methods of treating renal cancer by administration of certain dimethylsulfonate compounds. The present invention further features administration protocols and dosing schedules for methods of treating patients suffering from renal cancer and pharmaceutical compositions suitable for use in the treatment methods provided herein.Type: ApplicationFiled: October 14, 2005Publication date: May 21, 2009Applicant: GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICESInventors: Susan D. Mertins, Susan E. Bates, David G. Covell, Geoffrey W. Patton, Melinda G. Hollingshead, Rao Vishnuvajjalla
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Publication number: 20090111762Abstract: The invention relates to method of diagnosing and treating cancer, in particular ?-catenin related cancers. The invention further relates to methods of identifying CTNNB1 related cancer CTNNB1 therapeutics.Type: ApplicationFiled: February 10, 2006Publication date: April 30, 2009Applicant: Govt. of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Mark J. Roth, Konrad Huppi
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Publication number: 20090068234Abstract: The instant invention provides compositions for the treatment of cancer. Specifically, the invention provides polypeptides and nucleic acid molecules comprising tumor-associated embryonic antigens, e.g., OFA-iLRP, and chemoattractant ligands, e.g., a proinflammatory chemokine such as MIP3?/CCL20 or ?-defensin mDF2?. The invention further provides cancer vaccines and methods for treating subjects having, or at risk of developing, cancer.Type: ApplicationFiled: September 3, 2007Publication date: March 12, 2009Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Arya Biragyn, Dan Longo, Igor Espinoza-Delgado
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Publication number: 20090035763Abstract: The invention provides methods for identifying conditions of low grade cervical dysplasia and assessing the progressive potential of individual lesions to develop into high grade cervical dysplasia and cervical squamous cell cancer as well as cervical adenocarcinoma.Type: ApplicationFiled: February 21, 2006Publication date: February 5, 2009Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Thomas Reid, Kerstin Heselmeyer-Haddad, Winfried Steinberg, Gert Auer, Sonia Andersson, Catharina Larsson
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Publication number: 20080311616Abstract: The present invention features hydrophilic IR-transparent porous membranes, particularly hydrophilic IR-transparent porous polyethylene membranes and methods of preparing the hydrophilic membranes by treatment of hydrophobic IR-transparent porous membranes with plasma. The present invention further features spectroscopic sample holders which incorporate the hydrophilic IR-transparent porous membranes and methods of identifying bacteria and other microorganisms in samples by infrared spectroscopy.Type: ApplicationFiled: April 23, 2008Publication date: December 18, 2008Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Magdi Mossoba, Suflan Al-Khaldi
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Publication number: 20080306130Abstract: The present invention features pyrazolidinyl compounds, pharmaceutical compositions of substituted pyrazolidinyl compounds and methods of treating a patient suffering from cancer or viral infection, the method comprising administering to a patient one or more pyrazolidinyl compounds of the invention.Type: ApplicationFiled: May 19, 2008Publication date: December 11, 2008Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Allan M. Weissman, Yili Yang, Jane P. Jensen
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Publication number: 20080199905Abstract: Disclosed are mutants of galactosyltransferases that can catalyze formation of oligosaccharides in the presence of magnesium; mutants of galactosyltransferases having altered donor and acceptor specificity which can catalyze formation of oligosaccharides in the presence of magnesium; methods and compositions that can be used to synthesize oligosaccharides; methods for increasing the immunogenicity of an antigen; and methods to stabilize platelets.Type: ApplicationFiled: December 6, 2004Publication date: August 21, 2008Applicant: Goverment of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Pradman Qasba, Elizabeth Boeggeman, Boopathy Ramakrishnan
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Publication number: 20080039518Abstract: The present invention features maleiimide compounds, pharmaceutical compositions of maleiimide compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more maleiimide compounds of the invention.Type: ApplicationFiled: August 22, 2006Publication date: February 14, 2008Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Christopher Michejda, Wei Yao, Brian Carr, Siddhartha Kar, Maria Michejda
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Publication number: 20080008762Abstract: The invention provides steroid-containing pharmaceutical compositions which are free of classical preservatives and preferably comprise a steroid that is sparingly soluble or substantially insoluble in water, particulate steroid having an average particle size of from about 2.2 to about 10 microns. The pharmaceutical compositions can be used to treat medical conditions, including ophthalmological and back pain conditions.Type: ApplicationFiled: November 17, 2005Publication date: January 10, 2008Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Michael Robinson, George Grimes, Luisa Gravlin, Gopal Potti, Peng Yuan, Karl Csaky
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Publication number: 20070134749Abstract: The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.Type: ApplicationFiled: December 1, 2006Publication date: June 14, 2007Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Lawrence Samelson, Weiguo Zhang
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Publication number: 20070134767Abstract: The present invention provides nucleic acid molecules comprising expressible sequences, including reporter genes and therapeutic genes, whose expression is dependent on the presence of both HIV Tat and Rev proteins. Further provided are methods for detecting HIV, method for identifying compounds that can inhibit HIV infection and/or gene expression, methods for killing HIV-infected cells, and methods of treating HIV-infected subjects.Type: ApplicationFiled: September 28, 2004Publication date: June 14, 2007Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Yuntao Wu, Jon Marsh
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Publication number: 20060257361Abstract: The present invention relates to Fc-IL-15 hybrids, which may or may not include peptide linkers between the IL-15 and the Fc portion, for methods of treatment of tumors and viral infections. The IL-15 hybrids can be Fc-IL-15 or IL-15-Fc hybrids. The Fc-IL-15 hybrids include variants, including the IL-15 and Fc variants. The hybrids preferably (but not necessarily) include peptide linkers between the IL-15 and the Fc portion. These linkers are preferably composed of a T cell inert sequence, or any non-immunogenic sequence.Type: ApplicationFiled: April 12, 2006Publication date: November 16, 2006Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Morihiro Watanabe, Hiroshi Yazawa, John Ortaldo, Robert Wiltrout
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Publication number: 20060159667Abstract: Methods for generating highly enriched Th1/Tcl and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer.Type: ApplicationFiled: December 9, 2005Publication date: July 20, 2006Applicants: Gov. of the US, as represented by the Secretary, Department of Health and Human Services, The Trustees of the University of PennsylvaniaInventors: Daniel Fowler, Unsu Jung, Ronald Gress, Bruce Levine, Carl June
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Publication number: 20060148696Abstract: The instant invention relates to methods for treating a subject suffering from or susceptible to an autoimmune disease or disorder, or a disease or disorder having an autoimmune component, comprising administering to the subject an effective amount of cyclophilin or a biologically active fragment thereof.Type: ApplicationFiled: July 8, 2005Publication date: July 6, 2006Applicant: Government of the US, as represented by the Secretary, Department of Health and Human ServicesInventors: Julio Aliberti, Jose Riberio, John Andersen, Hana Golding, Alan Sher
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Publication number: 20060147419Abstract: The invention is directed to compositions capable of augmenting the immunogenicity of a vaccine. The composition, or adjuvant, is administered to a mammal in need thereof in sequential or concurrent combination with a vaccine antigen. In one preferred aspect, the adjuvant is provided in the form of a recombinant poxvirus vector, such as a vaccinia virus vector, which comprises a nucleic acid sequence encoding IL-15.Type: ApplicationFiled: December 15, 2003Publication date: July 6, 2006Applicant: GOVERNMENT of the US, as represented by the Secretary , Department of Health and Human ServiceInventors: Liyange Perera, Thomas Waldmann, Sang-Kon Oh, Jay Berzofsky
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Publication number: 20060058251Abstract: Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as a synthetic adjuvant.Type: ApplicationFiled: March 6, 2003Publication date: March 16, 2006Applicants: University of Iowa Research Foundation, The US, as Represented by the Secretary, Department of Health and Human Services, Coley Pharmaceutical Group, Inc.Inventors: Arthur Krieg, Dennis Klinman, Alfred Steinberg