Patents Assigned to The US, DHHS, NIH
  • EPOXY-GUAIANE DERIVATIVES AND TREATMENT OF CANCER
    Publication number: 20100286259
    Abstract: Disclosed are englerins and derivatives (I) thereof useful in the treatment of a number of cancers, particularly renal cancer, as well as pharmaceutical compositions and method of treating a patient with the use of these derivatives. The englerins, for example Englerin A and Englerin B, can be isolated from the plant Phyllanthus engleri or produced by synthetic methods. An example of the englerin derivative is 2?-chloroenglerin A, which has the structure (II), wherein double bond ‘a’ is E, Z, or a mixture of E and Z.
    Type: Application
    Filed: December 30, 2008
    Publication date: November 11, 2010
    Applicant: The US, DHHS, NIH
    Inventors: John A. Beutler, Ranjala Ratnayake, David Covell, Tanya R. Johnson