Abstract: Methylation of DNA can be a critical step in the introduction of DNA into P. haemolytica. A methyltransferase has been isolated and molecularly cloned for this purpose. Use of the methyltransferase has allowed construction of defined, attenuated mutants for use as vaccines to protect cattle.
Type:
Application
Filed:
February 4, 2004
Publication date:
January 6, 2005
Applicants:
The USA as Represented by the Department of Agriculture, Biotechnology and Research and Development Corporation