Abstract: A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with complementary motor protein pairs (such as actin and myosin). The actin and myosin interact with one another in the presence of ATP to rotate the cylinders or cones relative to one another, and this rotational energy is harnessed to produce work. The concentration of ATP and the number of nested cylinders or cones can be used to control the rotational speed of the motor. The length of the cylinders can also be used to control the power generated by the motor. In another embodiment, the molecular motor includes at least two annular substrates wherein one annular substrate is coated with a first motor protein and the other annular substrate is coated with a second motor protein. The first and second motor proteins interact with each other to move the second annular relative to the first annular substrate.
Type:
Application
Filed:
April 23, 2014
Publication date:
August 21, 2014
Applicant:
The USA, as represented by the Secretary, Dep. of Health and Human Services
Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
Type:
Application
Filed:
October 11, 2011
Publication date:
March 15, 2012
Applicant:
The Government of the USA as represented by the Secretary of the Dep. of Health and Human Services
Abstract: Materials and Methods for use in treating cell proliferative disorders related to asparagine metabolism are provided. Cell proliferative disorders include such cancers as forms of leukemia, ovarian cancers, melanomas, renal cancers, breast cancers, brain cancers, and other cancers. Methods include the use of RNA interference targeted at asparagine synthetase to enhance the efficacy of L-asparaginase therapies.
Type:
Application
Filed:
June 2, 2011
Publication date:
September 22, 2011
Applicant:
The USA, as represented by the Secretary, Dep. of Health and Human Services
Inventors:
Philip L. Lorenzi, John N. Weinstein, Natasha J. Caplen
Abstract: The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.
Type:
Application
Filed:
July 2, 2008
Publication date:
November 6, 2008
Applicant:
The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human Services
Inventors:
David C. KASLOW, Takafumi Tsuboi, Motomi Torii
Abstract: The invention provides isolated nucleic acid and amino acid sequences of novel human tumor suppressors, antibodies to such tumor suppressors, methods of detecting such nucleic acids and proteins, methods of screening for modulators of tumor suppressors, and methods of diagnosing and treating tumors with such nucleic acids and proteins.
Type:
Application
Filed:
December 21, 2007
Publication date:
July 17, 2008
Applicant:
The Govt. of the USA as represented by the Secretary of the Dep. of Health and Human Services
Abstract: This invention relates to methods of screening for compounds capable of inducing apoptosis in certain tumor cells. The invention also relates to compounds identified by such methods. In addition, the invention relates to methods for the in vitro diagnosis of Xeroderma pigmentosum and compounds useful in these methods.
Type:
Application
Filed:
August 4, 2003
Publication date:
June 17, 2004
Applicant:
The Gov. of the USA as represented by the Secretary of the Dep. of Health and Human Services
Inventors:
Curtis C. Harris, Xin Wei Wang, Jan H.J. Hoeijmakers