Patents Assigned to The USA as represented by the Secretary, Dept. of Health and Human Services; National Institutes of
  • Methods of producing T cell populations enriched for stable regulatory T-cells
    Patent number: 11060059
    Abstract: The present invention provides methods for producing cell populations enriched for stable, regulatory T cells (Tregs). In particular, the invention relates to methods for culturing T cells such that the final culture is enriched for stable, regulatory T cells. It also relates to methods for stabilizing regulatory T cells. Also provided are compositions enriched for stable, regulatory T cells, which are useful for treating individuals in need of such treatment. The methods and compositions disclosed herein can also be used to treat an individual suffering from an immune-mediated disease.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: July 13, 2021
    Assignee: THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES NATIONAL INSTITUTES OF HEALTH
    Inventors: Yong Chan Kim, Ethan Shevach
  • PAPILLOMAVIRUS PSEUDOVIRUSES FOR DETECTION AND THERAPY OF TUMORS
    Publication number: 20130230456
    Abstract: Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP)
    Type: Application
    Filed: February 8, 2013
    Publication date: September 5, 2013
    Applicant: The USA as represented by the Secretary, Dept. of Health and Human Services; National Institutes of
    Inventor: The USA as represented by the Secretary, Dept. of Health and Human Services; National Institute of Health