Abstract: This disclosure relates to CryoArrays, which permit the analysis of samples (such as protein, nucleic acid, virus, or cell samples) in arrays that are prepared at low temperatures. Because CryoArrays are constructed as a block of substantially columnar samples, the block can be sliced to provide a plurality of identical or substantially identical individual arrays. The individual arrays can be used for parallel analysis of the same array feature set, for instance with different probes or under different conditions. Also provided are methods of making CryoArrays, devices for making CryoArrays, and kits.

Abstract: The invention provides methods for using local heat to control gene expression. The heat shock protein (hsp) gene promoter is recombined with a selected therapeutic gene and expressed in selected cells. Local controlled heating is used to activate the hsp promoter, for example by using focused ultrasound controlled by MRI.

Abstract: An onboard power generation apparatus for a hoist conveyance includes a drive wheel carried by the conveyance. The drive wheel is positioned to engage the surface of a stationary structure adjacent the conveyance, such as a shaft guide, so that movement of the conveyance relative to the structure causes rotation of the drive wheel. A charging generator coupled to the drive wheel is operable to produce an electric current upon rotation of the drive wheel. A battery may be electrically connected to the generator so that the generator provides an electric current to recharge the battery. The drive wheel may be mounted for movement relative to the conveyance with biasing mechanism for resiliently biasing the drive wheel toward the surface of the adjacent structure.