Patents Assigned to The Wellcome Foundation Limited
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Publication number: 20020164788Abstract: The present invention relates to a monoclonal antibody, preferably with specificity for CD38, having CDRs of foreign origin and a recipient framework region having a sequence of human or primate origin, wherein the original amino acid residues in position 29 and/or 78 of the sequence of the recipient framework region of the heavy chain is replaced by a replacement amino acid residue that is the same or similar to that in the corresponding position of the sequence of the corresponding framework region of the heavy chain of the antibody from which the CDRs are derived. The invention also relates to a method of preparation of the antibody, a pharmaceutical composition containing the antibody and a method of using the antibody for the treatment of cancer and autoimmune diseases.Type: ApplicationFiled: March 5, 2001Publication date: November 7, 2002Applicant: THE WELLCOME FOUNDATION LIMITEDInventors: Jonathan Henry Ellis, Alan Peter Lewis
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Patent number: 5861179Abstract: The present invention relates to a pharmaceutical formulation of lamotrigine, pharmaceutically acceptable salts thereof and the preparation of such a formulation.Type: GrantFiled: June 26, 1997Date of Patent: January 19, 1999Assignee: The Wellcome Foundation LimitedInventors: Simon Philip Hiskett, Susan Ann Taylor
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Patent number: 5744466Abstract: Compounds of formula (I) ##STR1## wherein R and R.sup.1 are hydrogen, C.sub.1-4 alkyl or are linked to form a ring,A is a cycloalkyl or alkyl-cycloalkyl group,n is an integer from 0 to 3,W is an optionally substituted 5-or 6-membered heterocyclic ring; or W is an optionally substituted aryl, heteroaryl, aryloxy or thiophenoxy group; orW is a group --SO.sub.2 NR.sup.6 R.sup.7 --NHC(O)R.sup.6 R.sup.7 or --C(O)NHR.sup.6 R.sup.7 ;are useful in treating clinical conditions for which a "5-HT.sub.1 -like" receptor agonist is indicated.Type: GrantFiled: October 7, 1996Date of Patent: April 28, 1998Assignee: The Wellcome Foundation LimitedInventors: Robert Charles Glen, David Lawrence Selwood, Graeme Richard Martin, Christopher James Foster
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Patent number: 5717086Abstract: 2',3'-Dideoxy-3'-fluorouridines are made by reaction of a corresponding anhydronucleoside with hydrogen fluoride in the presence of an organo-iron compound.Type: GrantFiled: February 14, 1996Date of Patent: February 10, 1998Assignees: Rhone-Poulenc Chemicals Limited, The Wellcome Foundation LimitedInventors: Owen Ross Chambers, Patrick Charles Youmans, Andrew Lawrence Germain
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Patent number: 5527529Abstract: The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.Type: GrantFiled: April 10, 1995Date of Patent: June 18, 1996Assignees: The Wellcome Foundation Limited, The Royal Society, The Lister Institute of Preventive Medicine, The University Court of The University of DundeeInventors: Gordan Dougan, Steven N. Chatfield, Christopher F. Higgins, Charles J. Dorman
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Patent number: 5342616Abstract: The use of bolus injections of t-PA in the treatment of human beings with a thrombotic disorder.Type: GrantFiled: December 16, 1992Date of Patent: August 30, 1994Assignee: The Wellcome Foundation LimitedInventor: Adam F. Cohen
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Patent number: 5330977Abstract: The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ;n is 12 or 14;R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy.The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents and in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.Type: GrantFiled: July 27, 1992Date of Patent: July 19, 1994Assignee: The Wellcome Foundation LimitedInventors: Ezio Tubaro, Giovanni Cavallo
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Patent number: 5281702Abstract: The invention relates to N-deacetyl-lysogangliosides and physiologically acceptable salts thereof, especially those of formula (I): ##STR1## wherein R represents --CH.dbd.CH(CH.sub.2)nCH.sub.3 or --CH.sub.2 CH.sub.2 (CH.sub.2)nCH.sub.3 ;n is 12 or 14;R.sup.1 represents ##STR2## or hydrogen; and R.sup.2 represents hydrogen or acetyl; for use in therapy.The compounds are useful as inhibitors of phospholipases A.sub.2, and of superoxide production, as antiproliferative and immunosuppressant agents in the treatment of autoimmune diseases. The invention also relates to the use of N-deacetyl-lysogangliosides for the manufacture of medicaments for the treatment of the aforementioned conditions.Type: GrantFiled: June 18, 1991Date of Patent: January 25, 1994Assignee: Wellcome Foundation LimitedInventors: Ezio Tubaro, Giovanni Cavallo
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Patent number: 5229424Abstract: The present invention discloses pesticidally active compounds of formula (II) ##STR1## or a salt thereof, wherein Q is a monocylcic aromatic ring, or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each ring system being optionally substituted, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halogen or hydrogen; R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo, C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; and R.sup.1 is selected from hydrogen and C.sub.1-8 hydrocarbyl optionally substituted by dioxalanyl, halo, cyano, trifluoromethyl, trifluoromethylthio or C.sub.1-6 alkoxy and X.sup.1 is hydrogen, fluoro or chloro.Type: GrantFiled: February 14, 1992Date of Patent: July 20, 1993Assignee: The Wellcome Foundation LimitedInventors: Robert J. Blade, George S. Cockerill, John E. Robinson
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Patent number: 5202356Abstract: The present Application discloses pesticidally active compounds of the formula (I):Q Q.sup.1 CR.sup.2 =CR.sup.3 CR.sup.4 =CR.sup.5 C (.dbd.X) NHR.sup.1or a salt thereof, wherein Q is an monocyclic aromatic ring. or fused bicyclic ring system of which at least one ring is aromatic containing 9 or 10 atoms of which one may be nitrogen and the rest carbon each optionally substituted, or Q is a dihalovinyl group or a group R.sup.6 --C.tbd.C-- where R.sup.6 is C.sub.1-4 alkyl, tri C.sub.1-4 alkylsilyl, halogen or hydrogen; Q.sup.1 is a 1,2-cyclopropyl ring optionally substituted by one or more groups selected from C.sub.1-3 alkyl. halo, C.sub.1-3 haloalkyl, alkynyl, or cyano; R.sup.2,R.sup.3, R.sup.4 and R.sup.5 are the same or different with at least one being hydrogen and the others being independently selected from hydrogen, halo. C.sub.1-4 alkyl or C.sub.1-4 haloalkyl; X is oxygen or sulphur; and R.sup.1 is selected from hydrogen and C.sub.Type: GrantFiled: July 12, 1991Date of Patent: April 13, 1993Assignee: The Wellcome Foundation LimitedInventors: Robert J. Blade, George S. Cockerill, John E. Robinston
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Patent number: 5162367Abstract: Insecticidal and acaricidal compounds of FormulaAR(CH.sub.2).sub.x O(CH.sub.2).sub.m A(CH.sub.2).sub.n (CE.sup.1 =CE.sup.2).sub.a (CE.sup.3 =CE.sup.4)CONR.sup.1 R.sup.2 (I)whereinAr is phenyl or naphthyl, in either case optionally substituted by one or more of optionally substituted C.sub.1-6 alkyl, optionally substituted C.sub.1-6 -alkylthio or C.sub.1-6 alkylthiooxy, halogen or optionally substituted C.sub.1-6 alkoxy,x=0 or 1m=1 to 7n=1 to 7A=CH.sub.2 or oxygena=0 or 1R.sup.1 and R.sup.2 are independently selected from hydrogen, C.sub.1-6 alkyl and C.sub.3-6 cycloalkyl (either of which may be substituted by one or more of halo, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, CF.sub.2-6 alkoxy, C.sub.2-6 alkynyl, dioxalanyl and C.sub.3-6 cycloalkyl)E.sup.1, E.sup.2, E.sup.3 and E.sup.4 are independently selected from hydrogen, C.sub.1-4 alkyl, optionally substituted by halo, and nitrile, provided that at least one of E.sup.1, E.sup.2, E.sup.3 and E.sup.Type: GrantFiled: October 23, 1989Date of Patent: November 10, 1992Assignee: The Wellcome Foundation LimitedInventors: Robert J. Blade, John E. Robinson
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Patent number: 5150822Abstract: An apparatus for dispersing an active ingredient, such as a fumigant, fertilizer or room freshener in which the active ingredient is placed in a sample cylinder and a pressurized solvent/propellent is subsequently introduced from a source. The solvent/propellent expands to adopt a liquid phase and a gaseous phase. The liquid phase serves to absorb the active ingredient and the gaseous phase serves to propel the borne active ingredient out of the apparatus through a dispensing outlet where further expansion takes place and the active ingredient is dispersed in a fog or mist. Flow restrictors create a pressure differential between the sample cylinder outlet and a by-pass portion to enable total absorption of the active ingredient. The flow restrictors and conduits for the system are contained in a mixing head for the sample cylinder.Type: GrantFiled: January 30, 1991Date of Patent: September 29, 1992Assignee: The Wellcome Foundation LimitedInventors: Joseph G. Eitner, Jr., Robert J. Tice, Jr.
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Patent number: 5129566Abstract: An ampoule holder comprises a body part 1 and a head part 2 which are connected together by a pair of hinge strips 3 and a breakage link 4. A glass ampoule 7 is inserted, stem first, through an opening 6 in the base of the body portion 1. The body of the ampoule is forced past inwardly extending projections 8 until the lower end of the ampoule snaps past these projections and the shoulder at the top of the body of the ampoule 7 abuts against the curved hinge parts 3. The base of the ampoule will then be raised above the projections 8. The stem 10 of the ampoule is gripped within the head portion 2 of the holder by internal ribs or spines 11, so that the neck 9 of the ampoule is aligned with the breakage link 4.Type: GrantFiled: January 18, 1991Date of Patent: July 14, 1992Assignee: The Wellcome Foundation LimitedInventors: Brian L. Ogden, Christopher J. Griffin, Nicholas B. Verbelyi, Gerard M. O'Brien
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Patent number: 5116862Abstract: The present invention provides a class of novel substituted bicyclooctanes which have pesticidal activity, particularly against arthropod pests. Pesticidal formulations containing the compounds of the formula (I), their use in the control of pests and methods for their preparation are also disclosed.Type: GrantFiled: July 21, 1988Date of Patent: May 26, 1992Assignee: The Wellcome Foundation LimitedInventors: John B. Weston, John P. Larkin, Ian H. Smith
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Patent number: 5098929Abstract: A compound of the formula (I): ##STR1## wherein R is C.sub.2-10 alkyl, alkenyl or alkynyl, each optionally subsituted by or methyl substituted by cyano, C.sub.3-4 cycloalkyl, halo, C.sub.1-4 alkoxy or a group S(O)mR.sup.4 where R.sup.4 is C.sub.1-4 alkyl and m is O, 1 or 2, or R is C.sub.3-10 cycloalkyl, C.sub.4-10 cycloalkenyl or phenyl, each optionally substituted by C.sub.1-4 alkoxy, C.sub.1-3 alkyl, C.sub.2-4 alkynyl, halo, cyano or a group S(O)mR.sup.4 as defined hereinbefore; R.sup.1 is halo, C.sub.1-3 alkyl, C.sub.2-3 alkenyl or alkynyl each optionally substituted by halo, cyano, C.sub.1-4 alkoxy, alkyl carbalkoxy containing up to 6 carbon atoms, a group S(O)mR.sup.4 as defined hereinbefore or alkynyl substituted by tri-C.sub.1-4 alkylsilyl, or R.sup.1 is cyano, spiro-cyclopropyl, gem dimethyl, oxo or methylene optionally substituted by cyano or C.sub.1-3 alkyl optionally substituted by fluorine, or R.sup.1 and R and the carbon atoms to which they are attached form a C.sub.Type: GrantFiled: February 9, 1990Date of Patent: March 24, 1992Assignee: The Wellcome Foundation LimitedInventors: John P. Larkin, Ian H. Smith
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Patent number: 5057504Abstract: Pesticidal bicyclo-octanes are of the formula ##STR1## where R is a substituted or unsubstituted aliphatic or aromatic group, R' and R.sup.3 are H or a substituted or unsubstituted aliphatic or aromatic group, R.sup.2 is a substituted or unsubstituted heterocyclic group containing at least one ring nitrogen and is preferably a 3- or 4- pyridyl group, Z is CH.sub.2 CH.sub.2, CH.sub.2 O--CH.sub.2 S or COCH.sub.2 or CH(OR.sup.5)CH.sub.2 where R.sup.5 is H, alkyl, acyl or carbamoyl at Y and Y' are O or S(O).sub.m where m is 0, 1 or 2.Various methods for their preparation are described.Type: GrantFiled: August 16, 1989Date of Patent: October 15, 1991Assignee: The Wellcome Foundation LimitedInventors: Malcolm H. Black, John A. Wyatt, John B. Weston, John P. Larkin, Ian H. Smith, David A. Pulman
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Patent number: 5026874Abstract: The present invention provides compounds of the formula (I): ##STR1## wherein R is a C.sub.2-10 non-aromatic hydrocarbyl group, a C.sub.2-10 non-aromatic hydrocarbyl group substituted by, or methyl substituted by cyano, halo, C.sub.1-4 alkoxy, C.sub.1-4 alkoxy substituted by halo, or a group S(O).sub.m R.sup.4 where R.sup.4 is C.sub.1-4 alkyl optionally substituted by halo and m is 0, 1 or 2, or R is phenyl or phenyl substituted by C.sub.1-4 alkoxy, C.sub.1-3 alkyl, C.sub.2-4 alkynyl, halo, C.sub.1-4 haloalkyl, cyano or a group S(O).sub.m R.sup.4 as defined hereinbefore;R.sup.1 and R.sup.2 may be the same or different, and each is hydrogen, or a C.sub.1-3 aliphatic group, or a C.sub.1-3 aliphatic group substituted by halo; R.sup.3 contains between 3 and 18 carbon atoms and is a group R.sup.5 wherein R.sup.5 is a C.sub.1-13 non-aromatic hydrocarbyl group, a C.sub.1-3 non-aromatic hydrocarbyl group substituted by a C.sub.Type: GrantFiled: December 14, 1989Date of Patent: June 25, 1991Assignee: Wellcome Foundation LimitedInventors: John P. Larkin, John A. Wyatt, Deborah J. Hawkes
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Patent number: 5020689Abstract: The invention is concerned with a method and apparatus for dispersing an active ingredient, such as a fumigant. The active ingredient is placed in a container and a pressurized solvent/propellent is subsequently introduced. The solvent/propellent expands to adopt a liquid phase and a gaseous phase. The liquid phase serves to absorb the active ingredient and the gaseous phase serves to propel the borne active ingredient out of the apparatus where further expansion takes place and the active ingredient is dispersed in a fog or mist.Type: GrantFiled: October 27, 1989Date of Patent: June 4, 1991Assignee: The Wellcome Foundation LimitedInventors: Joseph G. Eitner, Jr., Robert J. Tice, Jr.
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Patent number: 4997239Abstract: A towel-dispensing cabinet has a loop of towel web (1) available for a user, a substantial part (12) of the loop being removably contained within the cabinet. The length of exposed web (between C and D) can be increased by a user drawing web material from the concealed loop part (12) against the urging of a gravity-urged roller (9).Type: GrantFiled: February 16, 1990Date of Patent: March 5, 1991Assignee: The Wellcome Foundation LimitedInventors: David J. Crisp, Clive A. Roux
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Patent number: D340519Type: GrantFiled: April 2, 1991Date of Patent: October 19, 1993Assignee: The Wellcome Foundation LimitedInventors: Brian L. Ogden, Christopher J. Griffin, Nicholas B. Verebelyi, Gerard M. O'Brian