Abstract: Applicator assembly comprising a container for liquids having a bottom wall member, a cap member having means for detachably securing it over a discharge opening in the container. An upstanding wall and a bottom wall having an upstanding post member having an opening communicating with the interior of the container define a measuring chamber for a predetermined measured quantity of the liquid with a cylindrical wall portion of the cap member. An elongated tubular member is mounted in the opening in the post member extending downwardly into the container adjacent the lowest portion of the bottom wall member. A valve seat plate member is mounted at the open end of the cylindrical wall portion and has a wall portion terminating in a valve opening which is tapered towards the valve opening and functions as a funnel during discharge of contents to ensure complete transfer from the measuring chamber to a dispensing chamber above the measuring chamber.

Abstract: A container cap, comprising a cap body having an annular shoulder with an inner and outer terminal edge. The shoulder has a skirt depending from the outer terminal edge of the shoulder and an upper cylinder is attached to the annular shoulder at its inner terminal edge. The cylinder extends upward, terminating in an annular flared lip and the upper cylinder is attached to the shoulder by an annular scoring ring.

Abstract: A thermoplastic elastomeric block copolymer having terminal polystyrene units and olefin elastomeric mid block units, the copolymer having at least a glass transition temperature increasing amount of naphthoylated substitution on the polystyrene units.

Abstract: A combination of a cap and tube in which a tube has an opening terminating in a tapered nozzle with an open end. The nozzle has a first diameter proximate said tube and is designed for rotational engagement with a cap. The nozzle includes a ring with a diameter which is the largest diameter of the nozzle and is located at least a band width distance from the junction of the nozzle to the tube. The cap is sized to engage the nozzle at its open end and has a closed outer terminal end. The outer end of the cap includes an axially centered locating cup for engagement with the outer open end of the nozzle. This forms a first seal in a first position and a second seal in a second position which is closer to the outer cap end by the band width distance. The cap is designed for rotational engagement with the nozzle. At its nozzle engaging end, the cap terminates with a circumferential band having an axial width defining the above mentioned band width distance.

Abstract: A cap assembly for use with a container having a stopper and a closure including a cap defining a chamber above a stopper. The cap on said closure, said cap including an access disc penetrable by a syringe position in alignment with the stopper for access to the container by the syringe. The assembly further including vent ports for communication between the chamber and the atmosphere. Finally there is a filter in the chamber for filtering gas flow through the vent port.

Abstract: A method of making a thermoplastic elastomer composition produced by dynamic vulcanization of SBR as a dispersed phase of cross linked SBR, and a co-continuous matrix of SEBS and polypropylene. The dynamic vulcanization step takes place under conditions of shear and temperature to reach the decomposition point of crosslinked SBR, at which time the crosslinking reaction is quenched. Compositions of superior properties are achieved using this method.

Abstract: A lyophilization container device comprising a top end having at least one lyophilization port axially extending upward and defining a generally polygonally oval shape. The device includes a bottom end having generally the same shape as the top and having preferably a substantially flat bottom. Also included is a wall portion sealed to the top and bottom end to define the container, with the wall portion having an inside surface which is drug compatible and has sufficient buckle strength to withstand vertical force during stopper seating.

Abstract: A closure device for use with a container, comprising cap means with a pull tab and scoring to remove the cap, the scoring including stepped scoring on both sides of the cap with each scoring having a frangible interruption proximate the top radial edge of the cap.

Abstract: A device for use with containers, including an elastomeric member sized to engage the container. The member has a first portion for contact with the container to form a seal and a second portion having a polyparaxylylene coating to form a barrier between the member and the contents of the container.

Abstract: Orienting apparatus for orienting articles such as stoppers in a predtermined fashion so that they can be assembled to vials comprising a central rotatable dome member, defining an open chamber for the stoppers where they are positioned in random fashion and a plurality of track-ways communicating with the rotatable dome element and a discharge station and deflector means along the track-ways cooperatively associated therewith which, upon rotation of the dome element, cause the element along said track-ways and during course of movement to become oriented in a predetermined position when they are at the said discharge station.

Abstract: Apparatus for sterilizing objects, including an enclosed chamber having an inlet and an outlet. Also included are walls defining and separately enclosing a preheat zone, a sterilization zone and cooling zone respectively between the inlet and the outlet. The preheat zone includes an exhaust stack for discharging air from the apparatus. The exhaust unit has a temperature sensor for adjusting the amount of exhaust air based upon the temperature in the exhaust stack. The cooling zone includes a recirculating device for directing air from the cooling zone to the preheat zone. It also includes a regulator to control the amount of air directed by the recirculating device, based upon air pressure in the cooling zone.

Abstract: An elastomeric member for use with a container and in contact with pharmaceutically pure contents therein. The elastomeric member has an elastomeric base and a continuous polyparaxylylene coating on the base. The coating ranges from about 0.1 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.0 and is capable of substantially preventing metal extraction from said elastomers.

Abstract: A thermoplastic elastomer composition is possible which has low coefficient friction, reduced stickiness and good structural integrity. A halobutyl rubber is cured by dynamic vulcanization in the presence of sufficient thermoplastic material to function as a continuous phase for the vulcanization. Thereafter, up to 25 parts based on 100 parts of the rubber of an uncured organopolysiloxane grafted EPDM polymer are admixed to form the final moldable product, resulting in a mixture which has good structural integrity and a smooth finished surface.

Abstract: An elastomeric member for use with a container and in contact with pharmaceutically pure contents therein. The elastomeric member has an elastomeric base and a continuous polyparaxylylene coating on the base. The coating ranges from about 0.5 microns to about 2.0 microns in thickness. The closure member has a coefficient of friction of less than 1.0 and is capable of substantially preventing metal extraction from said elastomers.

Abstract: A device for transferring small discrete objects such as pharmaceutical stoppers and caps including a frame movably positionable at a predetermined location for delivery of the objects and an angularly displaced conveyor on the frame having a discharge chute at the predetermined location for discharge of objects thereto. The conveyor includes a conveyor chain defining a path from a transfer path to the discharge chute. The chain has bucket flights for conveying the objects along the path. A delivery chute is also on the frame for transferring the objects to the transfer point. The delivery chute includes a first tray inclined with the horizontal and having an open terminal end adjacent the transfer point positioned to feed the objects to the conveyor chain. The delivery chute further includes a second tray located within the first tray at the same or greater angle with the horizontal and positioned to receive the objects.

Abstract: A thermoplastic elastomer composition produced by dynamic vulcanization of SBR has a dispersed phase of cross linked SBR, and a co-continuous matrix of SEBS and polypropylene.

Abstract: A stopper device for use on a pharmaceutical closure, comprising an elastomeric stopper sized to function as a closure; and a polyurethane coating on the stopper. The coating has a modulus sufficient to decrease the coefficient of friction of the stopper to less than 0.6.

Abstract: A syringe assembly comprising a casing for a medicament or the like having a discharge opening at one end, a diaphragm assembly mounted at said end normally sealing said contents, plunger means movable in said casing and operable upon displacement in one direction to effect increase in pressure in said casing to rupture or displace said diaphragm to permit discharge of the contents of said casing.