Patents Assigned to The Wistar Institute
  • Patent number: 12290561
    Abstract: Provided herein are non-naturally occurring variants of the hepatitis B virus (HBV) Core protein, the HBV polymerase N-terminal domain, and the HBV polymerase C-terminal domain, as well as immunogenic fragments thereof. Fusion proteins comprising the HBV variants fused to a herpes simplex virus (HSV) glycoprotein (gD) sequence, as well as methods of using the fusion proteins, are also provided.
    Type: Grant
    Filed: October 24, 2023
    Date of Patent: May 6, 2025
    Assignees: Virion Therapeutics, LLC, The Wistar Institute
    Inventors: Hildegund C J Ertl, Colin Stephen Magowan
  • Patent number: 12281084
    Abstract: The present disclosure provides compounds, which in certain embodiments are ACSS2 inhibitors. In certain embodiments, the compounds of the disclosure are useful for treating, ameliorating, and/or preventing certain types of cancer.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: April 22, 2025
    Assignee: The Wistar Institute
    Inventors: Zachary Schug, Joseph Salvino, Valli Venkata Srikanth Yellamelli
  • Patent number: 12268735
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Marburgvirus filovirus glycoprotein immunogens. Immunomodulatory methods and methods of inducing an immune response against Marburgvirus are disclosed. Method of preventing infection by Marburgvirus and methods of treating individuals infected with Marburgvirus are disclosed. Consensus Marburgvirus filovirus glycoprotein immunogens are disclosed.
    Type: Grant
    Filed: March 7, 2023
    Date of Patent: April 8, 2025
    Assignees: The Wistar Institute of Anatomy and Biology, The Trustees of the University of Pennsylvania
    Inventors: David Weiner, Ami Patel, Sarah Elliott
  • Publication number: 20250110117
    Abstract: The disclosure provides materials and methods for permanently labeling cells by transducing cells with viruses comprising a barcode. The disclosure is based on the idea that tracking, selecting and isolating lymphocytes labeled with the barcode can facilitate identification of clonal cells responsible for antibody or antibody fragment production.
    Type: Application
    Filed: September 30, 2024
    Publication date: April 3, 2025
    Applicant: The Wistar Institute of Anatomy and Biology
    Inventor: Amelia ESCOLANO
  • Patent number: 12258314
    Abstract: Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: March 25, 2025
    Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: Troy E. Messick, Garry R. Smith, Allen B. Reitz, Paul M. Lieberman, Mark E. McDONNELL, Yan Zhang, Venkata Velvadapu
  • Publication number: 20250092029
    Abstract: Disclosed herein are compounds of the formulas (I) as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit Mpro proteases. Also provided are methods of administering compounds and compositions provided herein to a patient in need thereof, for example, for the treatment of diseases such as SARS-CoV-2 or a variant thereof.
    Type: Application
    Filed: February 7, 2023
    Publication date: March 20, 2025
    Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: Joseph SALVINO, Luis MONTANER, Ian TIETJEN, Adi NARAYANA REDDY POLI
  • Publication number: 20250092035
    Abstract: The present disclosure provides compounds of the formula: wherein the variables are defined herein, as well as pharmaceutical compositions thereof. The present disclosure also provides methods of inhibiting isocitrate dehydrogenase 1 (IDH1) and methods of treating or preventing a disease or disorder using said compounds and/or compositions.
    Type: Application
    Filed: January 25, 2023
    Publication date: March 20, 2025
    Applicants: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY, UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER, CASE WESTERN RESERVE UNIVERSITY
    Inventors: Joseph SALVINO, Farheen MOHAMMED, Joel CASSEL, Valli YELLAMELLI, Jordan M. WINTER
  • Patent number: 12240872
    Abstract: Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus Ebolavirus glycoproteinimmunogens are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against Ebolavirus are disclosed. Method of preventing Ebolavirus and methods of treating individuals infected with Ebolavirus are disclosed. Consensus Ebolavirus proteins are disclosed.
    Type: Grant
    Filed: August 17, 2021
    Date of Patent: March 4, 2025
    Assignees: The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David B. Weiner, Ami Patel, Jian Yan
  • Patent number: 12194000
    Abstract: Provided herein is an immunogenic composition comprising a synthetic consensus antigen to chondroitin sulfate proteoglycan 4 (CSPG4) protein which is abundant in many cancers. Also disclosed herein is a method of treating a tumor associated pathology in a subject in need thereof, by administering the immunogenic composition to the subject.
    Type: Grant
    Filed: August 1, 2019
    Date of Patent: January 14, 2025
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventor: David Weiner
  • Patent number: 12194086
    Abstract: Disclosed herein is a composition comprising a nucleic acid sequence encoding a Mayaro Virus antigen that elicits an immune response in a mammal. Also disclosed herein is a nucleic acid sequence encoding an anti-Mayaro Virus antibody, a fragment thereof, a variant thereof. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating a Mayaro virus infection in a subject using said composition and method of generation.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: January 14, 2025
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: David B. Weiner, Kar Muthumani, Sagar Kudchodkar
  • Patent number: 12195536
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets CTLA-4. The disclosure also provides a method of preventing and/or treating disease, such as cancer, in a subject using the composition of the invention.
    Type: Grant
    Filed: October 3, 2018
    Date of Patent: January 14, 2025
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Elizabeth Duperret
  • Patent number: 12162925
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to an Ebola viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Ebola virus infection in a subject using said composition and method of generation.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: December 10, 2024
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Ami Patel
  • Patent number: 12146156
    Abstract: Provided herein are methods of generating MDSCs ex vivo. The methods include culturing blood cells with an LRP2 agonist.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: November 19, 2024
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventor: Dmitry I. Gabrilovich
  • Patent number: 12116359
    Abstract: The invention relates, in certain aspects, to developable forms of certain compounds that are useful to treat and/or prevent EBV infection and related conditions in a subject. The invention further provides EBNA1 inhibitors, and/or pharmaceutical compositions comprising the same, that are useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection and/or lytic EBV infection.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: October 15, 2024
    Assignee: The Wistar Institute
    Inventors: Troy E. Messick, Paul M. Lieberman, Garry R. Smith, Arlindo L. Castelhano
  • Patent number: 12110342
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody or fragment thereof that targets PCSK9. The disclosure also provides a method of preventing and/or treating disease, such as cardiovascular disease or hypercholesterolemia, in a subject using the composition of the invention.
    Type: Grant
    Filed: January 31, 2019
    Date of Patent: October 8, 2024
    Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: David Weiner, Makan Khoshnejad, Kar Muthumani, Ami Patel
  • Patent number: 12109258
    Abstract: Provided herein are sequences of Plasmodium spp. liver stage exported proteins as well as expression constructs expressing the sequences. Also provided herein are methods for generating an immune response against malaria using the expression constructs provided herein.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: October 8, 2024
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Emma Reuschel, Bernadette Ferraro, Ahmed S. I. Aly
  • Patent number: 12054537
    Abstract: Disclosed herein are compositions comprising structurally modified DNA encoded antibodies (DMAbs), methods of structurally modifying DMAbs, and methods of using structurally modified DMAbs.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: August 6, 2024
    Assignees: The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Ghiabe Guibinga, Neil Cooch, Charles Reed
  • Patent number: 11981724
    Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Middle East Respiratory Syncytial Coronavirus (MERS-CoV) viral antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an MERS-CoV virus infection in a subject using said composition and method of generation.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: May 14, 2024
    Assignees: The Wistar Institute of Anatomy and Biology, Inovio Pharmaceuticals, Inc.
    Inventors: David Weiner, Trevor R F Smith, Kar Muthumani
  • Patent number: 11945851
    Abstract: Disclosed herein are compositions and methods for treating and/or preventing cancer in mammals, and in particular, vaccines that treat and provide protection against tumor growth.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: April 2, 2024
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Elizabeth Duperret
  • Patent number: 11925685
    Abstract: Disclosed herein is a composition comprising a recombinant nucleic acid sequence that encodes an antibody to a Zika viral antigen, and functional fragments thereof. The invention also relates to a composition comprising the combination of a first composition that elicits an immune response in a mammal against zika virus and a second composition comprising a recombinant nucleic acid sequence encoding an antibody, a fragment thereof, a variant thereof, or a combination thereof. In some instances, the nucleic acid molecule comprises a nucleotide sequence encoding an anti-ZIKV-Envelope (anti-ZIKV E) Protein antibody.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 12, 2024
    Assignees: The Trustees of the University of Pennsylvania, Inovio Pharmaceuticals, Inc., The Wistar Institute of Anatomy and Biology
    Inventors: David Weiner, Karuppiah Muthumani, Jian Yan