Abstract: The present invention provides Bin2 sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of blood disorders, including hepatocarcinoma. Further provided are oligonucleotides derived from sequences encoding Bin2, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
Type:
Application
Filed:
October 29, 2004
Publication date:
September 29, 2005
Applicant:
The Wistar Institute of Anatomy and Biology
Abstract: Compositions containing one or more peptido-mimetics or modified peptido-mimetics of a carbohydrate ligand of an adhesion molecule in a physiologically acceptable carrier are useful for methods of reducing metastasis in a mammal and for inhibiting inflammatory response in a mammal. Particularly useful are embodiments in which the ligand is a Lewis antigen and/or the adhesion molecule is a selectin, e.g., E-selectin. Methods are disclosed for identifying peptido-mimetics of carbohydrate ligands, which may be involved in binding of tumor cells to other cells, such as endothelial cells.
Type:
Application
Filed:
March 16, 2005
Publication date:
August 18, 2005
Applicants:
The Wistar Institute of Anatomy and Biology, The Trustees of the University of Pennsylvania
Inventors:
Magdalena Blaszczyk-Thurin, Thomas Kieber-Emmons
Abstract: The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples where reproducible resolution and quantitation of greater than 10,000 protein components is feasible.
Abstract: Levels of thyroid hormone can be decreased in a mammal to increase healing of heart wounds. The increased wound healing includes rapid re-epithelialization and recovery of normal architecture and function relative to mammals who have not been treated according to the invention.
Abstract: Pharmaceutical compositions comprising the HIV protein vpr or nucleic acid molecule encoding vpr are disclosed. Also disclosed are methods of treating patients suffering from diseases characterized by hyperproliferating undifferentiated cells such as cancer by administering such compositions. Methods of identifying compounds which have anti-HIV activity are disclosed, in particular, methods of identifying compounds which modulate the activity of vpr and of identifying compounds which inhibit vpr binding to the HIV protein gag.
Type:
Grant
Filed:
December 15, 1993
Date of Patent:
January 4, 2005
Assignees:
The Trustees of the University of Pennsylvania, The Wistar Institute
Inventors:
David B. Weiner, David Nathan Levy, Yosef Refaeli
Abstract: The present invention provides Bin2 sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of blood disorders, including hepatocarcinoma. Further provided are oligonucleotides derived from sequences encoding Bin2, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
Type:
Grant
Filed:
February 25, 2002
Date of Patent:
December 14, 2004
Assignee:
The Wistar Institute of Anatomy and Biology
Abstract: TALL-104 cells, and other cytotoxic T cell lines, may be modified to increase the cytotoxicity thereof, to enhance growth properties, and/or to provide a preferred phenotype, e.g., expression of cell surface antigens, function, e.g., change in cytokine production profile, by culturing the cells in an effective amount of IL-15, optionally followed by gamma irradiation to halt proliferation.
Type:
Grant
Filed:
August 21, 2001
Date of Patent:
December 7, 2004
Assignee:
The Wistar Institute of Anatomy and Biology
Inventors:
Daniela Santoli, Giovanni Rovera, Alessandra Cesano
Abstract: Methods for treating cancer in a mammalian patient having cancer and a functional immune system, and for preventing recurrences of cancer following completion of cancer therapy, are described. The methods involve administration of a course of therapy with modified TALL-104 cells, without requiring the co-administration of an immunosuppressive agent.
Type:
Grant
Filed:
June 20, 1997
Date of Patent:
April 6, 2004
Assignee:
The Wistar Institute of Anatomy and Biology
Inventors:
Daniela Santoli, Giovanni Rovera, Alessandra Cesano
Abstract: This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
Type:
Application
Filed:
February 5, 2003
Publication date:
March 4, 2004
Applicant:
Wyeth and The Wistar Institute
Inventors:
Giorgio Trinchieri, Bice Perussia, Stanley F. Wolf, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi
Abstract: Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for treating wounds, including central and peripheral nerve wounds, are also provided.
Abstract: A method of reducing immune response during gene therapy is provided which involves co-administration of the viral vector bearing a therapeutic transgene and a selected immune modulator capable of inhibiting the formation of neutralizing antibodies and/or CTL elimination of the vectors upon repeated administration.
Type:
Application
Filed:
November 27, 2001
Publication date:
November 27, 2003
Applicants:
The Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology
Inventors:
James M. Wilson, Yiping Yang, Giorgio Trinchieri
Abstract: The present invention describes novel soluble variants of type I membrane protein GA733-2 and methods of making and using them. In addition, the present invention describes a method of converting type I membrane proteins into secretory proteins which may be used for active immunotherapy against carcinomas and as reagents in the detection of GA733-2 expression on tumor cells.
Type:
Grant
Filed:
March 30, 1995
Date of Patent:
November 11, 2003
Assignee:
The Wistar Institute of Anatomy and Biology
Inventors:
Alban J. Linnenbach, Hilary Koprowski, Dorothee Herlyn
Abstract: The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples where reproducible resolution and quantitation of greater than 10,000 protein components is feasible.
Abstract: The invention provides a novel solution isoelectric focusing device and method that can reproducibly fractionate charged molecules into well-defined pools. This approach can be applied to mixtures of charged molecules, such as eukaryotic proteome samples where reproducible resolution and quantitation of greater than 10,000 protein components is feasible.
Abstract: The present invention provides Bin1 genomic sequences and proteins encoded thereby. Also provided are compositions and methods utilizing these sequences and proteins in the diagnosis and treatment of cancers and hyperplastic disease states. Further provided are oligonucleotides derived from sequences encoding Bin1, as well as compositions and methods utilizing same for diagnostic and therapeutic purposes.
Type:
Application
Filed:
April 16, 2002
Publication date:
September 4, 2003
Applicant:
The Wistar Institute of Anatomy and Biology
Inventors:
George C. Prendergast, Daitoku Sakamuro
Abstract: A method for identifying a compound that has a biocidal effect against a selected organism involves screening from among known or unknown peptide or non-peptide molecules, a test molecule that binds selectively to a target sequence of a multi-helical lid of a heat shock protein of the organism. The binding of the test compound inhibits the protein folding activity of the protein. A specific embodiment of such a method is useful for identifying or designing a pharmaceutical or veterinary biocidal or antibiotic compound, preferably a pathogen and/or strain-specific compound. For this purpose, the compound does not bind to a heat shock protein that is homologous to the mammalian subject to be treated with the compound. Screening methods can encompass direct binding or competitive assays. Molecules or compounds identified by these methods are employed as biocides for pharmaceutical, veterinary, pesticide, insecticide and rodenticide uses, among others.
Type:
Application
Filed:
July 19, 2002
Publication date:
June 12, 2003
Applicant:
The Wistar Institute of Anatomy and Biology
Abstract: The present invention describes novel soluble variants of type I membrane protein GA733-2 and methods of making and using them. In addition, the present invention describes a method of converting type I membrane proteins into secretory proteins which may be used for active immunotherapy against carcinomas and as reagents in the detection of GA733-2 expression on tumor cells.
Type:
Application
Filed:
November 19, 2002
Publication date:
June 5, 2003
Applicant:
The Wistar Institute of Anatomy and Biology
Inventors:
Alban J. Linnenbach, Hilary Koprowski, Dorothee Herlyn
Abstract: A method for reducing atherosclerotic plaques includes administering an effective amount of at least one fatty acid composition to an animal, said fatty acid composition having a carbon chain of at least 16 carbons in length, and wherein at least one pair of double bonds are in a conjugated position. Such a method and article of manufactures facilitating these methods may be useful for reducing atherosclerotic plaques in humans.
Abstract: This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.
Type:
Grant
Filed:
August 9, 2001
Date of Patent:
April 29, 2003
Assignees:
Wyeth, The Wistar Institute
Inventors:
Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi
Abstract: Mice in which enhance wound healing occurs can be used to identify genes and gene products which are involved in enhanced wound healing in mammals, including humans. Methods and compositions for treating wounds, including central and peripheral nerve wounds, are also provided.