Abstract: A method for increasing the blood flow and metabolic rate of the eye fundus by (1) irradiating the eye fundus through the pupil by using red light or near-infrared light in a certain wavelength range, a certain energy density range and a certain irradiation time range; (2) once irradiation is complete, repeating the irradiating at intervals of a certain time range, using red light or near-infrared light in the same wavelength range and the same energy density range to irradiate the eye fundus through the pupil.

Abstract: A method for increasing the blood flow and metabolic rate of the eye fundus by (1) irradiating the eye fundus through the pupil by using red light or near-infrared light in a certain wavelength range, a certain energy density range and a certain irradiation time range; (2) once irradiation is complete, repeating the irradiating at intervals of a certain time range, using red light or near-infrared light in the same wavelength range and the same energy density range to irradiate the eye fundus through the pupil.

Abstract: Provided is a method of serum-free culturing corneal limbal stromal stem cells and inducing them to differentiate and form spheres. Also provide is a medium combination for inducing corneal limbal stromal stem cells to form spheres or differentiate into corneal limbal stromal cells in vitro. The serum-free medium combination used herein can provide sufficient nutrients and a good environment required for cell growth and proliferation, can provide a stable in vitro expansion of corneal limbal stromal stem cells and can ensure that the expanded corneal limbal stromal stem cells keep their stemness and specificity. In addition, a system for inducing them to differentiate into corneal limbal stromal cells is successfully built. It can be used in experimental studies of corneal limbal stromal stem cells, cell therapy of corneal lesions and transplant for corneal injury.

Abstract: The invention relates to an artificial intelligence cataract analysis system, including a pattern recognition module for recognizing a photo mode of an input eye image, wherein the photo mode is divided according to the slit width of the illuminating slit during photographing of the eye image and/or whether a mydriatic treatment is carried out; a preliminary analysis module used for selecting a corresponding deep learning model for eye different photo modes, analyzing the characteristics of lens in the eye image by using a deep learning model, and further performing classification in combination with cause and severity degree of a disease. The invention can perform cataract intelligent analysis on eye images with different photo modes by using deep learning models, so that the analysis accuracy is improved.

Abstract: Collection devices with valves for liquid specimens are disclosed. In an embodiment, the disclosure provides a collection device including a reservoir having a sealed cavity, the sealed cavity being under a negative pressure; a delivery tube in communication with the sealed cavity of the reservoir and having a delivery inlet, a delivery outlet, and a valve disposed between the delivery inlet and the delivery outlet, the valve being configured to control the communication and blocking between the delivery inlet and the delivery outlet, and an angle being formed by an extension line of the delivery inlet an extension line of the delivery outlet; and a piercing component for piercing a tissue is connected with the delivery inlet of the delivery tube.

Abstract: Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treating cataracts. The lanosterol prodrug compound has a better permeability than lanosterol.

Abstract: Preparation and expansion methods for human pluripotent stem cell-derived human retinal pigment epithelial cells are provided. The preparation method includes the following steps: collecting 3D-PRE spheroids derived from human pluripotent stem cells, performing mechanical separation to remove non-RPE cells and clusters which are non-pigmented and retain a pigmented RPE cell sheet, enzymatically digesting the pigmented RPE cell sheet to obtain an RPE single cell suspension, and thereby the human pluripotent stem cell-derived human retinal pigment epithelial cells are obtained. The expansion method includes centrifuging the RPE single cell suspension and removing a supernatant, resuspending in an RPE cell medium and seeding into a cell culture container precoated with extracellular matrix to allow primary culture, and subculturing the cells after cells spread out.

Abstract: A serum-free culture medium for limbal stem cells and a culture method thereof, wherein the serum-free culture medium includes a basic medium and supplements; wherein the supplements include: human recombinant EGF, insulin, 3,3?,5-triiodo-L-thyronine, hydrocortisone, forskolin, manganese sulfate monohydrate, sodium selenite, sodium metasilicate, ammonium metavanadate, nickel chloride hexahydrate, stannous chloride dihydrate, ethanolamine, O-phosphorylethanolamine, ammonium molybdate tetrahydrate, 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid, vitamin C, bovine serum albumin, lipid concentrate and serum substitute.

Abstract: Disclosed are a lanosterol prodrug compound, a pharmaceutically acceptable salt and an isomer thereof, and a pharmaceutical composition comprising the lanosterol prodrug compound and the use thereof in the preparation of a drug for treating cataracts. The lanosterol prodrug compound has a better permeability than lanosterol.

Abstract: Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.

Abstract: A transformable bed for examinations in pediatric ophthalmology, especially suitable for the use of general anesthesia when conducting eye examinations, is provided. The bed may include a fixed bed board, a movable bed board, a movable seat, a movable support, a securing strap, and a main frame. The bed may be fixedly connected to the top of the main frame, the movable bed board may be rotationally connected to the top of the main frame, and the movable seat may be rotationally connected to the top of the main frame. The securing strap may be disposed on the movable bed board, in which one end of the movable support may be removably connected to the movable bed board, and another end may be removably connected to the main frame. The transformable bed may function both as an anesthesia bed and a handcart, and may be quickly switched therebetween.

Abstract: A transformable bed for examinations in pediatric ophthalmology, especially suitable for the use of general anesthesia when conducting eye examinations, is provided. The bed may include a fixed bed board, a movable bed board, a movable seat, a movable support, a securing strap, and a main frame. The bed may be fixedly connected to the top of the main frame, the movable bed board may be rotationally connected to the top of the main frame, and the movable seat may be rotationally connected to the top of the main frame. The securing strap may be disposed on the movable bed board, in which one end of the movable support may be removably connected to the movable bed board, and another end may be removably connected to the main frame. The transformable bed may function both as an anesthesia bed and a handcart, and may be quickly switched therebetween.

Abstract: A pharmaceutical composition for the treatment of immune-related diseases of ocular surface and the anterior segment of the eye. More specifically, the invention relates to a composition comprising tacrolimus in a pharmaceutically acceptable formulation, particularly a suitable local treatment formulation, such as eye drops and ointments. Also disclosed is a method for the treatment of immune-response related ocular diseases of the anterior segment of the eye and the eye surface, wherein the method comprises administering to a patient in need thereof the pharmaceutical composition of the present invention. The method of the present invention preferably further comprises administering to the patient an immunosuppressant in addition to tacrolimus.