Abstract: The invention features soluble FGF decoy polypeptides and fusion polypeptides comprising an FGF decoy polypeptide linked to a heterologous polypeptide, such as an aggrecan binding protein. Both soluble FGF decoy polypeptides and fusion polypeptides can be used to prevent or treat skeletal disorders, such as achondroplasia.
Type:
Application
Filed:
January 7, 2016
Publication date:
May 31, 2018
Applicants:
TheAchon, Inserm (Institut National de la Sante et de la Recherche Medicale), Universite Nice Sophia Antipolis