Abstract: Compositions for stabilizing and delivering proteins and/or other bioactive agents are disclosed. The bioactive agents are embedded or encapsulated in a crystalline matrix. Typically the bioactive agents are in the form of micro- or nanoparticles. The crystalline matrix confers enhanced stability to the agents embedded therein relative to other microparticulate or nanoparticulate bioactive agents. The carriers are especially useful for stabilizing bioactive macromolecules, such as proteins.
Type:
Grant
Filed:
June 23, 2020
Date of Patent:
November 22, 2022
Assignees:
BROWN UNIVERSITY, THEBAPYX, INC.
Inventors:
Edith Mathiowitz, Stacia Furtado, Nejat Egilmez, Thomas Conway