Patents Assigned to Theodor Kocher Institut
  • Neutrophil-activating factor
    Patent number: 6383479
    Abstract: Biologically active, pure neutrophil-activating factor (NAF) isolated from human monocytes or after expression of a synthetic NAF gene in E.coli and having the following amino acid sequence Ser-Ala-Lys-Glu-Leu-Arg-Cys-Gln-Cys-Ile-Lys-Thr-Tyr-Ser-Lys-Pro-Phe-His-Pro-Lys-Phe-Ile-Lys-Glu-Leu-Arg-Val-Ile-Glu-Ser-Gly-Pro-His-Cys-Ala-Asn-Thr-Glu-Ile-Ile-Val-Lys-Leu-Ser-Asp-Gly-Arg-Glu-Leu-Cys-Leu-Asp-Pro-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-ArgAla-Glu-Asn-Ser.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 7, 2002
    Assignees: Novartis AG, Theodor Kocher Institut
    Inventors: Heinrich Aschauer, Ivan James Daldon Lindley, Paola Peveri, Alfred Walz
  • Neutrophil-activating peptide-2
    Patent number: 5759533
    Abstract: Peptides having the amino acid sequence ##STR1## wherein X is H, Asp-Leu-Tyr-, Ser-Asp-Leu-Tyr- or Asp-Ser-Asp-Leu-Tyr-. The peptide wherein X is H is human neutrophil-activating peptide-2 (hNAP-2) and those wherein X is other than H are natural variants thereof. The peptides have neutrophil-stimulating activity, are structurally related to NAF/NAP-1, .beta.-thromboglobulin, PBP and CTAP-III and may be isolated from leukocytes and platelets and synthesized by standard peptide synthesis processes and recombinant DNA techniques.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 2, 1998
    Assignees: Novartis AG, Theodor Kocher Institut
    Inventors: Marco Baggiolini, Kenneth John Clemetson, Alfred Walz