Patents Assigned to THEORIA SCIENCE INC.
  • Publication number: 20190185851
    Abstract: An exosome secretion inhibitor containing a substance suppressing expression of NAPG, HINT3 or GXYLT1 gene, or a substance suppressing activity of NAPG, HINT3 or GXYLT1 protein. It is possible to suppress secretion of exosome, thereby making it possible to suppress proliferation or metastasis of cancer cells, so that the substance suppressing expression of the gene or activity of the protein can be used as an active ingredient of a pharmaceutical composition suitably used in treatment of cancer or suppression of cancer metastasis, and also the substance can provide a carcinostatic agent having a new action mechanism which specifically suppresses expression of the gene or activity of the protein.
    Type: Application
    Filed: August 30, 2016
    Publication date: June 20, 2019
    Applicant: THEORIA SCIENCE INC.
    Inventors: Takahiro OCHIYA, Yusuke YOSHIOKA, Nobuyoshi KOSAKA
  • Publication number: 20160047812
    Abstract: A method for detecting a colorectal cancer, including the steps of measuring an amount of exosomes expressing CD147 in a body fluid sample derived from a test individual with an anti-CD147 monoclonal antibody or a fragment thereof; and comparing a signal intensity of exosomes in the step with a signal intensity in a control individual, wherein a case where the signal intensity in the test individual is found to be stronger than the signal intensity in the control individual serves as an index of the presence of the colorectal cancer. According to the method of the present invention, whether or not a sample provider has a high possibility of developing a colorectal cancer can be judged. Therefore, the method is useful because the sample provider can take a means of inhibiting the progression of cancer.
    Type: Application
    Filed: March 19, 2014
    Publication date: February 18, 2016
    Applicants: THEORIA SCIENCE INC., SHIONOGI & CO., LTD.
    Inventors: Hideki OHTA, Hiroyuki OKAMOTO, Hikaru SONODA, Takahiro OCHIYA