Abstract: The present invention provides methods of making and using immunogenic oligosaccharide compositions comprising native O-linked and S-linked oligosaccharides coupled to a protein carrier, wherein the resultant conjugate elicits a protectively immunogenic response. These compositions may be useful in vaccines against pathogenic Candida species.
Type:
Grant
Filed:
April 25, 2003
Date of Patent:
May 25, 2010
Assignee:
Theracarb, Inc.
Inventors:
David R. Bundle, Mark Nitz, Jim E. Cutler
Abstract: Novel glycerol cyclic pyruvate derivates were prepared and demonstrated to inhibit the binding of an immobilized D-proline derivative to serum amyloid P component (SAP) have been prepared. As such, the compounds of the invention are useful for treating amyloidosis and diseases associated with amyloidosis, for example Alzheimer&supl;s disease and maturity onset diabetes mellitus.
Type:
Grant
Filed:
May 12, 2004
Date of Patent:
June 30, 2009
Assignee:
Theracarb Inc.
Inventors:
David Bundle, Pavel Kitov, Kenneth Kai-Sing Ng, Jason Gay Shuen Ho