Patents Assigned to TheRas, Inc.
  • Compositions and methods for inhibition of RAS
    Patent number: 12528818
    Abstract: Provided herein are compounds, or salts, esters, tautomers, prodrugs, zwitterionic forms, or stereoisomers thereof, as well as pharmaceutical compositions comprising the same. Also provided herein are methods of using the same in modulating (e.g., inhibiting) KRAS (e.g., KRAS having a G12C mutation) and treating diseases or disorders such as cancers in subjects in need thereof.
    Type: Grant
    Filed: May 1, 2025
    Date of Patent: January 20, 2026
    Assignees: Leidos Biomedical Research, Inc., Lawrence Livermore National Security, LLC, TheRas, Inc.
    Inventors: Bin Wang, Rui Xu, Eli Wallace, Zuhui Zhang, David Michael Turner, Anna Elzbieta Maciag, Dhirendra Kumar Simanshu, Albert Hay Wah Chan, Tao Liao, Christopher John Brassard, Yue Yang, Paola Bisignano, Felice Lightstone