Patents Assigned to Therasense, Inc.
  • Biological fuel cell and methods
    Patent number: 6531239
    Abstract: A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: March 11, 2003
    Assignee: TheraSense, Inc.
    Inventor: Adam Heller
  • Biosensor membranes composed of polymers containing heterocyclic nitrogens
    Publication number: 20030042137
    Abstract: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.
    Type: Application
    Filed: May 14, 2002
    Publication date: March 6, 2003
    Applicant: TheraSense, Inc.
    Inventors: Fei Mao, Hyun Cho
  • Subcutaneous glucose electrode
    Patent number: 6514718
    Abstract: A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: February 4, 2003
    Assignee: TheraSense, Inc.
    Inventors: Adam Heller, Michael V. Pishko
  • Biosensor
    Patent number: 6503381
    Abstract: A biosensor comprises a space part for sucking and housing a sample formed of two upper and lower plates, the two plates being stuck together by an adhesive layer, the space part for sucking and housing the sample being constituted so as to be partially opened in the peripheral part and partially closed by the adhesive layer, and has a working electrode having at least glucose oxidase immobilized thereon and a counter electrode on the same plane of the plate.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: January 7, 2003
    Assignee: TheraSense, Inc.
    Inventors: Masao Gotoh, Hiroki Mure, Hiroshi Shirakawa
  • Electrochemical analyte sensor
    Patent number: 6484046
    Abstract: An electrochemical analyte sensor having conductive traces on a substrate is used to determine a level of analyte in in vitro or in vivo analyte-containing fluids. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the fluid.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: November 19, 2002
    Assignee: TheraSense, Inc.
    Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke
  • Small Volume in Vitro Analyte Sensor and Methods
    Publication number: 20020157948
    Abstract: A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.
    Type: Application
    Filed: December 28, 2001
    Publication date: October 31, 2002
    Applicant: TheraSense, Inc.
    Inventors: Charles T. Liamos , Benjamin J. Feldman , Jeffery V. Funderburk , Rajesh Krishnan , Phillip John Plante , Joseph A. Vivolo , Robert Y. Jin , Michael S. Cloud
  • Small Volume in Vitro Analyte Sensor and Methods
    Publication number: 20020148739
    Abstract: A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector.
    Type: Application
    Filed: December 28, 2001
    Publication date: October 17, 2002
    Applicant: TheraSense, Inc.
    Inventors: Charles T. Liamos , Benjamin J. Feldman , Jeffery V. Funderburk , Rajesh Krishnan , Phillip John Plante , Joseph A. Vivolo , Robert Y. Jin , Michael S. Cloud
  • Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
    Patent number: 6461496
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: October 8, 2002
    Assignee: TheraSense, Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Small volume in vitro analyte sensor and methods
    Publication number: 20020084196
    Abstract: A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.
    Type: Application
    Filed: December 28, 2001
    Publication date: July 4, 2002
    Applicant: TheraSense, Inc.
    Inventors: Charles T. Liamos, Benjamin J. Feldman, Jeffery V. Funderburk, Rajesh Krishnan, Phillip John Plante, Joseph A. Vivolo, Robert Y. Jin, Michael S. Cloud
  • Multi-sensor array for electrochemical recognition of nucleotide sequences and methods
    Publication number: 20020081588
    Abstract: Sensor and method of its production and use in the electrochemical detection of nucleic acid sequences.
    Type: Application
    Filed: December 21, 2000
    Publication date: June 27, 2002
    Applicant: TheraSense, Inc.
    Inventors: Thierry De Lumley-woodyear, Daren J. Caruana, Adam Heller
  • Small volume in vitro analyte sensor and methods
    Publication number: 20020053523
    Abstract: A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the to analyte using the amount of charge and the amount of time.
    Type: Application
    Filed: December 28, 2001
    Publication date: May 9, 2002
    Applicant: TheraSense, Inc.
    Inventors: Charles T. Liamos, Benjamin J. Feldman, Jeffery V. Funderburk, Rajesh Krishnan, Phillip John Plante, Joseph A. Vivolo, Robert Y. Jin, Michael S. Cloud
  • Subcutaneous glucose electrode
    Publication number: 20020042090
    Abstract: A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
    Type: Application
    Filed: November 29, 2001
    Publication date: April 11, 2002
    Applicant: TheraSense, Inc.
    Inventors: Adam Heller, Michael V. Pishko
  • Lancing device and method of sample collection
    Publication number: 20020029058
    Abstract: A lancing device and method for self-collecting a sample of body fluid by penetrating a body tissue at a sampling site. The invention includes a housing geometry configured for ease of use at different sampling sites on the body, even by persons having reduced dexterity and/or poor vision. Depth of penetration is selectively controlled by adjusting the stroke range of a spring-driven lancet carrier. A pressure applicator is included for stimulating flow of the body fluid. A transparent portion permits observation of the sampling site.
    Type: Application
    Filed: August 14, 2001
    Publication date: March 7, 2002
    Applicant: TheraSense, Inc.
    Inventors: Richard W. Levaughn, Stephen J. Flynn, Gwenn E. Kennedy, Michael V. Lipoma
  • Biological fuel cell and methods
    Publication number: 20020025469
    Abstract: A fuel cell has an anode and a cathode with anode enzyme disposed on the anode and cathode enzyme is disposed on the cathode. The anode is configured and arranged to electrooxidize an anode reductant in the presence of the anode enzyme. Likewise, the cathode is configured and arranged to electroreduce a cathode oxidant in the presence of the cathode enzyme. In addition, anode redox hydrogel may be disposed on the anode to transduce a current between the anode and the anode enzyme and cathode redox hydrogel may be disposed on the cathode to transduce a current between the cathode and the cathode enzyme.
    Type: Application
    Filed: September 24, 2001
    Publication date: February 28, 2002
    Applicant: TheraSense, Inc.
    Inventor: Adam Heller
  • Combinatorial Electrochemical Synthesis
    Publication number: 20020008038
    Abstract: An array of selectively addressible microelectrodes for combinatorial synthesis of complex polymers or alloys.
    Type: Application
    Filed: December 22, 2000
    Publication date: January 24, 2002
    Applicant: TheraSense, Inc.
    Inventors: Adam Heller , Daren J. Caruana
  • Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
    Patent number: 6338790
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: January 15, 2002
    Assignee: TheraSense, Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffrey V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Electrodes with multilayer membranes and methods of using and making the electrodes
    Publication number: 20010054319
    Abstract: A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.
    Type: Application
    Filed: May 11, 2001
    Publication date: December 27, 2001
    Applicant: TheraSense, Inc.
    Inventors: Adam Heller, Ting Chen, Keith A. Friedman
  • Subcutaneous glucose electrode
    Patent number: 6329161
    Abstract: A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucoses is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
    Type: Grant
    Filed: September 22, 2000
    Date of Patent: December 11, 2001
    Assignee: TheraSense, Inc.
    Inventors: Adam Heller, Michael V. Pishko
  • Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
    Patent number: 6299757
    Abstract: A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
    Type: Grant
    Filed: October 6, 1999
    Date of Patent: October 9, 2001
    Assignee: TheraSense, Inc.
    Inventors: Benjamin J. Feldman, Adam Heller, Ephraim Heller, Fei Mao, Joseph A. Vivolo, Jeffery V. Funderburk, Fredric C. Colman, Rajesh Krishnan
  • Glucose strip
    Patent number: D450854
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: November 20, 2001
    Assignee: TheraSense, Inc.
    Inventors: Kelley J. Lipman, Joseph A. Vivolo, Travis Rowe