Abstract: The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.
Type:
Grant
Filed:
April 8, 2009
Date of Patent:
March 6, 2012
Assignee:
Theregen, Inc.
Inventors:
Gail K. Naughton, Jonathan Noel Mansbridge, Robert Emmett Pinney, Joan Zeltinger
Abstract: The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.
Type:
Application
Filed:
December 29, 2010
Publication date:
September 1, 2011
Applicant:
Theregen, Inc.
Inventors:
Gail K. Naughton, Jonathan Noel Mansbridge, Robert Emmett Pinney, Joan Zeltinger
Abstract: The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
Type:
Application
Filed:
September 2, 2010
Publication date:
February 10, 2011
Applicant:
Theregen, Inc.
Inventors:
Anthony Ratcliffe, Jonathan Noel Mansbridge, Lee K. Landeen, Emmett Pinney, Linette J. Edison
Abstract: The present invention relates to a method for promoting blood vessel formation in tissues and organs. In particular, the method relates to implantation or attachment of an engineered three-dimensional stromal tissue to promote endothelialization and angiogenesis in the heart and related tissues. The three-dimensional stromal tissue of the present invention may be used in a variety of applications including, but not limited to, promoting repair of and regeneration of damaged cardiac muscle, promoting vascularization and healing during cardiac surgery, promoting blood vessel formation at anastomosis sites, and promoting vascularization and repair of damaged skeletal muscle, smooth muscle or connective tissue.
Type:
Application
Filed:
April 8, 2009
Publication date:
October 29, 2009
Applicant:
Theregen, Inc.
Inventors:
Gail K. Naughton, Jonathan Noel Mansbridge, Robert Emmett Pinney, Joan Zeltinger
Abstract: The present disclosure provides compositions of three dimensional tissue that can be administered into tissues and organs using minimally invasive methods. The three dimensional tissues elaborate a repertoire of growth factors that facilitate repair or regeneration of damaged tissues and organs.
Type:
Application
Filed:
September 26, 2008
Publication date:
May 14, 2009
Applicant:
Theregen, Inc.
Inventors:
Anthony Ratcliffe, Jonathan Noel Mansbridge, Lee K. Landeen, Emmett Pinney, Linette J. Edison