Abstract: A wearable thermoregulation device, system, and method. A thermoelectric device is configured to controllably heat and cool a control surface. A power source is configured to provide power to operate the thermoelectric device. A wireless communications and control module is configured to wirelessly send and receive signals, and to control the thermoelectric device. A carrier structure carries the thermoelectric device, the power source, and the wireless communications and control module, and is configured to be removably carried on the body of a user such that the heated and cooled control surface is in direct contact with the user's skin.