Abstract: An embodiment of a system for measuring trace gas concentration is described that comprises a laser absorption spectrometer configured to detect an absorbance measure from a trace gas, as well as a temperature value and a pressure value that correspond to an environment in a gas cell; and a computer having executable code stored thereon configured to perform a method comprising: receiving the absorbance value, the temperature value, and the pressure value; defining a fitting range associated with the trace gas; applying a curve fitting model in the fitting range to the absorbance value using the temperature value and the pressure value as model parameters; and producing a concentration measure of the trace gas.
Abstract: A system including a display output device, a computer including instructions that when executed by the computer, cause the computer to generate a virtual environment, instantiate one or more virtual devices into the virtual environment, instantiate a user representation into the virtual environment, and display the virtual environment, the one or more virtual devices, and the user representation on the display output device, an input device to receive a movement input associated with movement by the user representation in the virtual environment, and the computer further configured with instructions to move or rotate the one or more virtual devices relative to a point of reference in the virtual environment in response to the movement input, while maintaining the user representation stationary.
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
Type:
Application
Filed:
November 5, 2021
Publication date:
October 6, 2022
Applicant:
Thermo Fisher Scientific Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
Type:
Grant
Filed:
February 5, 2020
Date of Patent:
December 14, 2021
Assignee:
THERMO FISHER SCIENTIFIC INC.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for LDHA.
Type:
Grant
Filed:
October 25, 2018
Date of Patent:
February 16, 2021
Assignee:
Thermo Fisher Scientific Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: An embodiment of a system is described that comprises an ionization chamber electrically coupled with a charge amplifier circuit by a reed switch. The reed switch of the embodiments described herein produces substantially no leakage current and electrically insulates the charge amplifier from the ionization chamber.
Type:
Grant
Filed:
May 30, 2018
Date of Patent:
October 20, 2020
Assignee:
Thermo Fisher Scientific Inc.
Inventors:
King L. Poon, Alexander Joseph Esin, Alexei Kulik, Huichun Xing
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for AAT.
Type:
Grant
Filed:
November 27, 2017
Date of Patent:
September 8, 2020
Assignee:
Thermo Fisher Scientific Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for HAO1.
Type:
Grant
Filed:
January 4, 2018
Date of Patent:
June 30, 2020
Assignee:
THERMO FISHER SCIENTIFIC INC.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. Be selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods compositions, and kits generated through rational design of siRNAs are disclosed, including those directed to the nucleotide sequences for COX-2.
Type:
Grant
Filed:
April 9, 2019
Date of Patent:
September 24, 2019
Assignee:
Thermo Fisher Scientific Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe
Abstract: A tamper seal detection system for detecting a sealing sticker on a packaging box includes a housing at least partially bounding an inspection zone, the inspection zone being configured to receive the packaging box. A first sensor is configured to detect the presence of the first sealing sticker located on the packaging box when the packaging box is received within the inspection zone. A push guide is movable relative to the inspection floor between a first position and a spaced apart second position and can be used to push the packaging box out of the inspection zone.
Type:
Grant
Filed:
October 17, 2017
Date of Patent:
May 14, 2019
Assignee:
Thermo Fisher Scientific, Inc.
Inventors:
Cody T. Kerschner, Christian S. Heaps, Justin J. Tomel, Shawn M. Regits
Abstract: Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed including those directed to nucleotide sequences for TTR.
Type:
Grant
Filed:
September 15, 2017
Date of Patent:
March 19, 2019
Assignee:
Thermo Fisher Scientific Inc.
Inventors:
Anastasia Khvorova, Angela Reynolds, Devin Leake, William Marshall, Steven Read, Stephen Scaringe