Patents Assigned to Thermo Fisher Scientific Oy
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Patent number: 9568403Abstract: The invention concerns a method for processing magnetic particles, which selectively interact with a substance present in a liquid medium. The particles are collected with a probe (2) comprising a hollow shield (4) and a probe magnet (3) moveable up and down. The lower end of the probe with the collected particles is placed on a release location (7) of a plate (6), below which release location there is a release magnet (8). The surface of the release location is dry or has a liquid film or a drop on it. In accordance with the invention, very high concentration ratios can be achieved.Type: GrantFiled: February 22, 2012Date of Patent: February 14, 2017Assignee: THERMO FISHER SCIENTIFIC OYInventor: Jukka Tuunanen
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Patent number: 9522395Abstract: A pipette is described which includes a piston for aspirating liquid into and dispensing out of a container in the pipette. The pipette is provided with at least one tracking element which is able to count the magnitude of some variable or variables relating to the amount of use of the pipette, at least one operating device for creating a limit magnitude for each variable, and for giving information when the limit value is exceeded. Thus, the user may, for instance, be warned when he may be exposed to high workload stress possibly causing injuries.Type: GrantFiled: February 13, 2013Date of Patent: December 20, 2016Assignee: Thermo Fisher Scientific OyInventors: Mikael Lind, Juha Telimaa
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Patent number: 9463456Abstract: An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, which user interface comprises a display, wherein the main menu of the user interface comprises a user defined shortcut to a specific pipetting application.Type: GrantFiled: May 13, 2014Date of Patent: October 11, 2016Assignee: Thermo Fisher Scientific OyInventor: Suvi Berghall
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Publication number: 20160046980Abstract: Transposon nucleic acids comprising a transposon end sequence and a calibration sequence for DNA sequencing in the transposon end sequence. In one embodiment, the transposon end sequence is a Mu transposon end. A method for the generation of DNA fragmentation library based on a transposition reaction in the presence of a transposon end with the calibration sequence providing facilitated downstream handling of the produced DNA fragments, e.g., in the generation of sequencing templates.Type: ApplicationFiled: August 26, 2015Publication date: February 18, 2016Applicant: Thermo Fisher Scientific OyInventors: Ian Kavanagh, Laura-Leena Kiiskinen, Heli Haakana
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Patent number: 9236236Abstract: A sample preparation and analysis system. The system includes a housing with a sample preparation station and a sample analysis station positioned within the housing. The sample analysis station is spaced away from the sample preparation station. A transport assembly is configured to move at least one sample within the housing and between the sample preparation station and the sample analysis station.Type: GrantFiled: July 17, 2014Date of Patent: January 12, 2016Assignee: Thermo Fisher Scientific OyInventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Jukka Saukkonen, John Edward Brann, III, Terry N. Olney
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Patent number: 9223930Abstract: Methods and systems for identifying a quantitation cycle (Cq) for a PCR reaction that includes fitting a line having a plurality of line segments to data points associated with a PCR amplification reaction. The data points include a cycle value associated with a PCR cycle and a product value associated with a PCR product. A baseline is identified and reaction segment associated with an exponential region of the PCR reaction is also identified. The reaction segment includes a subset of the plurality of line segments having a slope not less than a steepness criterion. A reaction line is fit to the data points associated with the reaction segment. The Cq is identified by calculating the cycle value for a data point defining the intersection of the baseline and reaction line.Type: GrantFiled: July 27, 2012Date of Patent: December 29, 2015Assignee: Thermo Fisher Scientific OyInventors: Jorma Mustola, Antti Koski
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Patent number: 9145623Abstract: Transposon nucleic acids comprising a transposon end sequence and a calibration sequence for DNA sequencing in the transposon end sequence. In one embodiment, the transposon end sequence is a Mu transposon end. A method for the generation of DNA fragmentation library based on a transposition reaction in the presence of a transposon end with the calibration sequence providing facilitated downstream handling of the produced DNA fragments, e.g., in the generation of sequencing templates.Type: GrantFiled: July 19, 2012Date of Patent: September 29, 2015Assignee: THERMO FISHER SCIENTIFIC OYInventors: Ian Kavanagh, Laura-Leena Kiiskinen, Heli Haakana
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Patent number: 9000360Abstract: A sample preparation and analysis system (10). The system (10) includes a housing (16) with a sample preparation station (12) and a sample analysis station (14) positioned within the housing (16). The sample analysis station (14) is spaced away from the sample preparation station (12). A transport assembly (50) is configured to move at least one sample within the housing (16) and between the sample preparation station (12) and the sample analysis station (14).Type: GrantFiled: October 28, 2011Date of Patent: April 7, 2015Assignee: Thermo Fisher Scientific OyInventors: Robert DeWitte, Juhani Siidorov, Vesa Nuotio, Jukka Saukkonen, John Edward Brann, III, Terry N. Olney
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Patent number: 8962306Abstract: The invention relates to a device for thermal cycling of biological samples, a heat sink used in such a device and a method. The heat sink comprises a base plate designed to fit in a good thermal contact against a generally planar thermoelectric element included in the device, and a plurality of heat transfer elements projecting away from the base plate. According to the invention the heat transfer elements of the heat sink and arranged in a non-parallel configuration with respect to each other for keeping the temperature of the base plate of the heat sink spatially uniform during thermal cycling.Type: GrantFiled: September 8, 2006Date of Patent: February 24, 2015Assignee: Thermo Fisher Scientific OyInventors: David Cohen, Sakari Viitamaki
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Publication number: 20140334993Abstract: An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, which user interface comprises a display, wherein the main menu of the user interface comprises a user defined shortcut to a specific pipetting application.Type: ApplicationFiled: May 13, 2014Publication date: November 13, 2014Applicant: Thermo Fisher Scientific OyInventor: Suvi Berghall
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Publication number: 20140331794Abstract: An electronic pipette comprising a piston actuated in a cylinder by a motor, a control system for carrying out pipette operations, and a user interface for operating the pipette, wherein the user interface comprises features for defining at least one dilution variable for pipetting operations based on input pipetting operation variables of which one is dilution ratio.Type: ApplicationFiled: May 13, 2014Publication date: November 13, 2014Applicant: Thermo Fisher Scientific OyInventors: Suvi Berghall, Juha Telimaa, Mikael Lind
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Publication number: 20140273254Abstract: Methods and systems are described for quantifying the methylation status of nucleic acids in a sample utilizing standardized curves derived from methylation-sensitive HRM data. The standardized curves are generated from HRM curves from a plurality of samples, each sample having a known but different methylation status. In one embodiment, the first negative derivative of each HRM curve from the known samples is plotted and a first value corresponding with a first melt peak and a second value corresponding with a second melt peak from the negative derivative plots are identified. The slope of a line connecting the first and second values for each sample is calculated and used to identify a slope data point that is plotted to generate the standardized curve. In another embodiment, a threshold line that intersects the plurality of HRM curves is generated and the standardized curve is generated from the intersection data points.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Thermo Fisher Scientific OyInventor: Jaakko Kurkela
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Publication number: 20140224382Abstract: A reagent bottle includes an outer cap and an inner closing cap. The inner closing cap has a recess for gripping the cap. In addition, a system for handling closures is provided wherein a method removes a closing cap from a reagent bottle and a related gripper.Type: ApplicationFiled: April 28, 2014Publication date: August 14, 2014Applicant: Thermo Fisher Scientific OyInventors: Vesa NUOTIO, Juha NUMMIPURO, Olli MYYRYLÄINEN
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Publication number: 20140099658Abstract: The invention concerns a method for processing magnetic particles, which selectively interact with a substance present in a liquid medium. The particles are collected with a probe (2) comprising a hollow shield (4) and a probe magnet (3) moveable up and down. The lower end of the probe with the collected particles is placed on a release location (7) of a plate (6), below which release location there is a release magnet (8). The surface of the release location is dry or has a liquid film or a drop on it. In accordance with the invention, very high concentration ratios can be achieved.Type: ApplicationFiled: February 22, 2012Publication date: April 10, 2014Applicant: THERMO FISHER SCIENTIFIC OYInventor: Jukka Tuunanen
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Patent number: 8689982Abstract: The invention relates to a device (2) for separating magnetic particles comprising several substantially aligned magnets (3). Some of the magnets (3) are inversely oriented. This array reduces any magnetic interference with the collection area of an adjacent magnet.Type: GrantFiled: November 9, 2004Date of Patent: April 8, 2014Assignee: Thermo Fisher Scientific OyInventors: Timo Karmeniemi, Jukka Tuunanen
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Publication number: 20140056781Abstract: The invention relates to liquid dispensing and concerns a pipette comprising at least one aspiration channel with a piston. At the lower end of the aspiration channel there is an extension channel (3) and at its end a pipette tip mounting piece (4) onto which a pipette tip (5) is attached. On the pipette tip mounting piece there is a surrounding groove (17) and in the groove a sealing ring (18). The width of the groove in the axial direction is at least 1.1 times the thickness of the sealing ring in the axial direction. When the mounting piece is pushed into the pipette tip, the inner wall of the tip can move the sealing ring upwards in the groove. The construction can provide a reliable sealing despite of inherent dimension differences between different tips and mounting pieces.Type: ApplicationFiled: August 20, 2013Publication date: February 27, 2014Applicant: Thermo Fisher Scientific OyInventors: Ari JAASKELAINEN, Mikael LIND, Juha TELIMAA, Aaro TUOMINEN
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Patent number: 8641968Abstract: A chemical analyzer, a method for sample-based analysis, a device for handling cuvette assemblies including a rotatable incubator with at least one curved opening for receiving a new cuvette assembly, an analyzer arranged around the incubator for analyzing contents of the new cuvette assembly, and a loading device adapted to carry the new cuvette assembly while initially being aligned in a straight manner before being loaded. The loading device includes a feed funnel having a first end for receiving the new cuvette assembly initially aligned in the straight manner into the feed funnel, and a second end for feeding the new cuvette assembly into the at least one curved opening, the second end having a curvature which corresponds to the curvature of the curved opening, the second end for bending the initially straight new cuvette assembly and fitting the new cuvette assembly into the at least one curved opening.Type: GrantFiled: May 27, 2009Date of Patent: February 4, 2014Assignee: Thermo Fisher Scientific OyInventors: Vesa Nuotio, Ville Saarainen, Juha Savonsalmi
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Patent number: D753424Type: GrantFiled: February 19, 2015Date of Patent: April 12, 2016Assignee: Thermo Fisher Scientific OyInventor: Lauri Peltosaari
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Patent number: D769653Type: GrantFiled: February 24, 2016Date of Patent: October 25, 2016Assignee: Thermo Fisher Scientific OyInventor: Lauri Peltosaari
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Patent number: D777940Type: GrantFiled: February 19, 2015Date of Patent: January 31, 2017Assignee: Thermo Fisher Scientific OyInventors: Lauri Peltosaari, Joni Rannisto