Abstract: A dynamic temperature regulating device is for use in association with a temperature-controlled container. The dynamic temperature regulating device includes at least one heat source, at least one heat sink, a heat transfer medium and a control system. At least one of the heat source and the heat sink is a PCM (phase change material). The heat transfer medium is in thermal communication with and operably connected to the at least one heat source and the at least one heat sink. The control system is for controlling the selective thermal communication with the at least one heat source and with the at least one heat sink to regulate the temperature of the temperature-controlled container. A detachable PCM contained volumes includes a sealed housing, a phase change material and a heat transfer medium and functions as a PCM thermal energy storage volume.