Abstract: Disclosed herein are systems for imaging and ablating a sample. An imaging/ablating device (110) includes an optical assembly (112), a sample stage (114), and a receiver (116). The optical assembly (112) is disposed in an inverted position below the sample stage (114) and the receiver (116) is positioned above the sample stage (112). The optical assembly enables imaging of a sample disposed on the sample stage (114). The optical assembly (112) also enables ablation of a region of interest within the sample. The laser light propagated from the optical assembly during ablation propagates substantially in the same direction as the direction of travel of the ablation plume (20) toward the receiver (116).

Abstract: A method comprises: aspirating a sample through a needle capillary into a chamber having first and second windows, the capillary and chamber both affixed to a moveable robotic arm; causing a light beam generated by a light source that is affixed to the robotic arm to pass through the sample between the windows; detecting, using a photodetector that is affixed to the robotic arm, a quantity of the light that passes through the sample and the windows; determining an optical absorbance of the sample and a concentration of an analyte in the sample from the detected quantity of light; determining a quantity of the sample to dispense into an analytical apparatus based on the determined concentration; moving the robotic arm so as to cause the needle capillary to mate with an inlet port of an analytical apparatus; and dispensing the determined quantity of the sample into the analytical apparatus.

Abstract: A method of determining one or more interference parameters for a particular peak of an isotopic distribution corresponding to a precursor molecule in MS scan data is provided. The MS scan data comprises a plurality of peaks. Each peak has a mass-to-charge ratio and a relative abundance. The isotopic distribution comprises a subset of the plurality of peaks. The one or more interference parameters comprises a peak purity, pi, for the particular peak. The method comprises determining that there are no interfering peaks relevant to the isotopic distribution and determining that the peak purity, pi, for the particular peak should be a maximum purity value.

Abstract: A data processing device comprises a processor unit adapted to process a plurality of initial data vectors provided by a chromatograph and/or a mass spectrometer, the processing being carried out in one, two or more processing steps producing items of processed data, and a storage unit adapted to save and retrieve initial data vectors and/or items of processed data, in particular processed data vectors or identified compounds, and/or items of additional data, in particular properties of the sample introduced in the mass spectrometer. Each item of processed data and/or additional data is connected to at least one initial data vector, and wherein the processor unit is adapted to group, select and/or modify initial data vectors and/or items of processed data according to one or more items of additional data.

Abstract: A switching mode power supply includes a microcontroller, an interface circuit connected to the controller, and a boost circuit connected to the controller. A feedback circuit is connected to the controller, and an SiPM is connected to the boost circuit and the feedback circuit.

Abstract: Trapping ions in an ion trapping assembly is described. In one aspect, this is implemented by introducing ions into the ion trapping assembly, applying a first RF trapping amplitude to the ion trapping assembly so as to trap introduced ions which have m/z ratios within a first range of m/z ratios, and cooling the trapped ions. In some aspects, also performed is reducing the RF trapping amplitude from the first RF trapping amplitude to a second, lower, RF trapping amplitude so as to reduce the low mass cut-off of the ion trapping assembly and trapping, at the second, lower RF trapping amplitude, introduced ions having m/z ratios within a second range of m/z ratios. A lower mass limit of the second range of m/z ratios is below the low mass cut-off of the ion trapping assembly when the first RF trapping amplitude is applied.

Abstract: A method for determining a compensation factor parameter, c, for controlling an amount of ions ionised that are injected from an ion storage unit into mass analyser, where c is an adjustment factor that is applied to optimized injection times that are based on an optimized visible charge of a reference sample, the method comprising: detecting at least one mass spectrum for at least one amount of injected ions; determining from the at least one detected mass spectrum, a slope, s(sample), of a linear correlation of a relative m/z shift with visible total charge Qv of detected mass spectra; determining the compensation factor c as c=s(reference)/s(sample) where s(reference) is the slope of a linear correlation between reference-sample relative m/z shift values and reference-sample visible charge values determined from a plurality of mass spectra detected from a plurality of respective pre-selected amounts of a clean reference sample.

Abstract: A mass spectrometer includes a controller operable to: transfer first ions of a first charge into an ion trap; apply an RF pseudopotential that radially confines the first ions in an elongate ion channel of the trap; generate a first potential well that confines the first ions within a first volume; after a specified pre-cooling time, transfer second ions of a second, opposite charge into the trap; apply one or more additional DC potentials that generate a second potential well that confines the second ions within a second volume, the first potential well being within the second potential well; cause, after cooling the second ions, the first ions and the second ions to interact and generate product ions; and generate at least one third potential well that confines the product ions, that is adjacent to the second potential well and that has a same polarity as the first potential well.

Abstract: A mass spectrometer collision cell system, comprising: a gas containment vessel comprising an internal chamber having ion inlet and ion outlet ends and a cross-sectional area, Achamber; a gas inlet aperture; first and second gas outlet apertures that are disposed at or proximal to the ion inlet and outlet ends, respectively, and that have respective outlet aperture cross-sectional areas, Aaperture1 and Aaperture2, and an average outlet aperture cross-sectional area, Aapertureave; a longitudinal axis of the chamber extending from the ion inlet end to the ion outlet end and having a length, Lchamber; and a set of multipole rod electrodes, at least a portion of each multipole rod electrode being within the chamber, wherein the values of Achamber, Lchamber and Aapertureave are such that the combined gas conductance of the chamber and the gas outlet apertures is not greater than 95 percent of the gas conductance of the gas outlet apertures alone.

Abstract: A method for determining a quantity of an analyte in a liquid sample, comprises: adding a known quantity of an internal standard comprising an isotopically labeled version of the analyte to the sample; (b) providing a continuous stream of the sample having the internal standard to an inlet of a Liquid Chromatography Mass Spectrometry (LCMS) system; and repeatedly performing the steps of: performing a data-independent analysis of the precursor ion species using a mass analyzer, whereby mass spectra of a plurality of fragment-ion species are acquired; calculating one or more degree-of-matching scores that relate to either a number of ions of the internal standard that overlap between results of the data-independent analysis and tabulated mass spectral data of the internal standard; and performing quantitative tandem mass spectrometric analyses of the internal standard and the analyte if each of the degree-of-matching scores meets a respective degree-of-matching condition.

Abstract: Techniques for determining a microbial classification based on a mass spectrum are disclosed. A mass spectrometer generates a mass spectrum for a biological sample. A binning function is applied to the mass spectrum to generate a binned mass spectrum. As an example, a binned mass spectrum is associated with a set of bins having mass errors of the same value. A classification algorithm is applied to the binned mass spectrum to determine a microbial classification.

Abstract: A freezer and method of operating a freezer are provided with an adaptive defrost cycle. The freezer includes a controller that operates the freezer to: provide cooling to a cabinet via an evaporator during periodic operational cycles, monitor a time elapsed since a most recent defrost cycle, determine whether the time elapsed is greater than a current defrost interval, and perform a defrost cycle if so. The controller varies the current defrost interval between a first, larger time value and a second, smaller time value based on a plurality of trigger signals in response to various operating characteristics of the freezer monitored by sensors. After each defrost cycle is completed, the current defrost interval is reset to the first, larger time value.

Abstract: A method for removing deposits in a mass spectrometer ion source housing includes delivering a liquid from a liquid source to a surface within the ion source housing. The surface including an ultrasonic transducer embedded within the surface. The method further includes activating the ultrasonic transducer to ultrasonically remove the deposit.

Abstract: A transport climate control system is disclosed. The system includes a compressor, a motor-generator-rectifier machine, a belt drive connected to the motor-generator-rectifier machine and the compressor, at least one condenser fan, at least one evaporator fan, and a DC to DC converter. The motor-generator-rectifier machine connects to the at least one condenser fan, the at least one evaporator fan, and the DC to DC converter. The motor-generator-rectifier machine includes a motor, a low voltage generator connected to the motor, and a rectifier connected to the low voltage generator. The motor-generator-rectifier machine can provide a first low voltage DC power to the at least one condenser fan, the at least one evaporator fan, and the DC to DC converter. The DC to DC converter can convert the first low voltage DC power to a second low voltage DC power that is different from the first low voltage DC power.

Abstract: The present disclosure relates to a method for operating a temperature control system for a temperature controlled goods vehicle, wherein the temperature control system comprises: a solar panel and a temperature control unit comprising: one or more temperature control components; a battery coupled to the solar cell (200) for receiving a first charging current i1 from the solar cell; an engine operative to supply a second charging current i2 to the battery; and a controller.

Abstract: A receptacle holder having a base body, a first perimeter wall which at least partially protrudes from the base body, and a plurality of resilient elements, which are distributed about a first axis of the receptacle holder and are detachably connected with the first perimeter wall, and wherein each resilient element comprises a first end portion and a second end portion, and wherein each second end portion rests hooked over an edge of a portion of the first perimeter wall, and wherein the receptacle holder is configured to allow sliding of each second end portion in a direction perpendicular to the first axis.

Abstract: A radiation detector includes a printed circuit board and a detector assembly operably connected to the printed circuit board. The detector assembly includes a silicon photomultiplier and an organic scintillator coating applied to a surface of the silicon photomultiplier. A reflective foil covers the organic scintillator coating. A light sealing cover is secured to the printed circuit board such that the silicon photomultiplier and the organic scintillator are encapsulated within the light sealing cover.

Abstract: A signal processing assembly for a detector includes a signal amplifier, a control unit, and an offset control module. The signal amplifier is configured to receive an input signal from the detector assembly and to provide an output signal. The control unit is configured to compare a first data point from the output signal with a signal range, and to generate an input bias control signal based upon the comparison. The offset control module is coupled with the control unit and configured to receive the input bias control signal. The offset control module includes a power supply operatively coupled with an input of the signal amplifier, and the offset control module is configured to generate and apply an adaptive input offset signal at the input of the signal amplifier based upon the input bias control signal.