Abstract: A computer-implemented method for supporting disease diagnosis is provided that includes: a) generating and storing a list of user-selected broad symptoms; b) using the list of user-selected broad symptoms to generate and store a list of related disease presentations or diseases; c) using at least one machine knowledge system to identify a collection of disease-specific symptoms that are related to the disease presentations or diseases of the list of related disease presentations or diseases; d) presenting to the user disease-specific symptoms belonging to the collection of disease-specific symptoms for associated user input; e) using the user input associated with the disease-specific symptoms to determine matching scores for diseases presentations or diseases of the list of related disease presentations or diseases; and f) using the matching scores for the diseases presentations or diseases to present to the user rankings or groupings for diseases corresponding to the of the list of related disease presenta