Abstract: Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

Abstract: Systems and methods for delivering a gas, such as nitric oxide, are provided. In some embodiments, systems and methods are provided for delivering a gas, such as nitric oxide, in the form of nanobubbles and/or a dissolved gas using a liquid medium.

Abstract: Architectures for production of nitric oxide (NO) include systems and methods for generating NO having one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing NO using a flow of the reactant gas through one or more plasma chambers; a controller configured to regulate the amount of nitric oxide in the product gas using one or more parameters as an input to the controller, one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which product gas flows; and a flow divider configured to divide a product gas flow from the plasma chamber into a first product gas flow to provide a variable flow to a patient inspiratory flow and a second product gas flow.

Abstract: The present disclosure describes systems and methods for controlling the electrical generation of nitric oxide. In some aspects, a system for generating nitric oxide comprises a plasma chamber housing two or more electrodes in communication with a resonant high voltage circuit configured to send a signal to the plasma chamber for generating nitric oxide in a product gas from a flow of a reactant gas, and a controller configured to generate a pulse width modulation signal having multiple harmonic frequencies to excite the resonant high voltage circuit. The controller is configured to adjust the duty cycle of the pulse width modulation signal, the controller selecting the duty cycle based on a target voltage before plasma formation and a target current after plasma formation in the plasma chamber.

Abstract: Systems and methods are provided for generating a nitric oxide (NO) gas. A plasma generating device is configured to produce a plasma to ionize a flow of a reactant gas into a product gas that comprises NO, NO2, oxygen, and nitrogen gases. A controller is configured to regulate an amount of NO in the product gas using parameters as input to the controller. A gas separation device comprising a housing including product gas inlets and sweep fluid inlets to receive a flow of the product gas and a flow of the sweep fluid such that the flows of product gas and sweep fluid are opposed flows. A membrane is positioned inside the housing and permits flow of a subset of gases of the product gas therethrough so the product gas exiting the housing includes NO.

Abstract: Systems and methods for delivering a gas, such as nitric oxide, are provided. In some embodiments, systems and methods are provided for delivering a gas, such as nitric oxide, in the form of nanobubbles and/or a dissolved gas using a liquid medium.

Abstract: Systems and methods for generating nitric oxide are disclosed. A nitric oxide (NO) generation system includes at least one pair of electrodes configured to generate a product gas containing NO from a flow of a reactant gas; and a controller configured to regulate the amount of nitric oxide in the product gas produced by the at least one pair of electrodes by utilizing duty cycle values of plasma pulses selected from a plurality of discrete duty cycles to produce a target rate of NO production based on an average of discrete production rates associated with each of the plurality of discrete duty cycles.

Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

Abstract: Systems and methods for nitric oxide (NO) delivery are provided. A NO delivery system can include one or more pairs of electrodes configured to ionize a reactant gas into an NO-containing product gas, a delivery line to deliver at least a portion of the product gas into an inspiratory flow of gas, and a controller. The controller is configured to control an amount of NO in the product gas generated by the one or more pairs of electrodes using one or more parameters as input to the at least one controller. One of the parameters is a dilution value derived as a function of an inspiratory flow rate and a target inspiratory gas NO concentration level. The dilution value is used by the controller to set a flow rate of the product gas injected into the inspiratory flow and to determine a target concentration of NO in the product gas.

Abstract: System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.

Abstract: Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Abstract: Systems, devices, and methods are provided for generating NO and delivering NO in controlled amounts. A system for generating nitric oxide (NO) is provided, and in some embodiments can include a converter configured to convert a source material to a NO-containing gas, at least one controller configured to independently control a conversion of the source material to the NO-containing gas and a delivery of the NO-containing gas to an inspiratory pathway, and one or more sensors configured to communicate, to the at least one controller, information related to the conversion of the source material to the NO-containing gas.

Abstract: Systems, methods and devices for nitric oxide generation are provided for use with various ventilation and/or medical devices and having a humidity control system associated therewith. In some embodiments, a system for generating nitric oxide comprises at least one pair of electrodes configured to generate a product gas containing nitric oxide from a reactant gas, a scrubber configured to remove nitric dioxide NO2 from the product gas, and a humidity control device configured to alter a water content of at least one of the reactant gas and the product gas to control humidity within the system.

Abstract: Architectures for production of nitric oxide (NO) include systems and methods for generating NO having one or more plasma chambers configured to ionize a reactant gas to generate a plasma for producing a product gas containing NO using a flow of the reactant gas through one or more plasma chambers; a controller configured to regulate the amount of nitric oxide in the product gas using one or more parameters as an input to the controller, one or more parameters including information from a plurality of sensors configured to collect information relating to at least one of the reactant gas, the product gas, and a medical gas into which product gas flows; and a flow divider configured to divide a product gas flow from the plasma chamber into a first product gas flow to provide a variable flow to a patient inspiratory flow and a second product gas flow.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

Abstract: System and methods for providing nitric oxide can include at least one pair of electrodes configured to generate a product gas containing nitric oxide from a flow of a reactant gas, and at least one controller configured to regulate an amount of nitric oxide in the product gas generated by the at least one pair of electrodes using one or more parameters as an input to the controller. One or more sensors are configured to collect information relating to at least one of patient information, the reactant gas, the product gas, and an inspiratory gas into which at least a portion of the product gas flows, the sensors configured to communicate the information to the controller to be used as the one or more parameters. The patient information includes information relating to a methemoglobin (MetHg) measurement collected from a MetHg sensor.

Abstract: Systems and methods for delivering a gas, such as nitric oxide, are provided. In some embodiments, systems and methods are provided for delivering a gas, such as nitric oxide, in the form of nanobubbles and/or a dissolved gas using a liquid medium.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.