Patents Assigned to Thomas C. Elder, Inc.
  • 5'-Aminoalkyl-4',4-dialkylpsoralens
    Patent number: 4298614
    Abstract: The invention relates to 5'-aminoalkyl-4',4-dialkylpsoralens having enhanced photosensitizing activity, especially oral activity, including early onset, increased maximum, and rapid decline, as well as low toxicity, when compared with psoralens of different structure.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: November 3, 1981
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • 8-Aminoalkyl-4-alkylisopsoralens
    Patent number: 4294847
    Abstract: The invention relates to 8-aminoalkyl-4-alkylisopsoralens, especially 8-aminomethyl-4-methylisopsoralen, having enhanced photosensitizing activity, especially oral and topical activity, pharmaceutical compositions thereof, and method of effecting photosensitization therewith.
    Type: Grant
    Filed: July 29, 1980
    Date of Patent: October 13, 1981
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • 5-Aminoalkyl-4,4,8-trialkylpsoralens
    Patent number: 4294822
    Abstract: The invention relates to 5'-aminoalkyl-4',4,8-trialkylpsoralens having enhanced photosensitizing activity, especially oral and topical activity, as well as low toxicity, when compared with psoralens of different structure.
    Type: Grant
    Filed: July 29, 1980
    Date of Patent: October 13, 1981
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • Photosensitizing benzofuranacrylics
    Patent number: 4279922
    Abstract: The invention relates to 5-benzofuranacrylic acid compounds, preferably loweralkyl-substituted in the benzofuran ring system, which have photosensitizing activity, especially oral and topical activity, as well as low toxicity.
    Type: Grant
    Filed: July 29, 1980
    Date of Patent: July 21, 1981
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • 4'-Substituted-4,5',8-trialkylpsoralens
    Patent number: 4269852
    Abstract: The invention relates to 4,5',8-trialkylpsoralens, having a substituent on the 4' carbon atom which is selected from hydroxyalkoxyalkyl and hydroxyalkylaminoalkyl, which are characterized by enhanced photosensitizing activity, especially oral activity, including comparable maxima, early onset, and especially rapid decline, as well as low toxicity, when contrasted with psoralens of different structure.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: May 26, 1981
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • 8-Aminoalkyl-4-alkylpsoralens
    Patent number: 4269851
    Abstract: The invention relates to 8-aminoalkyl-4-alkylpsoralens having enhanced photosensitizing activity, especially oral activity, including early onset, increased maximum, and rapid decline, as well as low toxicity, when compared with psoralens of different structure.
    Type: Grant
    Filed: September 10, 1979
    Date of Patent: May 26, 1981
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • 6 Or 8 Haloallyl substituted 7-hydroxycoumarins
    Patent number: 4235781
    Abstract: .alpha.-Loweralkylfurocoumarins are produced by forming a .beta.-haloalk-2-enyl, e.g., .beta.-haloallyl, ether of a hydroxycoumarin having an active hydrogen in the position ortho to the hydroxy group, and heating the formed ether, preferably in dimethylaniline or like basic amine solvent. An abnormal Claisen rearrangement produces a novel o-hydroxy-(.beta.-haloalk-2-enyl) coumarin intermediate which can be dehydrohalogenated directly without isolation to the desired .alpha.-loweralkylfurocoumarin, e.g., .alpha.-methylfurocoumarin.
    Type: Grant
    Filed: September 20, 1979
    Date of Patent: November 25, 1980
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • Process for making .alpha.-loweralkylfurocoumarins
    Patent number: 4216154
    Abstract: .alpha.-Loweralkylfurocoumarins are produced by forming a .beta.-haloalk-2-enyl, e.g., .beta.-haloallyl, ether of a hydroxycoumarin having an active hydrogen in the position ortho to the hydroxy group, and heating the formed ether, preferably in dimethylaniline or like basic amine solvent. An abnormal Claisen rearrangement produces a novel o-hydroxy-(.beta.-haloalk-2-enyl) coumarin intermediate which can be dehydrohalogenated directly without isolation to the desired .alpha.-loweralkylfurocoumarin, e.g., .alpha.-methylfurocoumarin.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: August 5, 1980
    Assignee: Thomas C. Elder, Inc.
    Inventor: Kurt D. Kaufman
  • Process for making .omega.-chloro-2,3,4-trihydroxyacetophenone
    Patent number: 4129576
    Abstract: 8-Methoxypsoralen is prepared in six steps from pyrogallol including condensation of pyrogallol with a two-fold excess of chloroacetic acid with boron trifluoride hydrogenation of 6,7-dihydroxy-2,3-dihydrobenzofuran and dehydrogenation of 2,3-dihydroxanthotoxin. Improvements in these three steps lead to a marked overall increase in yield.
    Type: Grant
    Filed: June 24, 1976
    Date of Patent: December 12, 1978
    Assignee: Thomas C. Elder, Inc.
    Inventors: Louis J. Glunz, Donald E. Dickson
  • 8-Methoxypsoralen
    Patent number: 4129575
    Abstract: 8-Methoxypsoralen is prepared in six steps from pyrogallol including hydrogenation of 6,7-dihydroxy-2,3-dihydrobenzofuran and dehydrogenation of 2,3-dihydroxanthotoxin. Improvements in these two steps lead to a marked overall increase in yield.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: December 12, 1978
    Assignee: Thomas C. Elder, Inc.
    Inventors: Louis J. Glunz, Donald E. Dickson
  • 8-Methoxypsoralen
    Patent number: RE30376
    Abstract: 8-Methoxypsoralen is prepared in six steps from pyrogallol including hydrogenation of .[.6,7-dihydroxy-2,3-dihydrobenzofuran.]. .Iadd.6,7-dihydroxycoumaranone .Iaddend.and dehydrogenation of .[.2,3.]. .Iadd.4',5'.Iaddend.-dihydroxanthotoxin. Improvements in these two steps lead to a marked overall increase in yield.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: August 19, 1980
    Assignee: Thomas C. Elder, Inc.
    Inventors: Louis J. Glunz, Donald E. Dickson
  • Process for making .omega.-chloro-2,3,4-trihydroxyacetophenone
    Patent number: RE30377
    Abstract: 8-Methoxypsoralen is prepared in six steps from pyrogallol including condensation of pyrogallol with a two-fold excess of chloroacetic acid with boron trifluoride hydrogenation of .[.6,7-dihydroxy-2,3-dihydrobenzofuran.]. .Iadd.6,7-dihydroxycoumaranone .Iaddend.and dehydrogenation of .[.2,3.]. .Iadd.4',5'.Iaddend.-dihydroxanthotoxin. Improvements in these three steps lead to a marked overall increase in yield.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: August 19, 1980
    Assignee: Thomas C. Elder, Inc.
    Inventors: Louis J. Glunz, Donald E. Dickson