Patents Assigned to Thomas E. Meigs
  • Farnesyl compounds as farnesyl protein transferase inhibitors to treat ras induced tumor growth
    Patent number: 5567729
    Abstract: Farnesyl derivatives, particularly farnesyl acetate, are used to reduce the level of protein farnesylation in a mammalian host. The activity of proteins which require farnesylation for function is thereby reduced. The compounds may be administered to patients to reduce the overall level of ras protein activity, either alone or in conjunction with other drugs which act as competitive inhibitors of farnesyl protein transferase.
    Type: Grant
    Filed: October 28, 1993
    Date of Patent: October 22, 1996
    Assignees: David L. Bradfute, Thomas E. Meigs, Robert D. Simoni
    Inventors: David L. Bradfute, Robert D. Simoni, Thomas E. Meigs